MISC

1999年1月

Change of expression of full-length and truncated TrkBs in the developing monkey central nervous system

DEVELOPMENTAL BRAIN RESEARCH
  • K Ohira
  • ,
  • K Shimizu
  • ,
  • M Hayashi

112
1
開始ページ
21
終了ページ
29
記述言語
英語
掲載種別
DOI
10.1016/S0165-3806(98)00151-5
出版者・発行元
ELSEVIER SCIENCE BV

We examined the expression of full-length TrkB (TrkB(TK+)) and truncated TrkB (TrkB(TK-)) in the central nervous system (CNS) of the macaque monkey (Macaca fascicularis) using a western blot analysis. Ar the adult stage, the levels of TrkB(TK+) in cerebral cortices were higher than those in other structures of CNS and the expressions of TrkB(TK+) in the association cortices (except area PE) were relatively lower than those in the primary cortices. In contrast, TrkB(TK-) in the hjppocampus and the cerebellum was significantly higher than in other structures. in various developing cerebral cortices, TrkB(TK+) was detected at the same levels from embryonic day 120 (E120) to the adult period. In contrast, the expression of TrkB(TK-) increased remarkably after the newborn stage (NB), reached the maximum level at postnatal day 60 (P60) and maintained the same level into adulthood. The peaks of TrkB(TK-) in the association cortices were more delayed than in the primary cortices. The expression of TrkB(TK-) occurred at a time that correlates with the elimination of axons and the down-regulation of neuropeptides. The present study suggests that TrkB(TK-) plays an important role in the axonal remodelling and that it may act as a negative effector of TrkB(TK+), the primate CNS, reducing responsiveness to BDNF and/or NT-4/5. (C) 1999 Elsevier Science B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/S0165-3806(98)00151-5
CiNii Articles
http://ci.nii.ac.jp/naid/10011213621
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9974156
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000078096000003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0165-3806(98)00151-5
  • ISSN : 0165-3806
  • CiNii Articles ID : 10011213621
  • PubMed ID : 9974156
  • Web of Science ID : WOS:000078096000003

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