論文

査読有り
2016年11月

Inhibition of amyloid β protein fibrillation via carboxypeptidase Y after protein trapping using immunoaffinity membranes

Chemistry Letters
  • Masaki Saito
  • ,
  • Tamotsu Zako
  • ,
  • Ryoji Takahashi
  • ,
  • Youji Shimazaki

45
11
開始ページ
1241
終了ページ
1243
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1246/cl.160613

© 2016 The Chemical Society of Japan. In this study, we firstly report inhibition of amyloid β 42 (Aβ 42 ) fibrillation, which is related to the progression of Alzheimer's disease, by digestion using proteases, combined with Aβ 42 isolation using an immunoaffinity membrane. Especially, digestion of Aβ 42 with carboxypeptidase Y (CPY) is effective for the inhibition of Aβ 42 fibrillation, indicating that carboxy-terminal digestion of Aβ 42 is efficient for the prevention of its fibrillation. The combinational method of the immunoaffinity membrane with CPY digestion is applicable to suppress Aβ 42 fibrillation.

リンク情報
DOI
https://doi.org/10.1246/cl.160613
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000386832600005&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84994008736&origin=inward
ID情報
  • DOI : 10.1246/cl.160613
  • ISSN : 0366-7022
  • eISSN : 1348-0715
  • SCOPUS ID : 84994008736
  • Web of Science ID : WOS:000386832600005

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