2003年11月
Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
HEPATOLOGY
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- 巻
- 38
- 号
- 5
- 開始ページ
- 1282
- 終了ページ
- 1288
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1053/jhep.2003.50449
- 出版者・発行元
- W B SAUNDERS CO
Persistent infection of hepatitis C virus (HCV) is a major cause of liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Searching for a substance with anti-HCV potential, we examined the effects of a variety of compounds on HCV replication using a HCV subgenomic replicon cell culture system. Consequently, the immunosuppressant cyclosporin A (CsA) was found to have a suppressive effect on the HCV replicon RNA level and HCV protein expression in these cells. CsA also inhibited multiplication of the HCV genome in a cultured human hepatocyte cell line infected with HCV using HCV-positive plasma. This anti-HCV activity of CsA appeared to be independent of its immunosuppressive function. In conclusion, our results suggest that CsA may represent a new approach for the development of anti-HCV therapy.
- リンク情報
- ID情報
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- DOI : 10.1053/jhep.2003.50449
- ISSN : 0270-9139
- PubMed ID : 14578868
- Web of Science ID : WOS:000186390800025