HIGAI Koji

J-GLOBAL         Last updated: Sep 12, 2018 at 10:54
 
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Name
HIGAI Koji
Affiliation
Toho University
Section
Faculty of Pharmaceutical Sciences
Job title
Research assistant
Degree
(BLANK)

Research Areas

 
 

Education

 
 
 - 
1997
Graduate School, Division of Pharmaceutical Sciences, Toho University
 

Published Papers

 
Globo-A binds to the recombinant natural cytotoxicity receptor NKp44
Ito K., Shiraishi R., Higai K.
Biol. Pharm. Bull.   9(1) 1480-1484   2018   [Refereed]
Transcriptional Regulation of the Natural Cytotoxicity Receptor NKp44 Gene in Human NK cell Leukemia.
Ito K., Kawana M.,Iwata T., Higai K.
J of Glycomics Lipidomics   7(1) 0-0   2018   [Refereed]
Sorafenib Decreases Dihydropyrimidine Dehydrogenase Gene Expression in Hepatocellular Carcinoma HepG2 Cells
Higai K., Otsuka N., Tanaka Y., Matsumoto K., Matsui M., Yanai K., Wakui N., Nagai H
Austin J Pharmacol Ther.   6(1) 1102-1102   2018   [Refereed]
Quantitative measurements of sorafenib in patients with advanced hepatocellular carcinoma.
Kobayashi K., Higai K., Matsuo K., Bannai Y.,, Horie H., Otakara Y., Li W., Koike K., Yanagino S., Watanabe K., Yoshio T., Wakui N., Nagai H.
International Journal of Research Studies in Medical and Health Sciences   3(2) 14-19   2018   [Refereed]
Li W., Zhang J. Sasaki T. Nagata K., Higai K., Feng F., Wang J., Cheng M., Koike K.:
Bioorganic & Medicinal Chemistry Letters   28(7) 1194-1197   2018   [Refereed]
Pharmacological identification of β-adrenoceptor subtypes mediating  isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle
Chino D., Sone T., Yamazaki K., Tsuruoka Y., Yamagishi R., Shiina S., Obara K., Yamaki F., Higai K., Tanaka Y.
J. Smooth Muscle Res.   54(0) 13-27   2018   [Refereed]
Isolation, Structural Elucidation, and Liquid Chromatography?Mass Spectrometry Analysis of Steroidal Glycosides from Polygonatum odoratum
Liu Q., Li W., Nagata K., Fu H., Okada S., Tanabe I., Kobori Y., Higai K., Norie W., Sasaki T., Asada Y., Zhao H., Bai H., Koike K.
J. Agric. Food Chem.   66(2) 521-531   2018   [Refereed]
Sato N, Li W, Tsubaki M, Higai K, Takemoto M, Sasaki T, Onoda T, Suzuki T, Koike K
Journal of Functional Foods   35(0) 159-165   2017   [Refereed]
Onoda T, Li W, Sasaki T, Miyake M, Higai K, Koike K
Journal of Ethnopharmacology   186(0) 84-90   2016   [Refereed]
Sorafenib and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombus
Nagai H, Mukozu T, Ogino YU, Matsui D, Matsui T, Wakui N, Momiyama K, Igarashi Y, Sumino Y, Higai K
Anticancer Res.   35(4) 2269-2277   2015   [Refereed]
Sasaki T., Li W., Higai K., Koike K
Bioorg Med Chem Lett   25(9) 1979-1981   2015   [Refereed]
Sasaki T., Li W., Higai K., Quang T., Kim Y.,2, Koike K.
Planta Medica   80(7) 557-560   2014   [Refereed]
Onoda T., Li W., Higai K, Koike K
BMC Complement Altern Med   20(14) 64-64   2014   [Refereed]
Protein tyrosine phosphatase 1B inhibitory activities of ursane- and lupane-type triterpenes from Sorbus pohuashanensis
Li D., Li W., Higai K, Koike K
J Nat Med.   0(0) 0-0   2013   [Refereed]
Li W., Li S., Higai K., Sasaki T., Asada Y., Ohshima S., Koike K.
Bioorg Med Chem Lett.   23(21) 5836-5839   2013   [Refereed]
Taniuchi F., Higai K., Tanaka T., Azuma Y.. Matsumoto K.
ScientificWorldJournal   105464(0) 0-0   2013   [Refereed]
Higai K., Matsumoto K.
Yakugaku Zasshi   132(6) 705-712   2012   [Refereed]
Ito K., Higai K., Shinoda C., Sakurai M., Yanai K., Azuma Y., Matsumoto K.
Biol. Pharm. Bull.   35(4) 1-7   2012   [Refereed]
NKG2D: Binding Properties for Glycan Ligands, and Mutagenesis Analysis.
Higai K., Matsumoto S.,Kimura M.,Imaizumi Y.,Yanai K., Azuma Y., Matsumoto K.
The Open Biotechnology Journal   5(0) 33-38   2011   [Refereed]
Azuma Y, Nakagawa H, Dote K, Higai K and Matsumoto K
Biol. Pharm. Bull.   34(12) 1828-1834   2011   [Refereed]
Higai K., Itoh A., Imaizumi Y., Suzuki C., Xin X., Azuma Y. and Matsumoto K.
The Open Biotechnology Journal   5(0) 14-20   2011   [Refereed]
Ito K, Higai K, Sakurai M, Shinoda C, Yanai K, Azuma Y, Matsumoto K
Biochemical and biophysical research communications   406(3) 377-382   2011   [Refereed]
Xin X, Higai K, Imaizumi Y, Suzuki C, Ito K, Itoh A, Matsumoto S, Azuma Y, Matsumoto K
Biological & pharmaceutical bulletin   34(4) 480-485   2011   [Refereed]
Higai K, Suzuki C, Imaizumi Y, Xin X, Azuma Y, Matsumoto K
Biological & pharmaceutical bulletin   34(1) 8-12   2011   [Refereed]
Imaizumi Y, Higai K, Suzuki C, Azuma Y, Matsumoto K
Biochemical and biophysical research communications   382(3) 604-608   2009   [Refereed]
Higai K, Imaizumi Y, Suzuki C, Azuma Y, Matsumoto K
Biochemical and biophysical research communications   386(4) 709-714   2009   [Refereed]
Higai K, Tsukada M, Moriya Y, Azuma Y, Matsumoto K
Biochimica et biophysica acta   1790(1) 8-15   2009   [Refereed]
Sato H, Azuma Y, Higai K, Matsumoto K
Biochimica et biophysica acta   1790(10) 1198-1205   2009   [Refereed]
Higai K, Satake M, Nishioka H, Azuma Y, Matsumoto K
Biochimica et biophysica acta   1780(2) 307-314   2008   [Refereed]
Taniguchi A., Higai K., Hasegawa Y., Utsumi K., Matsumoto K.
FEBS Lett   441(2) 191-194   1998   [Refereed]
Higai K, Miyazaki N, Azuma Y, Matsumoto K
Glycoconjugate journal   25(3) 225-235   2008   [Refereed]
Azuma Y, Kurusu Y, Sato H, Higai K, and Matsumoto K
Biol. Pharm. Bull.   30(4) 655-660   2007   [Refereed]
Azuma Y, Sato H, Higai K, and Matsumoto K
Biol. Pharm. Bull.   30(9) 1680-1684   2007   [Refereed]
Higai K, Sano R, Satake M, Azuma Y, and Matsumoto K
Biol. Pharm. Bull.   30(10) 1833-1837   2007   [Refereed]
Higai K, Ichikawa A, Matsumoto K
Biochim Biophys Acta.   1760(9) 1355-1363   2006   [Refereed]
Higai K, Ishihara S, and Matsumoto K
Biol. Pharm. Bull.   29(12) 2372-2377   2006   [Refereed]
Higai K, Miyazaki N, Azuma Y and Matsumoto K
FEBS lett.   580(26) 6069-6075   2006   [Refereed]
Higai K, Aoki Y, Matsumoto K
Biochim Biophys Acta.   1725(1) 128-135   2005   [Refereed]
Higai K, Shibukawa K, Muto S, Matsumoto K
Anal. Sci.   19(1) 85-92   2003   [Refereed]
Higai K, Azuma Y, Aoki Y, Matsumoto K
Clin Chim Acta   329(1) 117-125   2003   [Refereed]
Taniguchi A, Hasegawa Y, Higai K, Matsumoto K
Glycobiology   10(6) 623-628   2000   [Refereed]
Taniguchi A, Hasegawa Y, Higai K, Matsumoto K
Mol Cell Biol Res Commun   2(3) 197-201   1999   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2009 - 2010    Investigator(s): Koji HIGAI
Using recombinant extracellular lectin-like domains of KLRs (rKLRs) and NCRs (rNCRs) on NK cells, we evaluated their ligands specificity and binding affinities. Our data resulted that rKLRs and rNCRs can bind to sialyl Lewis X, GAGs and sulfated p...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2007 - 2008    Investigator(s): Koji HIGAI
初めに、sLeX合成関連糖転移酵素群のFUT VIの遺伝子発現制御機構を転写レベルで解析し、転写開始点およびHNF-4αがFUT VIの発現に重要であることを明らかにした。つぎに、sLeXの生体内免疫応答への関与を、NK細胞上のCD94およびNKG2Dに着目し、その糖鎖リガンドを明らかにした。本研究により、NK細胞上のCD94およびNKG2DがsLeX様の糖鎖を認識し、がん細胞の増殖を抑制することが考えられた。
Effects of Glycan on NK activity
Project Year: 2003 - 2005
Effect of Glycated albumin
Project Year: 2002 - 2005