The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinaseC pathway (Molecular and cellular biology - [16/,6752-6764])
Expression of oncogene products and growth factors in early gallbladder cancer, advanced gallbladder cancer, and chronic cholecystitis, Human Pathology 24 37-40
A yeast-based phenotypic screen for ERK signaling modulators
Reiko Sugiura
German Japanese Workshop on Frontiers in Phosphatase Research and Drug Development 22 Oct 2018
The Cutting Edge of Cancer Research -Approaching towards "Genome-based Drug Discovery"[Invited]
Reiko Sugiura
20 Aug 2018
Selective killing of cancer cells by ACA-28, a small molecule inducing ERK-dependent apoptosis: ~ A novel cancer therapy to stimulate oncogenic ERK signaling~
Chemical genetics identifies ACA-28, a 1′-acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells by inducing ERK-dependent apoptosis
Reiko Sugiura
The 8th Japanese Conference on Protein Phosphatase / The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase 18 Nov 2017
The DEAD box RNA helicase Ded1 negatively regulates PKC/MAPK signaling via RNA granule
RNA Biology 2017 ~Cutting Edge Developments in RNA Biology for the Control of Gene Expression~ 13 Nov 2017
Selective Killing of Human Melanoma Cancer Cells by a Novel Small Molecule Compound Identified by a Phenotypic Screen Targeting MAPK Signalling in Fission Yeast
Applying Kinase-Phosphatase Interplay in Ca2+ signaling for Cancer Therapeutics: A pas de deux
Reiko Sugiura
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Skb5, an SH3 adaptor protein, regulates PKC/MAPK signaling via spatial regulation of MAPKKK
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Anticancer-drug screening utilizing fission yeast genetics identified Acremomannolipin A, a Calcium signalling modulator with anti-tumor activity
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Protein kinase N (PKN) family-dependent regulation of hepatic cytochrome P450 2C and metabolic profile analysis in PKN mutant mice through targeted metabolomics by LC-MS/MS
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Mutation and Inhibition of Hsp90 affects stress granule assembly and MAPK signaling ~Implications of anti-cancer mechanisms of Geldanamycin~
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Skb5, an SH3 domain adaptor protein, plays a regulatory role in the PKC/MAPK signaling pathway by controlling the intracellular localization of the MAPKKK Mkh1
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Global gene expression profiling reveals unexpected spectrum of effects of a novel immune modulator FTY720 ~Possible involvement of iron homeostasis as an antitumor property of FTY720~
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Anti-cancer drug discovery using fission yeast genetics identified a novel analog of 1’-Acetoxychavicol Acetate (ACA) with a potent anti-tumor activity against human melanoma cells
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Functional Analysis of the Puf family RNA-binding protein Pumilio in stress responses and the inositol phospholipid signaling pathway
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
Evaluation of the measurement method of intracellular calcium ion concentration in fission yeast
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
A Genome-wide Screen Reveals Genes Involved in Calcium Signaling and Glycosylation for Tolerance to SKB (Sugiura Kagobutsu B), a Novel Glycolipid with Potent Anti-tumor Activity
12th International Conference on Protein Phosphatase and International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics 27 Oct 2016
We identified the mRNA-binding protein Nrd1 and demonstrated that Nrd1 binds to and regulates mRNA stability of the Myosin mRNA. We also showed that Pmk1 MAPK, a homologue of ERK in fission yeast regulates the RNA-binding activity of Nrd1 in a ph...
This project aims to identify regulators of MAPK signaling using fission yeast S. pombe as a model organism. We identified negative regulators of Pmk1 MAPK, such as ptc1+, ptc3+, encoding PP2Cs, and ecm33+, encoding a cell surface protein. We also...
This research aims to unravel the regulatory mechanisms of the signal transduction pathway regulated by RNA-binding proteins. We utilized the fission yeast model system and molecular genetic approach to identify RNA binding proteins that regulate ...
Calcineurin (protein phosphatase 2B), the only serine/threonine phosphatase under the control of Ca2+/calmodulin, is an important mediator in signal transmission, connecting the Ca2+-dependent signalling to a wide variety of cellular responses. Ca...
