Yasumitsu OGRA

Profile Information

Affiliation: Professor, Graduate School of Pharmaceutical Sciences, Chiba University
: (Concurrent)

Degree: Ph. D.(Pharmaceutical Sciences)(Chiba University)

J-GLOBAL ID: 200901033762535827
Researcher ID: A-2747-2017
researchmap Member ID: 1000222029

External link: http://www.p.chiba-u.jp/lab/yobou/index.html

東京都練馬区出身。

Research Interests

生体微量元素 biometals スペシエーション speciation 銅 copper セレン selenium ミネラル mineral 栄養補助食品 supplements ICP-MS ICP-MS キャピラリーHPLC capillary HPLC 質量分析 mass spectrometry
biometals speciation copper selenium mineral supplements ICP-MS capillary HPLC mass spectrometry

Research Areas

Research History

Mar, 2025 - Present

客員研究員, 食品部, 国立医薬品食品衛生研究所
Apr, 2024 - Present

Dean, Graduate School of Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences, Chiba University
Oct, 2023 - Present

Associate Member, Science Council of Japan
Apr, 2016 - Present

Professor, Graduate School of Pharmaceutical Sciences, Chiba Univesity
Apr, 2023 - Mar, 2024

Dean, Graduate School of Medical and Pharmaceutical Sciences, Chiba University
Mar, 2015 - Mar, 2016

Professor, Graduate School of Pharmaceutical Sciences, Chiba University
Apr, 2009 - Feb, 2015

Professor, Showa Pharmaceutical University

Education

- Mar, 1996

Graduate School of Pharmaceutical Sciences, Chiba University
- Mar, 1991

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Awards

Sep, 2024

学会賞, 日本微量元素学会

小椋康光
Jul, 2023

JSOT Award, The Japanese Society of Toxicology

Yasumitsu Ogra
Sep, 2016

学術賞, 日本薬学会環境・衛生部会

小椋康光
Jun, 2016

日化協LRI賞, 日本毒性学会

小椋康光
Mar, 2014

学術振興賞, 日本薬学会

小椋康光
Jun, 2013

Fellow, Royal Society of Chemistry

Yasumitsu OGRA
Jul, 2007

奨励賞, 日本微量元素学会

小椋康光
Sep, 2002

Best oral presentation prize / 2nd Franco-Spanish workshop on Bio-Inoiganic Anarytial Chemistry
Nov, 2001

メタロチオネイン奨励賞
2001

Young Scientist Award for Metallothionein

Papers

224

The polar-localized borate exporter BOR1 facilitates boron transport in tapetal cells to the developing pollen grains.

Keita Muro, Arisa Yamasaki, Maki Matsumoto, Yu-Ki Tanaka, Yasumitsu Ogra, Toru Fujiwara, Akira Yoshinari, Junpei Takano

Plant physiology, Mar 19, 2025
Laser Ablation Coupled with LC-ICP-MS for Local Speciation of Trace Elements in Tissues.

Makiko Iwase, Yu-Ki Tanaka, Yasunori Fukumoto, Noriyuki Suzuki, Yasumitsu Ogra

Analytical chemistry, 97(9) 5306-5312, Mar 11, 2025
Evaluation of Metal Accumulation in Escherichia coli Expressing SPL2 by Single-Cell Inductively Coupled Plasma Mass Spectrometry.

Yasunori Fukumoto, Enhui Li, Yu-Ki Tanaka, Noriyuki Suzuki, Yasumitsu Ogra

International journal of molecular sciences, 26(5), Feb 22, 2025
Analytical techniques for arsenic speciation.

Yu-Ki Tanaka, Kemmu Matsuhashi, Yasumitsu Ogra

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, Jan 31, 2025
Quantitative elemental analysis of human leukemia K562 single cells by inductively coupled plasma mass spectrometry in combination with a microdroplet generator

Yu-ki Tanaka, Hinano Katayama, Risako Iida, Yasumitsu Ogra

Journal of Analytical Atomic Spectrometry, 2025
Thiopurine S‑methyltransferase- and indolethylamine N‑methyltransferase-mediated formation of methylated tellurium compounds from tellurite.

Yu-Ki Tanaka, Ayuka Takata, Karin Takahashi, Yoshikazu Yamagishi, Yasunori Fukumoto, Noriyuki Suzuki, Yasumitsu Ogra

Archives of toxicology, Oct 17, 2024
Single-Cell Analysis of Elemental Contents by Laser Ablation-Inductively Coupled Plasma Mass Spectrometry.

Yu-Ki Tanaka, Yasumitsu Ogra

Journal of the American Society for Mass Spectrometry, 35(9) 2082-2089, Sep 4, 2024
Elucidation of γ-glutamyl-β-cyanoalanylglycine biosynthesis in mammalian cells by LC-QTOF-MS

Ryu Mochizuki, Yoshikazu Yamagishi, Yasumitsu Ogra

Toxicological Sciences, Aug 21, 2024 Peer-reviewed
メタボローム解析によるヒト肝がん細胞(HepG2)における低温ストレス応答機構の解明

福田彩乃, 山岸由和, 永澤明佳, 小椋康光

The Journal of Toxicological Sciences, 49(Suppl.) S100-S100, Jul, 2024
ヘモグロビンによるアムロジピンの死後分解

山岸由和, 永澤明佳, 岩瀬博太郎, 小椋康光

The Journal of Toxicological Sciences, 49(Suppl.) S195-S195, Jul, 2024
法医解剖となった職場における化学物質による死亡事例の検討

永澤明佳, 山岸由和, 井上博之, 千葉文子, 猪口剛, 槇野陽介, 矢島大介, 岩瀬博太郎, 小椋康光

中毒研究, 37(2) 255-255, Jul, 2024
Protein-Labeling Reagents Selectively Activated by Copper(I).

Rong Cheng, Yuki Nishikawa, Takumi Wagatsuma, Taiho Kambe, Yu-Ki Tanaka, Yasumitsu Ogra, Tomonori Tamura, Itaru Hamachi

ACS chemical biology, 19(6) 1222-1228, Jun 21, 2024
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.

Hiroaki Fujita, Yu-Ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, Kazuhiro Iwai

Nature structural & molecular biology, Jun 12, 2024
Identification of Tellurium Metabolite in Broccoli Using Complementary Analyses of Inorganic and Organic Mass Spectrometry.

Shohei Takada, Yoshikazu Yamagishi, Yu-Ki Tanaka, Yasumi Anan, Sayaka Nagasawa, Hirotaro Iwase, Yasumitsu Ogra

Chemical research in toxicology, Jun 10, 2024
Role of sulfane sulfur species in elemental tellurium nanorod formation in mammalian cells

Yu-ki Tanaka, Hiroki Yanagi, Ayako Shiokawa, Akihiro Matsunaga, Mari Shimura, Satoshi Matsuyama, Yasunori Fukumoto, Noriyuki Suzuki, Yasumitsu Ogra

Redox Biochemistry and Chemistry, 8 100029-100029, Jun, 2024
Development of a Biosafety Level 1 Cellular Assay for Identifying Small-Molecule Antivirals Targeting the Main Protease of SARS-CoV-2: Evaluation of Cellular Activity of GC376, Boceprevir, Carmofur, Ebselen, and Selenoneine

Yasunori Fukumoto, Noriyuki Suzuki, Reina Hara, Yu-ki Tanaka, Yasumitsu Ogra

International Journal of Molecular Sciences, 25(11) 5767-5767, May 25, 2024
Quantitative determination of the intracellular uptake of silica nanoparticles using asymmetric flow field flow fractionation coupled with ICP mass spectrometry and their cytotoxicity in HepG2 cells.

Yu-Ki Tanaka, Yasumitsu Ogra

Archives of toxicology, 98(3) 769-777, Mar, 2024
Evaluation of organophosphorus pesticide tyrosine adducts for post-mortem change by human serum albumin with liquid chromatography quadrupole orbitrap mass spectrometry.

Yoshikazu Yamagishi, Sayaka Nagasawa, Hirotaro Iwase, Yasumitsu Ogra

Toxicological sciences : an official journal of the Society of Toxicology, Feb 17, 2024
Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion

Yasunori Fukumoto, Rin Kyono, Yuka Shibukawa, Yu-ki Tanaka, Noriyuki Suzuki, Yasumitsu Ogra

Journal of Biological Chemistry, 300(2) 105599-105599, Feb, 2024
Subchronic toxicity study of indium-tin oxide nanoparticles following intratracheal administration into the lungs of rats.

Nagisa Matsumura, Yu-Ki Tanaka, Yasumitsu Ogra, Kazunori Koga, Masaharu Shiratani, Kasuke Nagano, Akiyo Tanaka

Journal of occupational health, 66(1), Jan 4, 2024

Misc.

Mechanism of cold stress response in human hepatocarcinoma cells (HepG2)

福田彩乃, 山岸由和, 永澤明佳, 永澤明佳, 小椋康光, 小椋康光

衛生薬学・環境トキシコロジー講演要旨集, 2024, 2024
Post-mortem degradation of flunitrazepam in blood

山岸由和, 井上博之, 永澤明佳, 永澤明佳, 岩瀬博太郎, 小椋康光, 小椋康光

衛生薬学・環境トキシコロジー講演要旨集, 2024, 2024
Determination of Acylcarnitines as a Biomarker of Insulin Poisoning by LC-QTOF/MS

片山愛美, 永澤明佳, 岩瀬博太郎, 小椋康光

衛生薬学・環境トキシコロジー講演要旨集, 2024, 2024
Investigation of postmortem fatal concentration of escitalopram.

永澤明佳, 永澤明佳, 千葉文子, 千葉文子, 鳥光優, 鳥光優, 山岸由和, 猪口剛, 猪口剛, 槇野陽介 …

日本薬学会年会要旨集(Web), 144th, 2024
Development of toxicological biomarkers originating from human serum albumin for organophosphorus pesticides

山岸由和, 永澤明佳, 永澤明佳, 岩瀬博太郎, 小椋康光, 小椋康光

日本薬学会年会要旨集(Web), 144th, 2024
Degradation of antimicrobial agents by radical species generated from multi-gas plasma jet

田中佑樹, 小椋康光, 山岸由和, 大澤泰樹, 沖野晃俊

生体医歯工学共同研究拠点成果報告書, 2023, 2024
Post-mortem change of zolpidem in blood with hemoglobin

山岸由和, 永澤明佳, 永澤明佳, 岩瀬博太郎, 小椋康光, 小椋康光

日本薬学会年会要旨集(Web), 143rd, 2023
カドミウムの肝臓への蓄積および毒性発現に対するリポカリン分子C8γの機能解析

山本勝也, 山本勝也, 石田慶士, 松丸大輔, 田中佑樹, 小椋康光, 中西剛

Fundamental Toxicological Sciences (Web), 10(Supplement), 2023
植物中新規テルル酸代謝物の同定及び毒性評価

高田翔平, 山岸由和, 永澤明佳, 永澤明佳, 小椋康光

Fundamental Toxicological Sciences (Web), 10(Supplement), 2023
セレン含有化合物の選択的検出法の開発

山岸由和, 高橋一聡, 永澤明佳, 永澤明佳, 岩瀬博太郎, 小椋康光, 小椋康光

Fundamental Toxicological Sciences (Web), 10(Supplement), 2023
インジウム・スズ酸化物ナノ粒子の体内動態に及ぼすサイズ効果

田中昭代, 松村渚, 田中佑樹, 小椋康光, 古閑一憲, 白谷正治, 長野嘉介

大気環境学会年会講演要旨集, 63回 3D1030-3D1030, Sep, 2022
インジウム・スズ酸化物ナノ粒子の皮下投与による亜慢性影響

松村渚, 田中佑樹, 小椋康光, 古閑一憲, 白谷正治, 長野嘉介, 田中昭代

Biomedical Research on Trace Elements, 33(1) 137-137, Sep, 2022
乳歯切片中の元素分布に影響を及ぼす要因の探索

久田文, 江口哲史, 山本緑, 櫻井健一, 戸高恵美子, 田中佑樹, 鈴木紀行, 小椋康光, 森千里

日本衛生学雑誌(Web), 77(Supplement), 2022
ヘモグロビン中の鉄を介したヒト血液中パリペリドンの死後代謝の解析

山岸由和, 猪口剛, 星岡佑美, 永澤明佳, 永澤明佳, 岩瀬博太郎, 小椋康光, 小椋康光

Fundamental Toxicological Sciences (Web), 9(Supplement), 2022
Hyperthermia Selectively Destabilizes Oncogenic Fusion Proteins

Yasen Maimaitiyiming, Qian Qian Wang, Chang Yang, Yasumitsu Ogra, Yinjun Lou, Clayton A. Smith, Liaqat Hussain, Yi Ming Shao, Jiebo Lin, Jinfeng Liu …

Cancer discovery, 2(4) 388-401, Jul 1, 2021
Nutritional availability of biogenic Se-nanoparticles in rats

高橋一聡, 高橋一聡, 越智杏奈, 三原久明, 小椋康光

日本薬学会年会要旨集(Web), 141st, 2021
千葉大学・東京大学で実施した交通解剖事例の薬物使用調査

安部寛子, 岡村和子, 大屋夕希子, 槇野陽介, 藤田悟郎, 小菅律, 中野友香子, 小椋康光, 岩瀬博太郎

日本法医学雑誌, 73(1) 87-87, May, 2019
LA-ICP-MSを用いた乳歯切片中の多元素分析

久田文, 江口哲史, 山本緑, 櫻井健一, 戸高恵美子, 田中佑樹, 鈴木紀行, 小椋康光, 森千里

日本衛生学雑誌, 74(Suppl.) S148-S148, Feb, 2019
LA-ICP-MSを用いた乳歯切片中の多元素分析

久田文, 江口哲史, 山本緑, 櫻井健一, 戸高恵美子, 田中佑樹, 鈴木紀行, 小椋康光, 森千里

日本衛生学雑誌(Web), 74(Supplement), 2019
Detoxification of tellurate in Allium sativum by forming biogenic nanoparticles

高田翔平, 田中佑樹, 熊谷和博, 保倉明子, 小椋康光

Biomedical Research on Trace Elements, 30(2), 2019

Books and Other Publications

病の錬金術化学物質はなぜ毒になりうるのか (ニュートン新書)

日向, やよい, 小椋, 康光 (Role: Supervisor (editorial)) (Original Author(s): ジョンワイズナー)

ニュートンプレス, Aug 23, 2024 (ISBN: 4315528447)
衛生薬学(改訂第2版): 基礎・予防・臨床

今井浩孝, 小椋康光 (Role: Joint editor)

南江堂, Sep 7, 2018 (ISBN: 452440354X)
Metallomics : recent analytical techniques and applications

Ogra, Yasumitsu, Hirata, Takafumi

Springer, 2017 (ISBN: 9784431564614)
衛生薬学: 基礎・予防・臨床

今井浩孝, 小椋康光 (Role: Joint editor)

南江堂, May 11, 2016 (ISBN: 4524403175)

Professional Memberships

Works

Speciation of Selenium in Biological and Food Samples

Research Projects

Establishment of necrochemistry and its application to legal medicine, forensic toxicology and public health

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Pioneering), Japan Society for the Promotion of Science, Jun, 2024 - Mar, 2027
Modification of detoxification of environmental toxicants by gut micro flora

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2024 - Mar, 2027
Exploration of metabolomics associated with disaster-related death: Analysis of metabolome with hypothermia

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2022 - Mar, 2024
Toxicological significance of metal biogenic nanoparticles

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Integrated Biometal Science: Research to Explore Dynamics of Metals in Cellular System

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2024
Development of advanced speciation for the matabolism of biometals

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2024
Research on the development and application of metallomics methods in the field of environmental medicine

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Yokoyama Kazuhito
Molecular mechanisms underlying the formation of bioorganometallic bond for metal toxicology

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Ogra Yasumitsu
Mechanism underlying the generation of reactive cyanogen species

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

OGRA Yasumitsu
Synthesis and biological evaluation of selenoneine, naturally occurring selenium containing compound

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Suzuki Noriyuki
tissue distribution and toxic mechanism of indium nano particles

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Tanaka Akiyo
Speciation and toxicological study of antimony in the environmental water in eastern and mid-southern China

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Ogra Yasumitsu
Elucidation of the metabolism and toxicity mechanism of arsenolipids by analytical chemistry techniques

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Oct, 2015 - Mar, 2018

Kobayashi Yayoi
Verification of the structure of selenophosphate

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Ogra Yasumitsu
Metallome analysis with cellular differentiation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Ogra Yasumitsu
Development of novel on-site analysis of urinary selenometabolites

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

OGRA Yasumitsu, ANAN Yasumi, TOKUMOTO Maki
Organotin-induced GluR2 decrease and its in vivo neuronal effects

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

KOTAKE Yaichiro, OHTA Shigeru, OGRA Yasumitsu
Elucidation of Selenium Metabolism in mammalian cells by speciation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

OGRA Yasumitsu, ANAN Yasumi, KOIZUMI Shinji
Tissue indium distribution after intratracheal instillation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

TANAKA Akiyo, HIRATA Miyuki, OGURA Yasumitu, KOGA Kazunori, YONEMOTO Kouji
Chemical speciation of blood selenium in a population with high intake of mercury

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

WATANABE Chiho, YASUTAKE Akira, OGURA Yasumitsu

Industrial Property Rights

特許第5798345号 TAFIaタンパク質に対して阻害活性を有する化合物

石井秀美, 山本恵子, 小椋康光, 吉本暢子, 杉本勝良, 佐々木知幸
特許第5660760号テルルを含む土壌等からテルルを回収する方法

小椋康光, 寺田麻里
特許第5583401号セレン含有化合物並びにこれを含有する植物及び栄養剤

小椋康光, 岩下雄二, 北口隆, 鈴木紀行, 鈴木和夫
特許第5322211号抗酸化剤

恵美伸男, 木戸智史, 小椋康光
特開2012-188396 TAFIaタンパク質に対して阻害活性を有する化合物

石井秀美, 山本恵子, 小椋康光, 吉本暢子, 杉本勝良, 佐々木知幸
特開2010-162453 テルルを含む土壌等からテルルを回収する方法

小椋康光, 寺田麻里
特許第4491607号全量導入型ネブライザー対応シースガス導入型スプレーチャンバー

小椋康光, 宮山貴光, 鈴木和夫
特開2010-083827 抗酸化剤

恵美伸男, 木戸智史, 小椋康光
WO2008-126756 セレン含有化合物並びにこれを含有する植物及び栄養剤

小椋康光, 岩下雄二, 北口隆, 鈴木紀行, 鈴木和夫
特開2006-242769 全量導入型ネブライザー対応シースガス導入型スプレーチャンバー

小椋康光, 宮山貴光, 鈴木和夫

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