SHIMOSAWA Tatsuo

J-GLOBAL         Last updated: Mar 4, 2019 at 15:25
 
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Name
SHIMOSAWA Tatsuo
Affiliation
International University of Health and Welfare
Section
Faculty of Medicine University Hospital, Clinical Laboratory Center, Department of Clinical Laboratory Meidicine
Job title
Lecturer
Degree
(BLANK)(The University of Tokyo)
Twitter ID
下澤達雄@shimocla

Research Areas

 
 

Academic & Professional Experience

 
Apr 2017
 - 
Today
Professor and Chair, Dept of Clinical Laboratory, School of Medicine, International University of Health and Welfare
 
1997
 - 
2001
University of Tokyo, Branched Hospital, Research Assistant
 
2001
   
 
University of Tokyo, Dept. Nephrd. Endocrinol. Research Assistant
 

Education

 
 
 - 
1997
Graduate School, Division of Medical Sciences, The University of Tokyo
 
 
 - 
1988
Faculty of Medicine, University of Tsukuba
 

Published Papers

 
Nishimoto M, Ohtsu H, Marumo T, Kawarazaki W, Ayuzawa N, Ueda K, Hirohama D, Kawakami-Mori F, Shibata S, Nagase M, Isshiki M, Oba S, Shimosawa T, Fujita T
Hypertension research : official journal of the Japanese Society of Hypertension      Jan 2019   [Refereed]
Tokuhara Y, Shukuya K, Tanaka M, Sogabe K, Ejima Y, Hosokawa S, Ohsaki H, Morinishi T, Hirakawa E, Yatomi Y, Shimosawa T
Scientific reports   8(1) 11364   Jul 2018   [Refereed]
Kawakami-Mori F, Nishimoto M, Reheman L, Kawarazaki W, Ayuzawa N, Ueda K, Hirohama D, Kohno D, Oba S, Shimosawa T, Marumo T, Fujita T
JCI insight   3(21)    Nov 2018   [Refereed]
Oba S, Ayuzawa N, Nishimoto M, Kawarazaki W, Ueda K, Hirohama D, Kawakami-Mori F, Shimosawa T, Marumo T, Fujita T
Scientific reports   8(1) 16338   Nov 2018   [Refereed]
Inagaki S, Maeda S, Narita M, Nakamura T, Shimosawa T, Murata T, Ohya Y
The Journal of allergy and clinical immunology      Jul 2018   [Refereed]
Yasukawa K, Shimosawa T, Okubo S, Yatomi Y
Annals of clinical biochemistry   55(1) 121-127   Jan 2018   [Refereed]
Hirohama D, Ayuzawa N, Ueda K, Nishimoto M, Kawarazaki W, Watanabe A, Shimosawa T, Marumo T, Shibata S, Fujita T
Journal of the American Society of Nephrology : JASN   29(1) 57-68   Jan 2018   [Refereed]
HISASUE Takashi, SHUKUYA Kenichi, TANAKA Masami, MOURI Mariko, SONE Shinji, SHIMOSAWA Tatsuo, IKEDA Hitoshi, YATOMI Yutaka
Japanese Journal of Medical Technology   67(4) 605-610   2018
<p>Characteristic crystals were identified in urine samples from chronic hepatitis C patients during triple-drug therapy with telaprevir, peginterferon and ribavirin. These crystals are insoluble in acid or alkaline solutions, as well as organic s...
Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, Yatomi Y, Murata T
Scientific reports   7(1) 17687   Dec 2017   [Refereed]
Shukuya K, Ogura S, Tokuhara Y, Okubo S, Yatomi Y, Tozuka M, Shimosawa T
Clinica chimica acta; international journal of clinical chemistry   472 104   Sep 2017   [Refereed]
Ueda K, Nishimoto M, Hirohama D, Ayuzawa N, Kawarazaki W, Watanabe A, Shimosawa T, Loffing J, Zhang MZ, Marumo T, Fujita T
Hypertension (Dallas, Tex. : 1979)   70(1) 111-118   Jul 2017   [Refereed]
Xu N, Hirohama D, Ishizawa K, Chang WX, Shimosawa T, Fujita T, Uchida S, Shibata S
Hypertension (Dallas, Tex. : 1979)   69(5) 855-862   May 2017   [Refereed]
Watanabe S, Ogasawara T, Tamura Y, Saito T, Ikeda T, Suzuki N, Shimosawa T, Shibata S, Chung UI, Nangaku M, Uchida S
PloS one   12(3) e0168638   2017   [Refereed]
Wang CH, Wang Z, Liang LJ, Wang XT, Ma XL, Liu BB, He JQ, Shimosawa T, Xu QY
Nephron   136(4) 328-338   2017   [Refereed]
Shukuya K, Ogura S, Tokuhara Y, Okubo S, Yatomi Y, Tozuka M, Shimosawa T
Clinica chimica acta; international journal of clinical chemistry   457 142-149   Jun 2016   [Refereed]
Isokawa M, Shimosawa T, Funatsu T, Tsunoda M
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences   1019 59-65   Apr 2016   [Refereed]
HISASUE Takashi, SHUKUYA Kenichi, TANAKA Masami, JONA Masahiro, OKUBO Shigeo, MASUDA Akiko, SHIMOSAWA Tatsuo, YATOMI Yutaka
Japanese Journal of Medical Technology   65(6) 685-689   2016
<p>Multiple myeloma is a cancer of plasma cells, which presents with symptoms such as anemia, osteolytic bone lesions, and renal dysfunction. Central nervous system (CNS) involvement in multiple myeloma is very uncommon. We report a case of CNS in...
Nara A, Nagai H, Shintani-Ishida K, Ogura S, Shimosawa T, Kuwahira I, Shirai M, Yoshida K
American journal of respiratory cell and molecular biology   53(2) 184-192   Aug 2015   [Refereed]
Uetake Y, Ikeda H, Irie R, Tejima K, Matsui H, Ogura S, Wang H, Mu S, Hirohama D, Ando K, Sawamura T, Yatomi Y, Fujita T, Shimosawa T
Lipids in health and disease   14 6   Feb 2015   [Refereed]
MORI Mariko, TANAKA Masami, KAGEYAMA Yuko, SHUKUYA Kenichi, OKUBO Shigeo, FUJISHIRO Midori, SHIMOSAWA Tatsuo, YATOMI Yutaka
Japanese Journal of Medical Technology   64(3) 324-329   2015
The methods mainly used for diagnosing alkaptonuria require keeping urine at room temperature or alkalizing urine using 10% sodium hydroxide and observing the color change. However, the change in urine color is ambiguous and it takes a long time t...
Hong W, Tatsuo S, Shou-Dong W, Qian Z, Jian-Feng H, Jue W, Chen J, Hai-Yan Q, Yue-Jin Y
PloS one   10(6) e0128978   2015   [Refereed]
Nagai H, Kuwahira I, Schwenke DO, Tsuchimochi H, Nara A, Ogura S, Sonobe T, Inagaki T, Fujii Y, Yamaguchi R, Wingenfeld L, Umetani K, Shimosawa T, Yoshida K, Uemura K, Pearson JT, Shirai M
PloS one   10(7) e0131923   2015   [Refereed]
Jimbo R, Kawakami-Mori F, Mu S, Hirohama D, Majtan B, Shimizu Y, Yatomi Y, Fukumoto S, Fujita T, Shimosawa T
Kidney international   85(5) 1103-1111   May 2014   [Refereed]
Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ishimitsu T, Ito M, Ito S, Itoh H, Iwao H, Kai H, Kario K, Kashihara N, Kawano Y, Kim-Mitsuyama S, Kimura G, Kohara K, Komuro I, Kumagai H, Matsuura H, Miura K, Morishita R, Naruse M, Node K, Ohya Y, Rakugi H, Saito I, Saitoh S, Shimada K, Shimosawa T, Suzuki H, Tamura K, Tanahashi N, Tsuchihashi T, Uchiyama M, Ueda S, Umemura S, Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension   37(4) 253-390   Apr 2014   [Refereed]
Kono R, Kanozawa K, Shimosawa T, Tayama Y, Matsuda A, Hasegawa H, Mitarai T
Clinical and experimental nephrology   18(1) 124-129   Feb 2014   [Refereed]
Tokuhara Y, Shukuya K, Tanaka M, Mouri M, Ohkawa R, Fujishiro M, Takahashi T, Okubo S, Yokota H, Kurano M, Ikeda H, Yamaguchi S, Inagaki S, Ishige-Wada M, Usui H, Yatomi Y, Shimosawa T
PloS one   9(1) e86606   2014   [Refereed]
Ando K, Nitta K, Rakugi H, Nishizawa Y, Yokoyama H, Nakanishi T, Kashihara N, Tomita K, Nangaku M, Takahashi K, Isshiki M, Shimosawa T, Fujita T
International journal of medical sciences   11(9) 897-904   2014   [Refereed]
Mitome-Mishima Y, Miyamoto N, Tanaka R, Shimosawa T, Oishi H, Arai H, Hattori N, Urabe T
BioMed research international   2014 861632   2014   [Refereed]
Nagai H, Kuwahira I, Schwenke DO, Tsuchimochi H, Nara A, Inagaki T, Ogura S, Fujii Y, Umetani K, Shimosawa T, Yoshida K, Pearson JT, Uemura K, Shirai M
PloS one   9(10) e110693   2014   [Refereed]
Masuzawa T, Saito I, Yamada T, Onishi M, Yamaguchi H, Suzuki Y, Oonuki K, Kato N, Ogawa S, Takakuwa Y, Koh AT, Chua DH, Mori Y, Shimosawa T, Okano K
Sensors (Basel, Switzerland)   13(10) 13744-13778   Oct 2013   [Refereed]
Shimosawa T
Hypertension research : official journal of the Japanese Society of Hypertension   36(8) 657-660   Aug 2013   [Refereed]
Nikitenko LL, Shimosawa T, Henderson S, Mäkinen T, Shimosawa H, Qureshi U, Pedley RB, Rees MC, Fujita T, Boshoff C
The Journal of investigative dermatology   133(7) 1768-1776   Jul 2013   [Refereed]
Ogura S, Shimosawa T, Mu S, Sonobe T, Kawakami-Mori F, Wang H, Uetake Y, Yoshida K, Yatomi Y, Shirai M, Fujita T
American journal of physiology. Heart and circulatory physiology   305(2) H155-62   Jul 2013   [Refereed]
Saito T, Hasegawa Y, Ishigaki Y, Yamada T, Gao J, Imai J, Uno K, Kaneko K, Ogihara T, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H
Cardiovascular research   97(1) 106-114   Jan 2013   [Refereed]
SUZUKI Masashi, NUKUI Yoko, MORIYA Kyoji, OKUGAWA Shu, UCHIDA Miho, MAHIRA Tamami, SHIMOSAWA Tatsuo, ISHII Takeshi, DOI Kent, SUZUKI Rie, TATSUNO Keita
Japanese Journal of Environmental Infections   28(3) 173-177   2013
&nbsp;&nbsp;Multidrug-resistant Pseudomonas aeruginosa, MDRP, is one of the most important gram-negative bacteria in hospital infection control. P. aeruginosa is occasionally isolated from urine samples and colonize in moist hospital...
Hayashi M, Tojo A, Shimosawa T, Fujita T
Journal of diabetes research   2013 134395   2013   [Refereed]
Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, Satoh Y, Shimosawa T, Shinozaki K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Yokota H, Koyama T, Ishimaru K, Okamoto Y, Takuwa Y, Koike K, Yatomi Y
Hepatology (Baltimore, Md.)   56(4) 1427-1438   Oct 2012   [Refereed]
Saito R, Shimosawa T, Ogihara T, Maruyama N, Fujita T, Okamura N, Nakahara K
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica   120(9) 706-711   Sep 2012   [Refereed]
Hasegawa Y, Saito T, Ogihara T, Ishigaki Y, Yamada T, Imai J, Uno K, Gao J, Kaneko K, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H
Circulation   125(9) 1122-1133   Mar 2012   [Refereed]
Kawakami-Mori F, Shimosawa T, Mu S, Wang H, Ogura S, Yatomi Y, Fujita T
American journal of physiology. Endocrinology and metabolism   302(4) E425-32   Feb 2012   [Refereed]
Ando K, Haneda M, Ito S, Kashihara N, Node K, Nangaku M, Shimosawa T, Kishimoto J, Fujita T
Cardiovascular drugs and therapy   25(4) 341-347   Aug 2011   [Refereed]
Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayuzawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T
The Journal of clinical investigation   121(8) 3233-3243   Aug 2011   [Refereed]
Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T
Nature medicine   17(5) 573-580   May 2011   [Refereed]
Yamamoto C, Fukuda N, Jumabay M, Saito K, Matsumoto T, Ueno T, Soma M, Matsumoto K, Shimosawa T
Hypertension research : official journal of the Japanese Society of Hypertension   34(3) 348-353   Mar 2011   [Refereed]
Unuma K, Shintani-Ishida K, Yahagi N, Tsushima K, Shimosawa T, Ueyama T, Yoshida K
Circulation journal : official journal of the Japanese Circulation Society   74(12) 2693-2701   Nov 2010   [Refereed]
TANAKA Masami, SHUKUYA Ken-ichi, YOKOTA Hiromitsu, SHIMOSAWA Tatsuo, YATOMI Yutaka
医学検査 : 日本臨床衛生検査技師会誌 = The Japanese journal of medical technology   59(6) 811-814   Jun 2010
Unuma K, Shintani-Ishida K, Tsushima K, Shimosawa T, Ueyama T, Kuwahara M, Yoshida K
Circulation journal : official journal of the Japanese Circulation Society   74(6) 1087-1095   Jun 2010   [Refereed]
Miyamoto N, Tanaka R, Shimosawa T, Yatomi Y, Fujita T, Hattori N, Urabe T
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism   29(11) 1769-1779   Nov 2009   [Refereed]
Hirahashi J, Hishikawa K, Kaname S, Tsuboi N, Wang Y, Simon DI, Stavrakis G, Shimosawa T, Xiao L, Nagahama Y, Suzuki K, Fujita T, Mayadas TN
Circulation   120(13) 1255-1265   Sep 2009   [Refereed]
Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y
Journal of lipid research   50(3) 556-564   Mar 2009   [Refereed]
Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J
Cell metabolism   9(2) 191-202   Feb 2009   [Refereed]
Shimosawa T
Hypertension research : official journal of the Japanese Society of Hypertension   31(9) 1679-1680   Sep 2008   [Refereed]
TANAKA Masami, SHUKUYA Kenichi, KANNO Nobuko, YOKOTA Hiromitsu, SHIMOSAWA Tatsuo, KIKUCHI Yoshinao, FUKUSHIMA Noriyoshi, YATOMI Yutaka
医学検査 : 日本臨床衛生検査技師会誌 = The Japanese journal of medical technology   57(8) 1063-1065   Aug 2008
Matsui H, Ando K, Kawarazaki H, Nagae A, Fujita M, Shimosawa T, Nagase M, Fujita T
Hypertension (Dallas, Tex. : 1979)   52(2) 287-294   Aug 2008   [Refereed]
TANAKA Masami, SHUKUYA Kenichi, MISHIMA Yuuko, KANNO Nobuko, YOKOTA Hiromitsu, SHIMOSAWA Tatsuo, YATOMI Yutaka
医学検査 : 日本臨床衛生検査技師会誌 = The Japanese journal of medical technology   57(7) 979-981   Jul 2008
Wang H, Shimosawa T, Matsui H, Kaneko T, Ogura S, Uetake Y, Takenaka K, Yatomi Y, Fujita T
Journal of hypertension   26(7) 1453-1462   Jul 2008   [Refereed]
Marumo T, Hishikawa K, Matsuzaki Y, Imai N, Takase O, Shimosawa T, Okano H, Fujita T
European journal of pharmacology   573(1-3) 216-220   Nov 2007   [Refereed]
Hirano Y, Tsunoda M, Shimosawa T, Fujita T, Funatsu T
Biological & pharmaceutical bulletin   30(11) 2178-2180   Nov 2007   [Refereed]
Shimosawa T, Gohchi K, Yatomi Y, Fujita T
Hypertension research : official journal of the Japanese Society of Hypertension   30(9) 831-837   Sep 2007   [Refereed]
Yamauchi Y, Fujikura T, Shimosawa T
Allergology international : official journal of the Japanese Society of Allergology   56(2) 171-177   Jun 2007   [Refereed]
Liu J, Shimosawa T, Matsui H, Meng F, Supowit SC, DiPette DJ, Ando K, Fujita T
American journal of physiology. Heart and circulatory physiology   292(4) H1714-21   Apr 2007   [Refereed]
Hirano Y, Tsunoda M, Shimosawa T, Matsui H, Fujita T, Funatsu T
Hypertension research : official journal of the Japanese Society of Hypertension   30(3) 269-278   Mar 2007   [Refereed]
Moriya J, Takimoto Y, Yoshiuchi K, Shimosawa T, Akabayashi A
Psychoneuroendocrinology   31(9) 1057-1061   Oct 2006   [Refereed]
Shimosawa T
Hypertension research : official journal of the Japanese Society of Hypertension   29(9) 643-644   Sep 2006   [Refereed]
Matsui H, Shimosawa T, Uetake Y, Wang H, Ogura S, Kaneko T, Liu J, Ando K, Fujita T
Hypertension (Dallas, Tex. : 1979)   48(2) 225-231   Aug 2006   [Refereed]
TANAKA Masami, SHUKUYA Kenichi, TOTSUKA Minoru, SHIMOSAWA Tatsuo, YATOMI Yutaka
医学検査 : 日本臨床衛生検査技師会誌 = The Japanese journal of medical technology   55(7) 846-849   Jul 2006
Kushiyama A, Shojima N, Ogihara T, Inukai K, Sakoda H, Fujishiro M, Fukushima Y, Anai M, Ono H, Horike N, Viana AY, Uchijima Y, Nishiyama K, Shimosawa T, Fujita T, Katagiri H, Oka Y, Kurihara H, Asano T
The Journal of biological chemistry   280(51) 42016-42025   Dec 2005   [Refereed]
Ando K, Takahashi K, Shibata S, Matsui H, Fujita M, Shibagaki Y, Shimosawa T, Isshiki M, Fujita T
Hypertension research : official journal of the Japanese Society of Hypertension   27(12) 985-992   Dec 2004   [Refereed]
ANDO Katsuyuki, SHIMOSAWA Tatsuo, TOMINAGA Youko, FUJITA Toshiro, KOUGAME Kouji
日本循環器管理研究協議会雑誌 = Journal of the Japanese Association for Cerebro-cardiovascular Disease Control   32(2) 109-114   Oct 1997
Nakao Mutsuhiro, Nomura Shinobu, Kuboki Tomifusa, Suematsu Hiroyuki, Shimozawa Tatsuo, Fujita Toshirou
Japanese journal of behavior therapy   21(2) 71-78   Sep 1995
The purpose of this study is to discuss the application of the blood presure (BP) biofeedback system to the treatment of white-coat hypertension. Subjects of this study were 10 outpatients with hypertension. Five patients with more than 25mmHg of ...
Shimosawa Tatsuo, Kuwajima Iwao, Suzuki Yasuko, Kanemaru Akiko, Kuramoto Kizuku
Jpn. j. geriat   29(9) 661-666   1992
To clarify the mechanism of postprandial hypotension in the elderly, blood pressure and humoral factors were measured before and after meal, water, and glucose ingestion in 20 healthy elderly. The elderly patients were divided into 10 normotensive...
Shimosawa Tatsuo, Kuwajima Iwao, Suzuki Yasuko, Hoshino Satoshi, Kanemaru Akiko, Kuramoto Kizuku
HEART   24(5) 541-546   1992
老年者高血圧性心胞大(LVH)例における血圧日内変動の特徴を知る目的で,降圧剤を服用していない本態性高血圧患者38例を心肥大群(HT1群)15例(76.7±5.1歳)と肥大のない群(HT2群)23例(72.8±6.1歳)に分け,さらに正常血圧者群(NT群)11例(73.2±5.8歳)を対象とし,非観血的に24時間血圧を測定し,収縮期血圧(SBP)について24時間,日中(5:30-21:00),夜間(21:30-5:00)の平均を求めた.また等尺運動負荷前後の血圧変化についても検討した.LV...
Shimosawa Tatsuo, Ohyama Toshiroh, Kuramoto Kizuku, Esaki Yukiyoshi, Kuwalima Iwao, Ohkawa Shinichro, Hirose Shouko, Kanemaru Akiko, Hoshino Satoru, Suzuki Yasuko, Chida Kouli, Sakai Makoto
HEART   23(6) 679-684   1991
症例は77歳,女性.昭和59年,紅斑,四肢筋力低下,微熱あり,筋電図,CPK高値,皮膚,筋肉生検から皮慮筋炎と診断された.プレドニン,アザチオプリンなどにて症状は安定.平成元年7月7日,体重減少,動悸,炎症所見の進展,CPK上昇のため当センター入院.入院時心電図は正常洞調律.7月25日よりII度房室ブロック.その後,急速に完全房室ブロックへ移行したため,8月4日,永久ペースメーカー植え込み術施行.8月15日,呼吸停止,ペーシング不全状態で発見されたが,蘇生術によりペーシングは良好となった....

Misc

 
Shimosawa T
Hypertension research : official journal of the Japanese Society of Hypertension   41(10) 783   Oct 2018   [Refereed]
下澤 達雄
日本臨床 = Japanese journal of clinical medicine   76(8) 1409-1412   Aug 2018
【高血圧の最新診断・治療-ガイドラインから個別予見医療へ-】 新規バイオマーカー 高血圧治療における検査診断の意義 バイオマーカー
下澤 達雄
日本臨床   76(8) 1409-1412   Aug 2018
【高血圧:エビデンスと推奨-日常診療への提言】 高血圧の成因 食塩
下澤 達雄
腎と透析   85(2) 126-130   Aug 2018
【老年医学(上)-基礎・臨床研究の最新動向-】 高齢患者へのアプローチ 老年医学的評価法 高齢者の検査値の評価
下澤 達雄
日本臨床   76(増刊5 老年医学(上)) 317-321   Jun 2018
血圧計を使い分ける
下澤 達雄
日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   7回 154-154   May 2018
腎臓特異的DNAメチル化を尿中マーカーとした糖尿病性腎症の尿細管障害診断法
丸茂 丈史, 下澤 達雄, 河原崎 和歌子, 西本 光宏, 鮎澤 信宏, 広浜 大五郎, 上田 浩平, 佐藤 敦久, 渥美 義仁, 星野 純一, 乳原 善文, 藤田 敏郎
日本腎臓学会誌   60(3) 331-331   Apr 2018
保存期腎不全における酸化型・還元型アルブミンの検討
仲谷 慎也, 森 克仁, 仲谷 あゆ美, 都井 律和, 山田 真介, 津田 昌宏, 下澤 達雄, 石村 栄治, 安川 恵子, 矢冨 裕, 稲葉 雅章
日本腎臓学会誌   60(3) 423-423   Apr 2018
酸化型アルブミンの基準範囲の設定 糖尿病関連疾患における臨床的有用性の検討のために
安川 恵子, 野尻 卓宏, 吉川 直之, 増戸 梨恵, 甲斐 三与子, 大池 裕美子, 山崎 力, 下澤 達雄, 池田 均
糖尿病   61(Suppl.1) S-273   Apr 2018
腎pendrinの発現機構と血圧調節における役割の解明
広浜 大五郎, 鮎澤 信宏, 上田 浩平, 西本 光宏, 河原崎 和歌子, 渡邉 篤史, 下澤 達雄, 丸茂 丈史, 柴田 茂, 藤田 敏郎
日本内分泌学会雑誌   93(4) 1377-1377   Dec 2017
LC/MS解析による血中CRP複合体についての検討
小倉 彩世子, 下澤 達雄, 中山 智祥
日本内分泌学会雑誌   93(4) 1389-1389   Dec 2017
丸茂 丈史, 下澤 達雄
医学のあゆみ   255(6) 691-696   Nov 2015
Shimosawa T
Nihon rinsho. Japanese journal of clinical medicine   73(11) 1833-1835   Nov 2015   [Refereed]
[Hypertension: The Points of Management of Hypertension for All Physicians--Based on the JSH 2014 Hypertension Guidelines--.Topics: II. Primary examinations for hypertensives].
Shimosawa T
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   104(2) 211-217   Feb 2015   [Refereed]
SHIMOSAWA Tatsuo
Annual Meeting of the Japanese Society of Toxicology   42(0) S19-4   2015
死因の第一位をしめる高血圧の発症要因には遺伝的背景のみならず環境要因が重要であることが知られており、これらが複雑に絡み合うモザイクモデルが提唱されて久しい。高血圧症のうちとくに塩分摂取により血圧が上昇する食塩感受性高血圧症は狭心症、心筋梗塞、脳卒中などを発症しやすく生命予後が不良である。古くから交感神経活動や胎生期の母体内のストレスが成人後の食塩感受性高血圧に関与することが動物実験や疫学調査から知られていた。そこで、我々はカテコラミン毒性やストレス応答ホルモンによる遺伝子変化と食塩感受性高...
TANAKA Masami, SHUKUYA Ken-ichi, MORITA Yoshifumi, HISASUE Naoko, KAGEYAMA Yuko, OKUBO Shigeo, SHIMOSAWA Tatsuo, YATOMI Yutaka
Japanese Journal of Medical Technology   64(6) 749-754   2015
We evaluated the clinical usefulness of XN-550, an automated hematology analyzer (Sysmex, Japan), for the determination of cell count in cerebrospinal fluid samples. Reproducibility, linearity, sensitivity and correlation of findings with those of...
下澤 達雄
循環器内科   76(4) 362-365   Oct 2014
Ogura S, Shimosawa T
Current hypertension reports   16(8) 452   Aug 2014   [Refereed]
Shimosawa T
Rinsho byori. The Japanese journal of clinical pathology   61(3) 263-270   Mar 2013   [Refereed]
Jimbo R, Shimosawa T
International journal of hypertension   2014 381082   2014   [Refereed]
下澤 達雄
生物試料分析 = Journal of analytical bio-science   35(3) 201-208   2012
Uetake Y, Shimosawa T
Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 1(0) 197-200   Jan 2011   [Refereed]
下澤 達雄
医学のあゆみ   243(7) 587-590   Nov 2012
小倉 彩世子, 下澤 達雄
内分泌・糖尿病・代謝内科   35(5) 432-436   Nov 2012
Shimosawa T
Nihon Jinzo Gakkai shi   51(4) 438-441   May 2009   [Refereed]
Shimosawa T, Mu S, Shibata S, Fujita T
Current hypertension reports   14(5) 468-472   Oct 2012   [Refereed]
Shimosawa T, Kaneko T, Uetake Y, Miyamoto Y, Matsui H, Wang H, Mu S, Saito R, Ogura S, Yatomi Y, Fujita T
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   45(3) 287-290   May 2008   [Refereed]
下澤 達雄, 藤田 敏郎
医学のあゆみ   241(13) 961-965   Jun 2012
SHIMOZAWA Tatsuo, MU Shengyu, FUJITA Toshiro
KAGAKU TO SEIBUTSU   50(4) 250-254   Apr 2012
塩分摂取により高血圧が発症するメカニズムには遺伝的背景,ホルモン環境,腎機能などが関与することが知られていたが,最近,&beta;2アドレナリン受容体刺激を介してヒストンがアセチル化されることが明らかになり,その結果グルココルチコイド受容体の作用が亢進し,腎臓でナトリウムを再吸収するチャネル (NCC) の発現が亢進することがそのメカニズムの一つであることが示された.得られた成果がエピジェネティクス制御を介した新たな治療法の開発につながることが期待される.
下澤 達雄, 穆 勝宇, 藤田 敏郎
内分泌・糖尿病・代謝内科   34(4) 347-352   Apr 2012
Shimosawa T
Circulation journal : official journal of the Japanese Circulation Society   75(2) 270-271   2011   [Refereed]
上竹 勇三郎, 下澤 達雄
医学のあゆみ   233(3) 201-204   Apr 2010
Shimosawa Tatsuo, Yatomi Yutaka, Fujita Toshiro, Kaneko Tomoyo, Uetake Yusaburo, Miyamoto Yusei, Matsui Hiromitsu, Wang Hong, Mu Shengyu, Saito Rika, Ogura Sayoko
Nippon Ronen Igakkai Zasshi   45(3) 287-290   2008
Shimosawa T, Fujita T
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   41(2) 141-149   Mar 2004   [Refereed]
王 紅, 下澤 達雄
医学のあゆみ   228(5) 374-377   Jan 2009
SHIMOSAWA Tatsuo
Journal of Tokyo Women's Medical College   76(7) 260-261   Jul 2006
[Adrenomedullin gene].
Shimosawa T
Nihon rinsho. Japanese journal of clinical medicine   64 Suppl 5 399-402   Jul 2006   [Refereed]
[Ion channel and blood pressure].
Shimosawa T
Nihon rinsho. Japanese journal of clinical medicine   64 Suppl 5 203-207   Jul 2006   [Refereed]
[Antiatherosclerotic hopes of calcium channel blockers].
Uetake Y, Shimosawa T
Clinical calcium   15(10) 1689-1694   Oct 2005   [Refereed]
[Increasing oxidative stress in aging].
Shimosawa T
Nihon rinsho. Japanese journal of clinical medicine   63(6) 994-999   Jun 2005   [Refereed]
UETAKE Yuzaburo, SHIMOSAWA Tatsuo
ホルモンと臨牀   53(3) 281-286   Mar 2005
[Renin-angiotensin system and oxidative stress].
Shimosawa T
Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 3 96-101   Mar 2005   [Refereed]
[Magnesium and N-type calcium channel].
Shimosawa T, Fujita T
Clinical calcium   15(2) 239-244   Feb 2005   [Refereed]
[Translational research on adrenomedullin].
Shimosawa T, Fujita T
Nihon rinsho. Japanese journal of clinical medicine   62 Suppl 9 290-295   Sep 2004   [Refereed]
[Adrenomedullin-knockout mouse].
Shimosawa T
Nihon rinsho. Japanese journal of clinical medicine   62 Suppl 9 207-210   Sep 2004   [Refereed]
Adrenomedullin in vascular diseases.
Ando K, Shimosawa T, Fujita T
Current hypertension reports   6(1) 55-59   Feb 2004   [Refereed]
Fujita Megumi, Shimosawa Tatsuo, Ando Katsuyuki, Fujita Toshiro, Kuwaki Tomoyuki
Proc Annu Meet PSJ   2004(0) S99-S99   2004
Central sympathetic activation is one of the mechanisms of salt-sensitive hypertension and reactive oxygen species (ROS) has been proposed to play a key role in it. We examined whether adrenomedullin (AM), an antioxidant peptide, might contribute ...
Shimosawa Tatsuo, Fujita Toshiro
Nippon Ronen Igakkai Zasshi   41(2) 141-149   2004
アドレノメデュリンは我が国で発見された降圧ペプチドであるが, 最近では抗酸化作用を含めた pleiotropic effect が注目されている, 各種基礎検討特にノックアウトマウスの解析から, アドレノメデュリンの臓器保護作用や生殖系への作用を有することが明らかとなった. さらにホモロジー検索から新たなペプチドが発見されている. SNP解析も行われており, 疾患との関連性が明らかにされることが期待される. さらに, 最近では臨床応用として体液量の指標としての測定意義や, 動物実験で証明さ...
SHIMOZAWA Tatsuo, FUJITA Toshio
血管   26(3) 79-85   Sep 2003
SHIMOSAWA Tatsuo
ホルモンと臨牀   51(8) 731-738   Aug 2003
FUJIKURA T., AKIMOTO R., SAJI F., SHIMOSAWA T., YAKUO I.
耳鼻咽喉科免疫アレルギー   17(2) 72-73   Aug 1999
SHIMOSAWA Tatsuo, FUJITA Toshiro
ホルモンと臨牀   47(8) 87-90   Aug 1999
Ando Katsuyuki, Shimosawa Tatsuo, Tominaga Youko, Fujite Toshiro, Kougame Kouji
Japanese Journal of Cardiovascular Disease Prevention   32(2) 109-114   1997
The importance of hypertension in the development of cardiovascular complications in the elderly (age> 65 years) was examined in subjects who utilized the Kirigaoka-Danchi clinic in Kita-ku, Tokyo, for yearly health checks continuously from 1991 t...
Newly identified peptide, proadrenomedullin N-terminal 20 peptide induces hypotensive action via pertussis toxin-sensitive G-proteins
Hypertension   30(1009-1014)    1997
Hypotensive effect of newly identified peptide, proadrenomedullin N-terminal 20 peptide,
Hypertension   28 325   1996
Nakao Mutsuhiro, Nomura Shinobu, Yoshiuchi Kazuhiro, Kuboki Tomifusa, Suematsu Hiroyuki, Shimozawa Tatsuo, Fujita Toshirou
Jpn J Psychosom Med   35(6) 463-471   1995
The purpose of this paper is to discuss the application of the blood pressure (BP) biofeedback system (the direct method) to the treatment of essential hypertension. The subjects of this study were 10 outpatients with essential hypertension (5 men...
Proadrenomedullin NH2 terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings.
Journal of Clinical Investigation   96 1672   1995
Enhancement of vasoconstrictor respsnse by a non-cal cemic analogue of vitamin D3
Hypertension   21 253   1993
Biochemical Biophysical Research Communications   188(1) 330-335   1992
Tatsuo SHIMOSAWA, Katsuyuki ANDO, Toshiro FUJITA
Japanese Heart Journal   36(6) 797-805   1995
Clinical effects of blood pressure biofeedback treatment on hypertension by auto-shaping
Psychosomatic medicine   59 331   1997
Lancet   350(9089) 1449-1450   1997
American Journal of Hypertension   11(1) 41-45   1998
Biochem Biophps Res Commun   258(2) 453-456   1999
Diminished nocturnal decline in blood pressure in elderly hypertensive patients with lift ventricular hypertrophy
Am Heart J   123(5) 1307-1311   1992
The cardiac functional reserve in elderly hypertensive patients with abnormal diurnd change in blood pressure
J Hypertens   10(2) 173-179   1992
Tatsuo SHIMOSAWA, Koichi KANOZAWA, Ryuji NAGASAWA, Tetsuya MITARAI, Kazuo ISODA, Katsutoshi TAKAHASHI, Katsuyuki ANDO, Yumiko TOZAWA, Miki NAGASE, Nobukazu SASAKI, Megumi FUJITA, Koji TAKANO, Taro IIRI, Toshiro FUJITA
Hypertension Research   23(2) 167-171   2000
J Cardiovascul Pharmacol   37(3) 233-238   2001
Senescence marker protein-30 knockout mouse liver are highly susceptible to TNF-alpha and Fas-mediated apoptosis.
Am J Pathol   161:1273-81    2002
Organ-protective effects of adrenomedullin.
Hypertension Research   41(5):1080-5    2003
Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis.
Am J Pathol   161(4):1273-81.    2002
Ann N Y Acad Sci.   1019:383-7    2004
J Hum Hypertens   19:259-66    2005
Endocr J   52:1-10    2005
Adrenomedullin as a potent antioxidative and antiatherosclerotic substance.
Timely Top Med Cardiovasc Dis.   9:E15    2005

Books etc

 
ARBの新しい展開
下澤達雄
Taylor & Francis   2005   

Research Grants & Projects

 
Salt-sensitive hypertension and vascular dysfunction
科研費: 基盤研究(C)
Project Year: 2017 - 2019    Investigator(s): Tatsuo Shimosawa
Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunction
科研費: 基盤研究(S)
Project Year: 2015 - 2019    Investigator(s): Toshiro Fujita
心腎連関における炎症とキニン系、アンジオテンシン系の役割
JSPS: 特別研究員奨励費
Project Year: 2016 - 2017
Epigenetical regulation in cardiorenal syndrome by sympathetic nerve activity
科研費: 基盤研究(C)
Project Year: 2014 - 2016    Investigator(s): Tatsuo Shimosawa
生活習慣病による進行性腎障害に関わるエピジェネティック異常の解明と診断・治療への応用
科学技術振興機構: CREST
Project Year: 2011 - 2016    Investigator(s): Toshiro Fujita
Protective effect for antioxidative peptide against disruption of blood brain barrier induced ischemic injury
科研費: 基盤研究(C)
Project Year: 2012 - 2014    Investigator(s): Takao Urabe
Investigation of cardio-pulmonary disorder in the animal model of sleep apnea syndrome
科研費: 基盤研究(C)
Project Year: 2011 - 2013    Investigator(s): Koshi Nagai
Mechanisms and diagnosis of salt-sensitive hypertension in view point of epigenetics
科研費: 基盤研究(C)
Project Year: 2011 - 2013    Investigator(s): Tatsuo Shimosawa
Insulin resistance and protective role for antioxidative peptide in ischemic white matter damages
科研費: 基盤研究(C)
Project Year: 2009 - 2011    Investigator(s): Takao Urabe
Clarification of the mechanism of metabolic and vascular regulation by RAMP and its application in metabolic disorders and vascular injuries.
科研費: 基盤研究(B)
Project Year: 2008 - 2010    Investigator(s): Takayuki Shindo
Pathophysiological mechanisms and therapeutic targets in multiple organ damages in metabolic syndrome
科研費: 基盤研究(C)
Project Year: 2008 - 2010    Investigator(s): Tatsuo Shimosawa
Production and characterization of Adrenomedullin (-/-)<->(+/+) and RAMP2(-/-)<-> (+/+) chimeric mice
科研費: 基盤研究(C)
Project Year: 2006 - 2007    Investigator(s): Takayuki Sakurai
Therapeutic potency of platinum nanoparticle in metabolic syndrome
科研費: 基盤研究(C)
Project Year: 2006 - 2007    Investigator(s): Tatsuo Shimosawa
Targeting oxidative stress and new therapy in metabolic syndrome
科研費: 基盤研究(A)
Project Year: 2005 - 2007    Investigator(s): Toshiro Fujita
Therapeutic potency of antioxidative peptide in metabolic syndrome
科研費: 基盤研究(C)
Project Year: 2004 - 2005    Investigator(s): Tatsuo Shimosawa
遺伝子工学を用いた動脈硬化形成とその防御機構の解析―LOX-1とPPARγの役割
科研費: 萌芽研究
Project Year: 2002 - 2003    Investigator(s): Toshiro Fujita
Role of LOX-1 and protective effect of PPARγ in the development of atherosclerosis
科研費: 基盤研究(C)
Project Year: 2002 - 2003    Investigator(s): Katsuyuki Ando
Organ protective effect of adrenomedullin, studies using knockout mice.
科研費: 基盤研究(C)
Project Year: 2001 - 2003    Investigator(s): Tatsuo Shimosawa
Role of oxidized LDL/LOX-1 in the development and progression of renal disease.
科研費: 基盤研究(B)
Project Year: 2000 - 2002    Investigator(s): Toshiro Fujita
PHYSIOLOGICAL ROLE OF ADRENOMEDULLIN BY MOLECULAR BIOLOGICAL AND GENE ENGINEERING APPROACH
科研費: 特定領域研究
Project Year: 1998 - 2002    Investigator(s): Toshiro Fujita
発生工学を用いた食塩感受性高血圧発症機序及び臓器障害進展の研究
科研費: 萌芽的研究
Project Year: 2000 - 2001    Investigator(s): Toshiro Fujita
プロアドレノメデュリンN末端20ペプチド(PAMP)の交感神経系に与える影響、慢性及び内因性PAMPの効果
科研費: 奨励研究(A)
Project Year: 1999 - 2000    Investigator(s): Tatsuo Shimosawa
Regulation of vascular p38 mitogen-activated protein kinase and its role in the vascular function
科研費: 基盤研究(C)
Project Year: 1998 - 1999    Investigator(s): Katsutoshi Takahashi
Multiple mechanisms for vasodilator effect of magnesium
科研費: 一般研究(B)
Project Year: 1991 - 1993    Investigator(s): Toshiro Fujita
Physiology hypotensive peptides
Senile marker protein30 (SMP30) and its physiological role
Renal hemodynamic change and aging