MISC

2001年6月

beta-estradiol 3-benzoate affects spermatogenesis in the adult mouse

MOLECULAR AND CELLULAR ENDOCRINOLOGY
  • Y Toyama
  • ,
  • Hosoi, I
  • ,
  • S Ichikawa
  • ,
  • M Maruoka
  • ,
  • E Yashiro
  • ,
  • H Ito
  • ,
  • S Yuasa

178
1-2
開始ページ
161
終了ページ
168
記述言語
英語
掲載種別
DOI
10.1016/S0303-7207(01)00419-1
出版者・発行元
ELSEVIER SCI IRELAND LTD

beta -estradiol 3-benzoate (E2B) (10, 16, 20, 40, 80 and 160 mug/kg body weight) was administered daily to experimental groups of adult mice For the following periods; 2, 3 days, 1, 2, 4, and 8 weeks. Morphological changes in the testes were observed by both light and electron microscopy. Exfoliation of the germ cells was observed in the lumen of the seminiferous tubule. The spermatogenic cycle, especially stage XII, was disordered. Spermatids older than step 6 were severely affected. Detected abnormalities in the spermatids were deformation of the nucleus and autosome. Partial deletion in the Sertoli-spermatid ectoplasmic specialization was also observed. Germ cells younger than step 7 spermatids were not affected morphologically. These abnormalities were not detected in the mice treated with the chemical at less than 16 mug/kg body weight. It is concluded that the chemical seems to affect round spermatids metabolically, but the morphological effect can be detected only from the spermatids older than step 6. The effects of the chemical on adult mice were reversible. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 33

リンク情報
DOI
https://doi.org/10.1016/S0303-7207(01)00419-1
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000169484000020&DestApp=WOS_CPL

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