IKUTA Koichi

J-GLOBAL         Last updated: Sep 25, 2019 at 15:03
 
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Name
IKUTA Koichi
Affiliation
Kyoto University
Section
Institute for Virus Research, Department of biological responses Laboratory of biological protection
Job title
Professor
Degree
Doctor of Medicine(Kyoto University)

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
1987
 - 
1988
Kumamoto University, Research Assistant
 
1988
 - 
1992
Stanford University, Postdoctoral Fellow
 
1992
 - 
1996
University of Tokyo, Associate Professor
 
1996
 - 
2002
 Kyoto University, Associate Professor
 
2002
   
 
-   Kyoto University, Professor
 

Education

 
 
 - 
1987
Graduate School, Division of Medicine, Kyoto University
 
 
 - 
1983
Faculty of Medicine, The University of Tokyo
 

Published Papers

 
Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene.
Mukohira, H., Hara, T., Abe, S., Tani-ichi, S., Sehara-Fujisawa, A., Nagasawa, T., Tobe, K., and Ikuta, K.
Int. Immunol.   in press    2019   [Refereed]
Notch signaling controls transcription via the recruitment of RUNX1 and MYB to enhancers during T cell development
Rodríguez-Caparrós, A., García, V., Casal, Á, López-Ros, J., García-Mariscal, A., Tani-ichi, S., Ikuta, K., and Hernández-Munain, C.
J. Immunol.   202 2460-2472   2019   [Refereed]
Tissue maintenance of CMV-specific inflationary memory T cells by IL-15
Baumann, N., Torti, N., Welten, S. P. M., Barnstorf, I., Borsa, M., Pallmer, K., Oduro, J. D., Cicin-Sain, L., Ikuta, K., Ludewig, B., and Oxenius, A.
PLoS Pathog.   14(4) e1006993   Apr 2018   [Refereed]
Shimba, A., Cui, G., Tani-ichi, S., Ogawa, M., Abe, S., Okazaki, F., Kitano, S., Miyachi, H., Yamada, H., Hara, T., Yoshikai, Y., Nagasawa, T., Schütz, G., and Ikuta, K.
Immunity   48 286-298   Feb 2018   [Refereed]
High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells
Nakamizo, S., Honda, T., Adachi, A., Nagatake, T., Kunisawa, J., Kitoh, A., Otsuka, A., Dainichi, T., Nomura, T., Ginhoux, F., Ikuta, K., Egawa, G., and Kabashima, K.
Sci. Rep.   7 14076   2017   [Refereed]
Gomes, A. C., Hara, T., Lim, V. Y., Herndler-Brandstetter, D., Nevius, E., Sugiyama, T., Tani-ichi, S., Schlenner, S., Richie, E., Rodewald, H., Flavell, R. A., Nagasawa, T., Ikuta, K., and Pereira, J. P.
Immunity   45 1219-1231   2016   [Refereed]
Gil-Cruz, C., Perez-Shibayama, C., Onder, L., Chai, Q., Cupovic, J., Cheng, H., Novkovic, M., Lang, P. A., Geuking, M. B., McCoy, K. D., Abe, S., Cui, G., Ikuta, K., Scandella, E., and Ludewig, B.
Nat. Immunol.   17 1388-1396   2016   [Refereed]
Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.
Proc. Natl. Acad. Sci. USA.   113(20) E2842-E2851   2016   [Refereed]
Terashima, A., Okamoto, K., Nakashima, T., Akira, S., Ikuta, K. and Takayanagi, H.
Immunity   44 1434-1443   2016   [Refereed]
Huang, Y., Getahun, A., Heiser, R. A., Detanico, T. O., Kirchenbaum, G. A., Casper, T. L., Huang, C., Aydintug, M. K., Carding, S. R., Ikuta, K., Huang, H., Wysocki, L. J., Cambier, J. C., O’Brien, R. L., and Born, W. K.
J. Immunol.   196 217-231   2016   [Refereed]
Adachi, T., Kobayashi, T., Sugihara, E., Yamada, T., Ikuta, K., Pittaluga, S., Saya, H., Amagai, M., and Nagao, K.
Nat. Med.   21 1272-1279   2015   [Refereed]
Abe, A., Tani-ichi, S., Shitara, S., Cui, G., Yamada, H., Miyachi, H., Kitano, S., Hara, T., Abe, R., Yoshikai, Y., and Ikuta, K.
J. Immunol.   195 3129-3138   2015   [Refereed]
Alp, Ö. S., Durlanik, S., Schulz, D., McGrath, M., Grün, J. R., Bardua, M., Ikuta, K., Sgouroudis, E., Riedel, R., Zehentmeier, S., Hauser, A. E., Tsuneto, M., Melchers, F., Tokoyoda, K., Chang, H-D., Thiel, A., and Radbruch, A.
Eur. J. Immunol.   45 975-987   2015   [Refereed]
Nishijima, H., Kitano, S., Miyachi, H., Morimoto, J., Kawano, H., Hirota, F., Morita, R., Mouri, Y., Masuda, K., Imoto, I., Ikuta, K., and Matsumoto, M.
J. Immunol.   195 4641-4649   2015   [Refereed]
Huang, Y., Heiser, R. A., Detanico, T. O., Getahun, A., Kirchenbaum, G. A., Aydintug, M. K., Smith, C. W., Carding, S. R., Ikuta, K., Huang, H., Wysocki, L. J., Cambier, J. C., O’Brien, R. L., and Born, W. K.
Proc. Natl. Acad. Sci. USA.   112(1) E39-E48   2015   [Refereed]
Nakamura, M., Shibata, K., Hatano, S., Sato, T., Ohkawa, Y., Yamada, H., Ikuta, K., and Yoshikai, Y.
J. Immunol.   194 243-251   2015   [Refereed]
Wagatsuma, K., Tani-ichi, S., Liang, B., Shitara, S., Ishihara, K., Abe, M., Miyachi, H., Kitano, S., Hara, T., Nanno, M., Ishikawa, H., Sakimura, K., Nakano, M., Kimura, H., and Ikuta, K.
J. Immunol.   195 1804-1814   2015   [Refereed]
G. Cui; T. Hara; S. Simmons; K. Wagatsuma; A. Abe; H. Miyachi; S. Kitano; M. Ishii; S. Tani-Ichi; K. Ikuta
Proceedings of the National Academy of Sciences of the United States of America   111(5) 1915-1920   2014   [Refereed]
M. Tsuneto; E. Kajikhina; K. Seiler; A. Reimer; J. Tornack; C. Bouquet; S. Simmons; M. Knoll; I. Wolf; K. Tokoyoda; A. Hauser; T. Hara; S. Tani-ichi; K. Ikuta; J.R. Grün; A. Grützkau; N. Engels; J. Wienands; Y. Yanagisawa; K. Ohnishi; F. Melchers
Immunology Letters   157(1-2) 60-63   2014   [Refereed]
M. Sekai; S. Tani-ichi; M. Yoneyama; T. Fujita; T. Kina; K. Ikuta
Molecular Immunology   54(3-4) 378-385   Jul 2013   [Refereed]
S. Tani-ichi; A. Shimba; K. Wagatsuma; H. Miyachi; S. Kitano; K. Imai; T. Hara; K. Ikuta
Proceedings of the National Academy of Sciences of the United States of America   110(2) 612-617   Jan 2013   [Refereed]
S. Shitara; T. Hara; B. Liang; K. Wagatsuma; S. Zuklys; G.A. Holländer; H. Nakase; T. Chiba; S. Tani-ichi; K. Ikuta
Journal of Immunology   190(12) 6173-6179   2013   [Refereed]
A. Hanazawa; K. Hayashizaki; K. Shinoda; H. Yagita; K. Okumura; M. Löhning; T. Hara; S. Tani-Ichi; K. Ikuta; B. Eckes; A. Radbruch; K. Tokoyoda; T. Nakayama
Immunology and Cell Biology   91(8) 524-531   2013   [Refereed]
J.-K. Lee; C. Won; E.H. Yi; S.-H. Seok; M.-H. Kim; S.-J. Kim; M.-H. Chung; H.G. Lee; K. Ikuta; S.-K. Ye
Immunology   140(3) 288-300   2013   [Refereed]
M. Tsuneto; K. Tokoyoda; E. Kajikhina; A.E. Hauser; T. Hara; S. Tani-Ichi; K. Ikuta; F. Melchers
Stem Cells   31(12) 2800-2812   2013   [Refereed]
B. Liang; T. Hara; K. Wagatsuma; J. Zhang; K. Maki; H. Miyachi; S. Kitano; C. Yabe-Nishimura; S. Tani-ichi; K. Ikuta
Journal of Immunology   189(9) 4444-4450   Nov 2012   [Refereed]
T. Hara; S. Shitara; K. Imai; H. Miyachi; S. Kitano; H. Yao; S. Tani-ichi; K. Ikuta
Journal of Immunology   189(4) 1577-1584   Aug 2012   [Refereed]
S. Tani-ichi; M. Satake; K. Ikuta
International Immunology   23(9) 553-563   Sep 2011   [Refereed]
T. Shinohara; Y. Nemoto; T. Kanai; K. Kameyama; R. Okamoto; K. Tsuchiya; T. Nakamura; T. Totsuka; K. Ikuta; M. Watanabe
Journal of Immunology   186(4) 2623-2632   Feb 2011   [Refereed]
Y. Ma; L. Aymeric; C. Locher; S.R. Mattarollo; N.F. Delahaye; P. Pereira; L. Boucontet; L. Apetoh; F. Ghiringhelli; N. Casares; J.J. Lasarte; G. Matsuzaki; K. Ikuta; B. Ryffel; K. Benlagha; A. Tesnière; N. Ibrahim; J. Déchanet-Merville; N. Chaput; M.J. Smyth; G. Kroemer; L. Zitvogel
Journal of Experimental Medicine   208(3) 491-503   2011   [Refereed]
Y. Okamoto Yoshida; M. Umemura; A. Yahagi; R.L. O'Brien; K. Ikuta; K. Kishihara; H. Hara; S. Nakae; Y. Iwakura; G. Matsuzaki
Journal of Immunology   184(8) 4414-4422   Apr 2010   [Refereed]
S. Tani-Ichi; H.-C. Lee; S.-K. Ye; K. Ikuta
International Immunology   22(8) 693-703   2010   [Refereed]
A. Tokuriki; T. Iyoda; K. Inaba; K. Ikuta; S. Fujimoto; M. Kumakiri; Y. Yokota
Carcinogenesis   30(9) 1645-1650   Sep 2009   [Refereed]
S. Tani-Ichi; M. Satake; K. Ikuta
International Immunology   21(9) 1079-1088   2009   [Refereed]
MEK1/2 induces STAT5-mediated germline transcription of the TCRγ locus in response to IL-7R signaling
K. Maki; K. Ikuta
Journal of Immunology   181(1) 494-502   Jul 2008   [Refereed]
S. Ogawa; M. Satake; K. Ikuta
Journal of Biochemistry   143(5) 695-709   May 2008   [Refereed]
N. Masui; S. Tani-ichi; K. Maki; K. Ikuta
Molecular Immunology   45(3) 849-855   Feb 2008   [Refereed]
T. Toda; H. Wada; S. Ogawa; S. Tani-ichi; K. Ikuta
Analytical Biochemistry   372(2) 250-252   Jan 2008   [Refereed]
IL-17A produced by γδ T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver
S. Hamada; M. Umemura; T. Shiono; K. Tanaka; A. Yahagi; M.D. Begum; K. Oshiro; Y. Okamoto; H. Watanabe; K. Kawakami; C. Roark; W.K. Born; R. O'Brien; K. Ikuta; H. Ishikawa; S. Nakae; Y. Iwakura; T. Ohta; G. Matsuzaki
Journal of Immunology   181(5) 3456-3463   2008   [Refereed]
Inhibition of NF-κB-mediated TSLP expression by retinoid X receptor
H.-C. Lee; M.B. Headley; M. Iseki; K. Ikuta; S.F. Ziegler
Journal of Immunology   181(8) 5189-5193   2008   [Refereed]
H. Shibata; S. Tani-ichi; H.-C. Lee; K. Maki; K. Ikuta
Immunology Letters   111(1) 45-50   Jul 2007   [Refereed]
C. Nakasone; N. Yamamoto; M. Nakamatsu; T. Kinjo; K. Miyagi; K. Uezu; K. Nakamura; F. Higa; H. Ishikawa; R.L. O'Brien; K. Ikuta; M. Kaku; J. Fujita; K. Kawakami
Microbes and Infection   9(3) 251-258   Mar 2007   [Refereed]
K. Ikuta; R. Kageyama; T. Honjo
IUBMB Life   58(5-6) 258-   2006   [Refereed]
Regulatory role of γδT cells in the recruitment of CD4 + and CD8+ T cells to lung and subsequent pulmonary fibrosis
P.L. Simonian; C.L. Roark; F.D. Del Valle; B.E. Palmer; I.S. Douglas; K. Ikuta; W.K. Born; R.L. O'Brien; A.P. Fontenot
Journal of Immunology   177(7) 4436-4443   2006   [Refereed]
Transcriptional regulation of the mouse IL-7 receptor α promoter by glucocorticoid receptor
H.-C. Lee; H. Shibata; S. Ogawa; K. Maki; K. Ikuta
Journal of Immunology   174(12) 7800-7806   Jun 2005   [Refereed]
S.-K. Ye; T.J. Kim; S.S. Won; T.J. Yoon; T.K. Park; Y.C. Yoo; Y.-N. Kim; H.C. Lee; K. Ikuta; M.-H. Chung; K.H. Lee
Biochemical and Biophysical Research Communications   329(3) 1094-1101   Apr 2005   [Refereed]
N. Watanabe; K. Ikuta; K. Okazaki; H. Nakase; Y. Tabata; M. Matsuura; H. Tamaki; C. Kawanami; T. Honjo; T. Chiba
Digestive Diseases and Sciences   48(2) 408-414   Feb 2003   [Refereed]
Generation of a transgenic animal model of hyperthyroid Graves' disease
Kim-Saijo, M., Akamizu, T., Ikuta, K., Iida, Y., Ohmori, K., Matsubara, K., Matsuda, Y., Suzuki, M., Matsuda, F., and Nakao, K.
Eur. J. Immunol.   33 2531-2538   2003   [Refereed]
N. Watanabe; K. Ikuta; S. Nisitani; T. Chiba; T. Honjo
Journal of Experimental Medicine   196(1) 141-146   Jul 2002   [Refereed]
H. Han; K. Tanigaki; N. Yamamoto; K. Kuroda; M. Yoshimoto; T. Nakahata; K. Ikuta; T. Honjo
International Immunology   14(6) 637-645   Jun 2002   [Refereed]
H.-C. Lee; K. Tomiyama; S.-K. Ye; K. Kawai; K. Ikuta
Immunology Letters   81(3) 211-216   May 2002   [Refereed]
Lahn, M., Kanehiro, A., Takeda, K., Terry, J., Hahn, Y. S., Aydintug, M. K., Konowal, A., Ikuta, K., O'Brien, R. L., Gelfand, E. W., and Born, W. K.
Proc. Natl. Acad. Sci. USA.   99 8850-8855   2002   [Refereed]
Y. Ohba; K. Ikuta; A. Ogura; J. Matsuda; N. Mochizuki; K. Nagashima; K. Kurokawa; B.J. Mayer; K. Maki; J.-I. Miyazaki; M. Matsuda
EMBO Journal   20(13) 3333-3341   Jul 2001   [Refereed]
Induction of germline transcription in the human TCRγ locus by STAT51
H.-C. Lee; S.-K. Ye; T. Honjo; K. Ikuta
Journal of Immunology   167(1) 320-326   Jul 2001   [Refereed]
Y. Agata; T. Katakai; S.-K. Ye; M. Sugai; H. Gonda; T. Honjo; K. Ikuta; A. Shimizu
Journal of Experimental Medicine   193(7) 873-879   Apr 2001   [Refereed]
K. Honda; H. Nakano; H. Yoshida; S. Nishikawa; P. Rennert; K. Ikuta; M. Tamechika; K. Yamaguchi; T. Fukumoto; T. Chiba; S.-I. Nishikawa
Journal of Experimental Medicine   193(5) 621-630   Mar 2001   [Refereed]
Differential roles of cytokine receptors in the development of epidermal γδ T cells
Ye, S.-K., Maki, K., Lee, H.-C., Ito, A., Kawai, K., Suzuki, H., Mak, T. W., Chien, Y., Honjo, T., and Ikuta, K.
J. Immunol.   167 1929-1934   2001   [Refereed]
S.-K. Ye; Y. Agata; H.-C. Lee; H. Kurooka; T. Kitamura; A. Shimizu; T. Honjo; K. Ikuta
Immunity   15(5) 813-823   2001   [Refereed]
S. Fagarasan; K. Kinoshita; M. Muramatsu; K. Ikuta; T. Honjo
Nature   413(6856) 639-643   2001   [Refereed]
Role of the IL-7 receptor in gamma-delta T cell development
K. Ikuta; H.-C. Lee; S.-K. Ye
Chemical Immunology   79 29-42   2001   [Refereed]
S. Fagarasan; R. Shinkura; T. Kamata; F. Nogaki; K. Ikuta; K. Tashiro; T. Honjo
Journal of Experimental Medicine   191(9) 1477-1486   May 2000   [Refereed]
T. Kina; K. Ikuta; E. Takayama; K. Wada; A.S. Majumdar; I.L. Weissman; Y. Katsura
British Journal of Haematology   109(2) 280-287   May 2000   [Refereed]
Depletion of a γδ T cell subset can increase host resistance to a bacterial infection
O'Brien, R. L., Yin, X., Huber, S. A., Ikuta, K., and Born, W. K.
J. Immunol.   165 6472-6479   2000   [Refereed]
N. Watanabe; K. Ikuta; S. Fagarasan; S. Yazumi; T. Chiba; T. Honjo
Journal of Experimental Medicine   192(11) 1577-1586   2000   [Refereed]
Mechanism of B1 cell differentiation and migration in GALT
S. Fagarasan; R. Shinkura; T. Kamata; F. Nogaki; K. Ikuta; T. Honjo
Current Topics in Microbiology and Immunology   252 221-229   2000   [Refereed]
Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA
Kamata, T., Nogaki, F., Fagarasan, S., Sakiyama, T., Kobayashi, I., Miyawaki, S., Ikuta, K., Muso, E., Yoshida, H., Sasayama, S., and Honjo, T.
J. Immunol.   165 1387-1394   2000   [Refereed]
T. Nosaka; T. Kawashima; K. Misawa; K. Ikuta; A.L.-F. Mui; T. Kitamura
EMBO Journal   18(17) 4754-4765   Sep 1999   [Refereed]
H. Yoshida; K. Honda; R. Shinkura; S. Adachi; S. Nishikawa; K. Maki; K. Ikuta; S.-I. Nishikawa
International Immunology   11(5) 643-655   May 1999   [Refereed]
Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment
Watanabe, N., Nisitani, S., Ikuta, K., Suzuki, M., Chiba, T., and Honjo, T.
J. Exp. Med.   190 461-469   1999   [Refereed]
T. Sakiyama; K. Ikuta; S. Nisitani; K. Takatsu; T. Honjo
International Immunology   11(6) 995-1000   1999   [Refereed]
S.-K. Ye; K. Maki; T. Kitamura; S. Sunaga; K. Akashi; J. Domen; I.L. Weissman; T. Honjo; K. Ikuta
Immunity   11(2) 213-223   1999   [Refereed]
Kodaira, Y., Ikuta, K., Tanaka, S., and Yokomuro, Y.
Immunol. Invest.   28 137-148   1999   [Refereed]
Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor
Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W-H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada, M., and Shimizu, T.
J. Exp. Med.   187 1779-1788   1998   [Refereed]
S. Adachi; H. Yoshida; K. Honda; K. Maki; K. Saijo; K. Ikuta; T. Saito; S.-I. Nishikawa
International Immunology   10(1) 1-6   1998   [Refereed]
H. Uozumi; K. Kume; T. Nagase; H. Nakatani; S. Ishii; F. Tashiro; Y. Komagata; K. Maki; K. Ikuta; Y. Ouchi; J.-I. Miyazaki; T. Shimizu
Nature   390(6660) 618-622   Dec 1997   [Refereed]
S. Sunaga; K. Maki; Y. Komagata; K. Ikuta; J.-I. Miyazaki
Molecular Reproduction and Development   46(2) 109-113   Feb 1997   [Refereed]
Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: Similarity to estrogen deficiency
Miyaura C., Onoe, Y., Inada, M., Maki, K., Ikuta, K., Ito, M., and Suda, T.
Proc. Natl. Acad. Sci. USA.   94 9360-9365   1997   [Refereed]
Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor
Ishii, S., Nagase, T., Tashiro, F., Ikuta, K., Sato, S., Waga, I., Kume, K., Miyazaki, J., and Shimizu, T.
EMBO J.   16 133-142   1997   [Refereed]
T. Takeuchi; T. Ueki; S. Sunaga; K. Ikuta; Y. Sasaki; B. Li; N. Moriyama; J.-I. Miyazaki; K. Kawabe
Transplantation   64(1) 152-157   1997   [Refereed]
S. Sunaga; K. Maki; E. Lagasse; J.C.G. Blanco; K. Ozato; J.-I. Miyazaki; K. Ikuta
British Journal of Haematology   96(1) 19-30   1997   [Refereed]
Developmentally Ordered V-J Recombination in Mouse T Cell Receptor γ Locus Is Not Perturbed by Targeted Deletion of the Vγ4 Gene
S. Sunaga; K. Maki; Y. Komagata; J.-I. Miyazaki; K. Ikuta
Journal of Immunology   158(9) 4223-4228   1997   [Refereed]
Y. Komagata; K. Masuko; F. Tashiro; T. Kato; K. Ikuta; K. Nishioka; K. Ito; J.-I. Miyazaki; K. Yamamoto
International Immunology   8(6) 807-814   Jun 1996   [Refereed]
K. Maki; S. Sunaga; Y. Komagata; Y. Kodaira; A. Mabuchi; H. Karasuyama; K. Yokomuro; J.-I. Miyazaki; K. Ikuta
Proceedings of the National Academy of Sciences of the United States of America   93(14) 7172-7177   1996   [Refereed]
Y. Kodaira; K. Yokomuro; S. Tanaka; J.-I. Miyazaki; K. Ikuta
Immunology   87(2) 213-219   1996   [Refereed]
T. Yoshida; K. Ikuta; H. Sugaya; K. Maki; M. Takagi; H. Kanazawa; S. Sunaga; T. Kinashi; K. Yoshimura; J.-I. Miyazaki; S. Takaki; K. Takatsu
Immunity   4(5) 483-494   1996   [Refereed]
Y. Kanamori; K. Ishimaru; M. Nanno; K. Maki; K. Ikuta; H. Nariuchi; H. Ishikawa
Journal of Experimental Medicine   184(4) 1449-1459   1996   [Refereed]
Y. Komagata; I.L. Weissman; K. Ikuta
International Immunology   8(6) 837-845   1996   [Refereed]
K. Maki; S. Sunaga; K. Ikuta
Journal of Experimental Medicine   184(6) 2423-2427   1996   [Refereed]
T. Aoe; Y. Okamoto; H. Arase; K. Ikuta; J.-I. Miyazaki; S. Ono; M. Otuji; H. Ohno; S.-I. Miyatake; T. Saito
International Immunology   8(7) 1055-1066   1996   [Refereed]
H. Ishihara; F. Tashiro; K. Ikuta; T. Asano; H. Katagiri; K. Inukai; M. Kikuchi; Y. Yazaki; Y. Oka; J.-i. Miyazaki
FEBS Letters   371(3) 329-332   1995   [Refereed]
W.H. Fleming; E.J. Alpern; N. Uchida; K. Ikuta; I.L. Weissman
Proceedings of the National Academy of Sciences of the United States of America   90(8) 3760-3764   1993   [Refereed]
W.H. Fleming; E.J. Alpern; N. Uchida; K. Ikuta; G.J. Spangrude; I.L. Weissman
Journal of Cell Biology   122(4) 897-902   1993   [Refereed]
K. Ikuta; I.L. Weissman
Seminars in Developmental Biology   4(6) 371-378   1993   [Refereed]
Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y., and Weissman, I. L.
Ann. N. Y. Acad. Sci.   651 21-32   1992   [Refereed]
K. Ikuta; I.L. Weissman
Proceedings of the National Academy of Sciences of the United States of America   89(4) 1502-1506   1992   [Refereed]
K. Ikuta; N. Uchida; J. Friedman; I.L. Weissman
Annual Review of Immunology   10 759-783   1992   [Refereed]
K. Ikuta; I.L. Weissman
Journal of Experimental Medicine   174(5) 1279-1282   1991   [Refereed]
K. Ikuta; D.E. Ingolia; J. Friedman; S. Heimfeld; I.L. Weissman
International Journal of Cell Cloning   9(5) 451-460   1991   [Refereed]
Mouse hematopoietic stem cells
G.J. Spangrude; L. Smith; N. Uchida; K. Ikuta; S. Heimfeld; J. Friedman; I.L. Weissman
Blood   78(6) 1395-1402   1991   [Refereed]
K. Ikuta; T. Kina; I. MacNeil; N. Uchida; B. Peault; Y.-H. Chien; I.L. Weissman
Cell   62(5) 863-874   Sep 1990   [Refereed]

Books etc

 
Role of the IL-7 receptor in γδ T-cell development from hematopoietic stem cells
Ikuta, K. and Tani-ichi, S.
In “Hematopoietic Stem Cell Biology”. Kondo, M., ed. Humana Press Inc. pp143-159   2009   
Developmental potential of fetal hematopoietic stem cells.
Ikuta, K., and Komagata, Y. (Part:Contributor)
In " Hematopoietic stem cells: Biology and therapeutic applications". Levitt, D. J., and Mertelsmann, R. eds. pp69-83.   1995   

Conference Activities & Talks

 
Intestinal epithelial cell-derived IL-15 supports the homeostasis of intraepithelial lymphocytes
Zhu, Y., Cui, G., and Ikuta, K.
The 25th East Asia Joint Symposium on Biomedical Research   26 Oct 2018   
Competition between STAT5 and PI3K of IL-7R modulates T cell development and homeostasis
Cui, G. and Ikuta, K.
The 25th East Asia Joint Symposium on Biomedical Research   26 Oct 2018   
Glucocorticoids drive diurnal oscillation in T cell distribution and response by inducing interleukin-7 receptor and chemokine receptor CXCR4
Shimba, A., Cui, G., Tani-ichi, S., and Ikuta, K.
The 16th International Student Seminar   1 Mar 2018   
Osteoblasts mediate immunosuppression during sepsis by regulating lymphopoiesis
Terashima, A., Okamoto, K., Nakashima, T., Ikuta, K., and Takayanagi, H.
The 5th Annual Meeting of the International Cytokine and Interferon Society   30 Oct 2017   
IL-7Ra signaling upregulates growth hormone signaling-related gene in naive T cells
Tani-ichi, S., and Ikuta, K.
Keystone Symposium: Integrating Metabolism and Immunity   1 Jun 2017   
Glucocorticoids drive circadian changes in T-cell homing and response via IL-7 receptor
Shimba, A., and Ikuta, K.
Immunology 2017 (AAI)   15 May 2017   
Regulation of IL-7 receptor expression by a proximal enhancer
Shimba, A., Cui, G., Tani-ichi, S., Hara, T., and Ikuta, K.
KTCC 2017   16 Mar 2017   
Competitive signaling between STAT5 and PI3K of IL-7R modulates T cell development and homeostasis in vivo
Cui, G., Shimba, A., Tani-ichi, S., Hara, T., and Ikuta, K.
KTCC 2017   16 Mar 2017   
Identification of bone marrow IL-7 niche critical for B lymphopoiesis
Hara, T., and Ikuta, K.
KTCC 2017   16 Mar 2017   
Roles of IL-7 in development and response of the immune system.
Ikuta, K.
The 11th International Symposium of the Institute Network   27 Jan 2017   
Immunodeficiency caused by sepsis-induced osteoblast ablation
寺島明日香、岡本一男、審良静男、生田宏一、高柳広
第45回日本免疫学会学術集会   Dec 2016   
Local function of the IL-15 niche in thymus
崔広為、榛葉旭恒、阿部真也、朱媛博、向平妃沙、谷一靖江、原崇裕、生田宏一
第45回日本免疫学会学術集会   Dec 2016   
Identification of IL-15 niche for NK cells in bone marrow
阿部真也、原崇裕、崔広為、生田宏一
第45回日本免疫学会学術集会   Dec 2016   
Role of glucocorticoids in T cell homeostasis and T cell response
榛葉旭恒、崔広為、阿部真也、朱媛博、向平妃沙、谷一靖江、原崇裕、生田宏一
The 23rd East Asia Joint Symposium   Oct 2016   
Visualizing the immune microenvironment by reporter mice
生田宏一
富山大学医学研究科大学院セミナー   Oct 2016   
Role of TCRγ enhancer ‘Eγ4’ for the development and function of γδ T cells
谷一靖江、生田宏一
International Congress of Immunology 2016   Aug 2016   
Roles of IL-7 in development and response of the immune system
生田宏一
サバンチ大学セミナー   Jun 2016   
Characterization of the IL-15 niche in vivo
Cui, G., Hara, T., Simmons, S., Ishii, M., Tani-ichi, S., Ikuta, K.
The 6th FIMSA Congress   Jul 2015   
Distribution and function of IL-7- and IL-15-expressing cells in intestines
原崇裕、崔広為、生田宏一
第43回日本免疫学会学術集会、京都、2014年12月12日   2014   
Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex
西嶋仁、森本純子、毛利安宏、河野弘、生田宏一、松本満
第43回日本免疫学会学術集会、京都、2014年12月10日   2014   
Differential roles of IL-7 and IL-2 receptor signals in lymphocyte development and maintenance revealed by IL-7Rα/IL-2Rβ chimera knock-in mice
榛葉旭恒、谷一靖江、増田喬子、原崇裕、河本宏、生田宏一
第43回日本免疫学会学術集会、京都、2014年12月10日   2014   
Identification and characterization of IL-15-expressing cells in vivo
Cui, G., Hara, T., Simmons, S., Wagatsuma, K., Abe, A., Ishii, M., Tani-ichi, S., and Ikuta, K.
The 9th International Symposium of the Institute Network, Osaka, June 19   2014   
Distribution and function of IL-7-expressing cells in intestines
原崇裕、崔広為、設楽宗一朗、生田宏一
第42回日本免疫学会学術集会、千葉、2013年12月11日   2013   
Notch-RBP-Jκ-IL-7Rα pathway plays a pivotal role in the maintenance of IL-17-producing γδ T cells
中村真隆、柴田健輔、山田久方、生田宏一、吉開泰信
第42回日本免疫学会学術集会、千葉、2013年12月11日   2013   
Role of a TCRγ enhancer, Eγ4, in differentiation and function of γδ T cell subsets
谷一靖江、我妻慶祐、生田宏一
第42回日本免疫学会学術集会、千葉、2013年12月11日   2013   
Distribution and function of IL-7-expressing cells in large intestine
Hara, T. and Ikuta, K.
The 4th Workshop on Synthetic Immunology, Kyoto, November 16   2013   
Identification and characterization of the IL-15-expressing cells in vivo
Cui, G., Hara, T., Simmons, S., Wagatsuma, K., Tani-ichi, S., Ishii, M., and Ikuta, K.
The 20th East Asia Joint Symposium on Global Medical Science for the 22th Century, Tokyo, November 7   2013   
Visualizing the immune microenvironment by reporter mice
Ikuta, K., Cui, G., Shitara, S., Liang, B., Tani-ichi, S., and Hara, T.
The 20th East Asia Joint Symposium on Global Medical Science for the 22th Century, Tokyo, November 7   2013   
Distribution and function of IL-7-expressing cells in the intestinal tissues
Hara, T. and Ikuta, K.
The 8th International Symposium of the Institute Network, Kyoto, June 27   2013   
Differential roles of Jγ promoters and Eγ enhancers in controlling chromatin accessibility of the TCRγ locus by STAT5
Wagatsuma, K., Tani-ichi, S., Shimba, A., Liang, B., Shitara, S., Hara, T., and Ikuta, K.
The 6th International Workshop of Kyoto T Cell Conference 2013, Kyoto, June 4-5   2013   
Visualization and characterization of IL-7- and IL-15-expressing cells in vivo
Hara, T., Cui, G., Shitara, S., Tani-ichi, S. and Ikuta, K.
The 6th International Workshop of Kyoto T Cell Conference 2013, Kyoto, June 4-5   2013   
Visualization of the immune microenvironment by reporter mice
Ikuta, K., Cui, G., Shitara, S., Liang, B., Tani-ichi, S., and Hara, T.
The 6th International Workshop of Kyoto T Cell Conference 2013, Kyoto, June 7   2013   
STAT5 motifs in the T cell receptor Jγ promoters control the local chromatin accessibility and rearrangements of the Jγ gene segments
Wagatsuma, K., Tani-ichi, S., Liang, B., Shitara, S., Miyachi, H., Kitano, S., Kimura, H., Hara, T., and Ikuta, K.
The 11th International Student Seminar, Kyoto, March 5-6   2013   
Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes
Shitara, S., Hara, T., Liang, B., Wagatsuma, K., Tani-ichi, S., and Ikuta, K.
The 11th International Student Seminar, Kyoto, March 5-6   2013   
Differential role of IL-7 and IL-2 receptor signals in development and maintenance of lymphocytes revealed by IL-7Rα/IL-2Rβ chimera knock-in mouse
Shimba, A., Tani-ichi, S., and Ikuta, K.
The 11th International Student Seminar, Kyoto, March 5-6   2013   
Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance
西嶋仁、森本純子、毛利安宏、西川裕美子、生田宏一、松本満
第42回日本免疫学会学術集会、千葉、2013年12月11日   2013   
Notch-RBP-JK-IL-7 receptor alpha axis is essential for the maintenance of IL- 17-producing ys T cells
柴田健輔,中村真隆,山田久方,生田宏一,吉開泰信
第41 回 日本免疫学会学術集会、神戸、2012 年12 月7 日   2012   
Interleukin-7 produced by thymic epithelial cells controls development and maturation of thymocytes
設楽宗一朗,原崇裕,生田宏一
第41 回日本免疫学会学術集会、神戸、2012 年12 月6 日   2012   
Visualization and characterization of IL-15-expressing cells in vivo by IL-15-CFP knock-in mice
崔広為,原崇裕,我妻慶祐,生田宏一
第41 回日本免疫学会学術集会、神戸、2012 年12 月5 日   2012   
Enhancers control locus-wide accessibility of the TCRy locus in vivo
我妻慶祐,谷一靖江,生田宏一
第41 回日本免疫学会学術集会、神戸、2012 年12 月5日   2012   
Local function of IL-7 produced by hepatocytes.
Liang B., Hara T., Wagatsuma K., Shitara S., Tani-ichi S., Ikuta K.
The 10th International Student Seminar, Kyoto, March 5-8, 2012 ・   2012   
Distribution and function of IL-7-producing cells in lymphoid organs.
Ikuta K., Hara T., Liang B., Cui G., Wagatsuma K., Tani-ichi S.
The Global COE Liaison Laboratory regular seminar, Kumamoto, July 18, 2012 .   2012   
Distribution and function of IL-7-expressing cells in lymphoid organs.
生田宏一
岐阜大学医学研究科大学院セミナー, 岐阜, 2011年9月9日   2011   
STAT motifs in Jγ promoters are essential for Vγ-Jγ rearrangements of Jγ gene segments.
Wagatsuma K., Tani-ichi S., Ikuta K.
The 9th International Student Seminar, Kyoto, March 7-9, 2011.   2011   
IL-7 signal controls differentiation of CD8 T cells and maintenance of peripheral T cells.
Abe A, Tani-ichi S, Ikuta K
The 14th International Congress of Immunology, Kobe, August 25, 2010   2010   
Accessibility of the TCRy locus by a chromatin remodeling factor BRG1.
Sumi C., Tani-ichi S., and Ikuta K.,
The 7th International Student Seminar, Kyoto, March 12, 2009 ・   2009   
Production of IL-7 by lymphocyte-stromal cell crosstalk
SEKAI Miho, KINA Tatsuo, IKUTA Koichi
第37 回日本免疫学会総会・学術集会(2007.11.20-22.東京)   2007   
Control of the TCRγ Locus Accessibility by Stat5 and Histone Modifications.
Ikuta. K.
The 14th East Asia Joint Symposium on Biomedical Research. The Institute of Medical Science, the University of Tokyo, Tokyo, November 13, 2007.   2007   
Bone marrow transplantation with newborn thymus grafts can rescue superlethally irradiated mice: possible role of IL-7-dependent mechanism.
Hosaka N., Miyake T., Cui W., Nishida A., Takagi T., Inaba M., Ikuta K., Ikehara S.
第36 回日本免疫学会学術集会, 大阪, 12月12日, 2006.   2006   
Id2-deficient mice are susceptible to skin tumorigenesis but resistant to tumor proliferation.
Tokuriki A., Ikuta K., Yokota Y.
The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, June 22, 2006.   2006   
The IL-7 receptor controls the accessibility of the TCRγ locus by MAPK pathway
Maki K., Hayashi S., Ikuta K.
The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, June 21, 2006.   2006   
Role of IL-7 receptor during lymphocyte development.
Lee H. C., Shibata H., Ogawa S., Maki K., Ikuta K.
The 2nd RCAI Workshop "Epigenetic Regulation during Immune System Development", Yokohama, April 15, 2005.   2005   
Regulation of IL-7 receptor expression during T cell development.
Ogawa S., Shibata H., Lee H. C., Maki K., Ikuta K.
The 4th International Workshop of Kyoto T Cell Conference, Kyoto, April 8, 2005.   2005   

Research Grants & Projects

 
Mechanism of lymphocyte differentiation and proliferation by IL-7 receptor-deficient mice