Toru Nishinaka

Profile Information

Affiliation: Associate Professor, Faculty of Phamacy, Osaka Ohtani University

Degree: Doctor of Pharmaceutical Science(Osaka University)

J-GLOBAL ID: 200901040904172928
researchmap Member ID: 1000236058

Research Interests

Research Areas

Research History

2019 - Present

Faculty of Phamacy, Osaka Ohtani University
2007 - 2019

Faculty of Phamacy, Osaka Ohtani University
2006 - 2007

Faculty of Phamacy, Osaka Ohtani University
2002 - 2006

Kyoto Prefectural University of Medicine
1997 - 2002

Kyoto Prefectural University of Medicine
1993 - 1997

University of California, Los Angeles

Education

1988 - 1993

応用薬学専攻, 薬学研究科, 大阪大学大学院
1984 - 1988

School of Pharmaceutical Sciences, Osaka University

Papers

Overexpression of lysophospholipid acyltransferase, <scp>LPLAT10</scp>/<scp>LPCAT4</scp>/<scp>LPEAT2</scp>, in the mouse liver increases glucose‐stimulated insulin secretion

Kahori Shimizu, Moe Ono, Takenari Mikamoto, Yuya Urayama, Sena Yoshida, Tomomi Hase, Shotaro Michinaga, Hiroki Nakanishi, Miho Iwasaki, Tomoyuki Terada …

The FASEB Journal, 38(2), Jan 16, 2024
Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice

Kahori Shimizu, Syogo Nishimuta, Yuri Fukumura, Shotaro Michinaga, Yuka Egusa, Tomomi Hase, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi, Koji Tomita …

PLOS ONE, 17(9) e0274297-e0274297, Sep 13, 2022 Peer-reviewed
Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators.

Satoshi Endo, Yoshifumi Morikawa, Toshiyuki Matsunaga, Akira Hara, Toru Nishinaka

The Journal of steroid biochemistry and molecular biology, 221 106113-106113, Apr 6, 2022 Peer-reviewed
Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells.

Satoshi Endo, Tsubasa Nishiyama, Tomoe Matuoka, Takeshi Miura, Toru Nishinaka, Toshiyuki Matsunaga, Akira Ikari

Chemico-biological interactions, 348 109634-109634, Oct 1, 2021 Peer-reviewed
The Role of AKR1B10 in Physiology and Pathophysiology.

Satoshi Endo, Toshiyuki Matsunaga, Toru Nishinaka

Metabolites, 11(6), May 21, 2021 Peer-reviewed
ZFAND3 Overexpression in the Mouse Liver Improves Glucose Tolerance and Hepatic Insulin Resistance

Kahori Shimizu, Yuya Ogiya, Kaede Yoshinaga, Hajime Kimura, Shotaro Michinaga, Moe Ono, Ayako Taketomi, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi …

Experimental and Clinical Endocrinology & Diabetes, Mar 29, 2021 Peer-reviewed
Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity.

Kahori Shimizu, Fuminori Sakurai, Shunsuke Iizuka, Ryosuke Ono, Tomohito Tsukamoto, Fumitaka Nishimae, Shin-Ichiro Nakamura, Toru Nishinaka, Tomoyuki Terada, Yasushi Fujio …

Journal of immunology (Baltimore, Md. : 1950), 206(2) 410-421, Jan 15, 2021 Peer-reviewed
Dietary calamondin supplementation slows the progression of non-alcoholic fatty liver disease in C57BL/6 mice fed a high-fat diet.

Kahori Shimizu, Yuka Egusa, Syogo Nishimuta, Yuri Fukumura, Misato Yoshimura, Tomoya Inomoto, Tomoyuki Terada, Koji Tomita, Toru Nishinaka

International journal of food sciences and nutrition, 1-13, Aug 30, 2020 Peer-reviewed
Dimeric dihydrodiol dehydrogenase is an efficient primate 1,5-anhydro-D-fructose reductase.

Akira Hara, Toru Nishinaka, Naohito Abe, Ossama El-Kabbani, Toshiyuki Matsunaga, Satoshi Endo

Biochemical and biophysical research communications, 526(3) 728-732, Jun 4, 2020 Peer-reviewed
Cooperative regulation of mouse aldose reductase (AKR1B3) gene transcription by Nrf2, TonEBP, and c-jun.

Nishinaka T, Shimizu K, Miura T, Yabe-Nishimura C, Terada T

Chemico-biological interactions, 302 36-45, Apr, 2019 Peer-reviewed
Post-treatment with JP-1302 protects against renal ischemia/reperfusion-induced acute kidney injury in rats.

Shimokawa T, Tsutsui H, Miura T, Takama M, Hayashi K, Nishinaka T, Terada T, Yoneda K, Yamagata M, Yukimura T

Journal of pharmacological sciences, 139(3) 137-142, Mar, 2019 Peer-reviewed
[The Investigation of Genes, Using an Improved Adenovirus Vector, and Food for the Treatment and Prevention of Type 2 Diabetes Mellitus].

Shimizu K, Nishinaka T, Tomita K, Terada T

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 139(1) 47-51, 2019 Peer-reviewed
Cranberry Attenuates Progression of Non-alcoholic Fatty Liver Disease Induced by High-Fat Diet in Mice.

Shimizu K, Ono M, Imoto A, Nagayama H, Tetsumura N, Terada T, Tomita K, Nishinaka T

Biological & pharmaceutical bulletin, 42(8) 1295-1302, 2019 Peer-reviewed
Inhibition of α2C-adrenoceptors ameliorates cisplatin-induced acute renal failure in rats.

Tsutsui H, Shimokawa T, Miura T, Takama M, Nishinaka T, Terada T, Yamagata M, Yukimura T

European journal of pharmacology, 838 113-119, Nov, 2018 Peer-reviewed
Effect of monoamine oxidase inhibitors on ischaemia/reperfusion-induced acute kidney injury in rats

Hidenobu Tsutsui, Takaomi Shimokawa, Takeshi Miura, Masashi Takama, Toru Nishinaka, Tomoyuki Terada, Masayo Yamagata, Tokihito Yukimura

European Journal of Pharmacology, 818 38-42, Jan 5, 2018 Peer-reviewed
Identification and characterization of functional antioxidant response elements in the promoter of the aldo-keto reductase AKR1B10 gene

Toru Nishinaka, Takeshi Miura, Kahori Shimizu, Tomoyuki Terada

CHEMICO-BIOLOGICAL INTERACTIONS, 276 160-166, Oct, 2017 Peer-reviewed
Vasodilatory effect of nitroglycerin in Japanese subjects with different aldehyde dehydrogenase 2 (ALDH2) genotypes

Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Kazuya Yonezawa

CHEMICO-BIOLOGICAL INTERACTIONS, 276 40-45, Oct, 2017 Peer-reviewed
Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs

Akira Hara, Satoshi Endo, Toshiyuki Matsunaga, Ossama El-Kabbani, Takeshi Miura, Toru Nishinaka, Tomoyuki Terada

BIOCHEMICAL PHARMACOLOGY, 138 185-192, Aug, 2017 Peer-reviewed
Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis.

Kahori Shimizu, Minako Okamoto, Tomoyuki Terada, Fuminori Sakurai, Hiroyuki Mizuguchi, Koji Tomita, Toru Nishinaka

Biochemistry and biophysics reports, 10 192-197, Jul, 2017 Peer-reviewed
Adenovirus Vector-Induced Hepatotoxicity During the Early Phase of Adenoviral Treatment Is Attributed to Inflammatory Cytokine-Induced Leaky Expression of Adenovirus Genes

Kahori Shimizu, Sakurai Fuminori, Shunsuke Iizuka, Masashi Tachibana, Toru Nishinaka, Tomoyuki Terada, Hiroyuki Mizuguchi

MOLECULAR THERAPY, 25(5) 264-265, May, 2017

Misc.

Study of zinc finger AN1-type domain gene transduction by a novel adenovirus vector with lower hepatotoxicity for treatment of diabetes mellitus

K. Shimizu, Y. Ogiya, T. Nishinaka, F. Sakurai, H. Mizuguchi, K. Tomita, T. Terada

HUMAN GENE THERAPY, 27(11) A179-A179, Nov, 2016
Potential Targeting Region for the Specific Inhibition of Human Monomeric Carbonyl Reductases of the Short-Chain Dehydrogenase/Reductase Superfamily

Takeshi Miura, Toru Nishinaka, Tomoyuki Terada

DRUG METABOLISM REVIEWS, 41 54-55, Aug, 2009
COMPARATIVE STUDY OF HUMAN MONOMERIC CARBONYL REDUCTASES IN TISSUE DISTRIBUTION, REDUCTASE ACTIVITY, AND COENZYME SPECIFICITY

Takeshi Miura, Toru Nishinaka, Tomoyuki Terada

DRUG METABOLISM REVIEWS, 39 191-192, 2007
COMPARATIVE STUDY OF HUMAN MONOMERIC CARBONYL REDUCTASES IN TISSUE DISTRIBUTION, REDUCTASE ACTIVITY, AND COENZYME SPECIFICITY

Takeshi Miura, Toru Nishinaka, Tomoyuki Terada

DRUG METABOLISM REVIEWS, 39 263-263, 2007
Inhibition of aldose reductase improves myocardial reperfusion injury by a dual mechanism

K Iwata, K Matsuno, T Nishinaka, C Yabe-Nishimura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 100 86P-86P, 2006
Curcumin induces glutathione S-transferase P1 via antioxidant response element

T Nishinaka, C Yabe-Nishimura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 97 284P-284P, 2005
実験的糖尿病誘発マウスの心臓におけるアルドース還元酵素の活性化

岩田和実, 西中徹, 松野邦晴, 矢部千尋

日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA, 124 17P-18P, Nov 1, 2004
Curcumin activates antioxidant response element-mediated transcription via p38 MAP kinase pathway

T Nishinaka, C Yabe-Nishimura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 94 243P-243P, 2004
Cloning and characterization of human testis specific protein, a novel member of the aldo-keto reductase superfamily

Y Azuma, S Ushijima, J Soh, T Nishinaka, C Yabe, T Miki

JOURNAL OF UROLOGY, 167(4) 322-322, Apr, 2002
ヒト精巣に特異的に発現するアルドース還元酵素関連遺伝子の単離

東勇太郎, 牛嶋壯, 邵仁哲, 河内明宏, 西中徹, 矢部千尋, 三木恒治

日本泌尿器科学会雑誌, 92(2) 415-415, Feb, 2001

Professional Memberships

Research Projects

Study on aldo-keto reductases as potential targets of antitumor agents : its involvement in the drug resistance of cancer cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

NISHINAKA Toru
転写因子Nrf2による薬物代謝酵素の発現調節と薬物相互作用に及ぼす効果の解析

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2002 - 2004

西中徹
酸化的ストレスによる糖尿病合併症発症因子の発現誘導と病態モデルでの解析

科学研究費助成事業, 萌芽的研究, 日本学術振興会, 1999 - 2000

矢部千尋, 岩田和実, 西中徹
薬物代謝酵素の発現および活性の調節機構

西中徹
酸化的ストレス、化学ストレスによって活性化される情報伝達機構に関する研究

西中徹
Regulation of Drug Metabolizing Enzyme Expression and Activity
Study on the signal pathways activated by oxidative stress and chemical stress
糖尿病合併症発症因子の遺伝子発現調節機序の解明と治療への応用

西中徹

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Research Areas

Research History

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Misc.

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