2016年11月
Inhibition of amyloid β protein fibrillation via carboxypeptidase Y after protein trapping using immunoaffinity membranes
Chemistry Letters
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- ,
- ,
- 巻
- 45
- 号
- 11
- 開始ページ
- 1241
- 終了ページ
- 1243
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1246/cl.160613
© 2016 The Chemical Society of Japan. In this study, we firstly report inhibition of amyloid β 42 (Aβ 42 ) fibrillation, which is related to the progression of Alzheimer's disease, by digestion using proteases, combined with Aβ 42 isolation using an immunoaffinity membrane. Especially, digestion of Aβ 42 with carboxypeptidase Y (CPY) is effective for the inhibition of Aβ 42 fibrillation, indicating that carboxy-terminal digestion of Aβ 42 is efficient for the prevention of its fibrillation. The combinational method of the immunoaffinity membrane with CPY digestion is applicable to suppress Aβ 42 fibrillation.
- リンク情報
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- DOI
- https://doi.org/10.1246/cl.160613
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000386832600005&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84994008736&origin=inward
- ID情報
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- DOI : 10.1246/cl.160613
- ISSN : 0366-7022
- eISSN : 1348-0715
- SCOPUS ID : 84994008736
- Web of Science ID : WOS:000386832600005