論文

査読有り
1994年4月

IMMUNOREACTIVITY OF THE JK-132 MONOCLONAL-ANTIBODY DIRECTED AGAINST BASEMENT-MEMBRANE COLLAGEN IN NORMAL AND DIABETIC GLOMERULI

VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
  • H MAKINO
  • ,
  • K SHIKATA
  • ,
  • T HAYASHI
  • ,
  • J WIESLANDER
  • ,
  • T HARAMOTO
  • ,
  • K HIRATA
  • ,
  • J WADA
  • ,
  • T YOSHIDA
  • ,
  • K YOSHIOKA
  • ,
  • Z OTA

424
3
開始ページ
235
終了ページ
241
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
SPRINGER VERLAG

The possible involvement of basement membrane-associated collagen (recognized by the monoclonal antibody JK-132) in the evolution of diabetic nephropathy was studied in kidney specimens from seven patients with noninsulin-dependent diabetes mellitus, and its distribution was compared with those of antibodies against alpha 1 to alpha 4 chains of type IV collagen. JK-132, a monoclonal antibody against basement membrane-associated collagen, reacted immunohistochemically exclusively with the mesangial matrix of the glomerular capillary. In contrast, antibodies to the alpha 1 and alpha 2 chains (IV) reacted strongly with mesangial matrix, and less strongly with the glomerular basement membrane (GBM). Antibodies to the alpha 3 and alpha 4 chains (IV) reacted mainly with GBM. In diabetes, JK-132 reacted most extensively with the expanded mesangial matrix, its staining intensity increasing with progression of the diabetic glomerulosclerosis. Antibodies to the al and alpha 2 chains (IV) reacted prominently with the expanded mesangial matrix but less strongly with the GBM. Antibodies to the alpha 3 and alpha 4 chains reacted intensely with the thickened GBM. These results suggest that basement membrane-associated collagen differs from alpha 1 to alpha 4 chains of type IV collagen and that basement membrane-associated collagen is a good marker of mesangial expansion in diabetic nephropathy.


リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994NZ49900002&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-1468-5170
ID情報
  • ISSN : 0945-6317
  • ORCIDのPut Code : 17913183
  • Web of Science ID : WOS:A1994NZ49900002

エクスポート
BibTeX RIS