1999年1月
Change of expression of full-length and truncated TrkBs in the developing monkey central nervous system
DEVELOPMENTAL BRAIN RESEARCH
- ,
- ,
- 巻
- 112
- 号
- 1
- 開始ページ
- 21
- 終了ページ
- 29
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0165-3806(98)00151-5
- 出版者・発行元
- ELSEVIER SCIENCE BV
We examined the expression of full-length TrkB (TrkB(TK+)) and truncated TrkB (TrkB(TK-)) in the central nervous system (CNS) of the macaque monkey (Macaca fascicularis) using a western blot analysis. Ar the adult stage, the levels of TrkB(TK+) in cerebral cortices were higher than those in other structures of CNS and the expressions of TrkB(TK+) in the association cortices (except area PE) were relatively lower than those in the primary cortices. In contrast, TrkB(TK-) in the hjppocampus and the cerebellum was significantly higher than in other structures. in various developing cerebral cortices, TrkB(TK+) was detected at the same levels from embryonic day 120 (E120) to the adult period. In contrast, the expression of TrkB(TK-) increased remarkably after the newborn stage (NB), reached the maximum level at postnatal day 60 (P60) and maintained the same level into adulthood. The peaks of TrkB(TK-) in the association cortices were more delayed than in the primary cortices. The expression of TrkB(TK-) occurred at a time that correlates with the elimination of axons and the down-regulation of neuropeptides. The present study suggests that TrkB(TK-) plays an important role in the axonal remodelling and that it may act as a negative effector of TrkB(TK+), the primate CNS, reducing responsiveness to BDNF and/or NT-4/5. (C) 1999 Elsevier Science B.V. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/S0165-3806(98)00151-5
- CiNii Articles
- http://ci.nii.ac.jp/naid/10011213621
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/9974156
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000078096000003&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/S0165-3806(98)00151-5
- ISSN : 0165-3806
- CiNii Articles ID : 10011213621
- PubMed ID : 9974156
- Web of Science ID : WOS:000078096000003