論文

査読有り
1996年6月

The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats

NEPHRON
  • J Wada
  • ,
  • K Shikata
  • ,
  • H Makino
  • ,
  • S Morioka
  • ,
  • K Hirata
  • ,
  • K Ota
  • ,
  • T Tamatani
  • ,
  • M Miyasaka
  • ,
  • T Horiuchi
  • ,
  • S Noji
  • ,
  • K Nishikawa
  • ,
  • F Myokai
  • ,
  • S Taniguchi
  • ,
  • YS Kanwar
  • ,
  • Z Ota

73
2
開始ページ
264
終了ページ
272
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
KARGER

Intercellular adhesion molecule-1 (ICAM-1, CD54), an adhesion molecule of the immunoglobulin superfamily, is an endothelial cell surface ligand for such leukocyte integrins as lymphocyte-function-associated molecule 1 (LFA-1, CD11a/CD18), Mac-1 (CD11b/CD18) and CD43. These molecules mediate adhesive interactions between leukocytes and endothelial cells and are critically involved in infiltration of leukocytes into inflammatory lesions, We examined time expression of ICAM-1 in renal tissues of Masugi nephritis rats and directly examined time role of ICAM-1 by administration of neutralizing monoclonal antibodies (MAbs) to rat ICAM-1, LFA-1 alpha-subunit (LFA-1 alpha), beta-subunit (LFA-1 beta) and Mac-1 alpha-subunit (Mac-1 alpha). Within 3 h after injection of nephrotoxic serum, increased expression of ICAM-1 was detected in the glomeruli by in situ hybridization and an immunofluorescence study, Proteinuria was significantly suppressed by the MAbs against ICAM-1, Mac-1 alpha and LFA-1 beta. Neutrophil in filtration into the glomeruli was significantly prevented by injection of the MAbs against ICAM-1, LFA-1 alpha and LFA-1 beta. These results indicate both ICAM-1/LFA-1 and ICAM-1/Mac-1 pathways are involved in neutrophil infiltration into the glomeruli. On the other hand, monocytic infiltration was prevented by the MAbs against ICAM-1, LFA-1 alpha and LFA-1 beta but not hy anti-Mac-1 alpha MAb. Due to these results, ICAM-1 is considered to be a critical molecule involved in the pathogenesis of the leukocyte infiltration into the glomeruli in the heterologous phase of Masugi nephritis. Anti-ICAM-1 antibody may be beneficial in the treatment of leukocyte-mediated glomerular diseases.

Web of Science ® 被引用回数 : 18

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1996UN78500023&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • ISSN : 0028-2766
  • ORCIDのPut Code : 17913180
  • Web of Science ID : WOS:A1996UN78500023

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