KAKIZAKI Ikuko

J-GLOBAL         Last updated: Feb 27, 2019 at 16:10
 
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Name
KAKIZAKI Ikuko
URL
http://www.med.hirosaki-u.ac.jp/~bioche1/
Affiliation
Hirosaki University
Job title
Associate Professor
Degree
Ph. D.(Hirosaki University), M.A.(Hokkaido University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 1998
 - 
Mar 2007
Research associate, Hirosaki University School of Medicine
 
Jul 2003
 - 
Feb 2004
Pennsylvania State University College of Medicine, U.S.A.
 
Apr 2007
 - 
Dec 2007
Hirosaki University Graduate School of Medicine
 
Jan 2008
 - 
Today
Associate Professor, Hirosaki University Graduate School of Medicine
 

Education

 
 
 - 
1992
pharmacology, Faculty of Pharmaceutical Science, Hokkaido University
 
 
 - 
1994
pharmacology, Graduate School, Division of Pharmaceutical Sciences, Hokkaido University
 
 
 - 
1998
Graduate School, Division of Medicine, Hirosaki University
 

Awards & Honors

 
May 2006
Intelligent Cosmos Encouraging Award
 
May 2006
A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferon., Young Investigator Aword of The Japanese Biochemical Society, Tohoku Branch, The Japanese Biochemical Society, Tohoku Branch
 
Jan 2009
Academic Award, Hirosaki University School of Medicine, Hirosaki University School of Medicine, Japan
 
Jun 2010
Shiseido Female Researcher Science Grant
 

Published Papers

 
Development of new therapeutic agents of preterm birth by glycosaminoglycan
Seigo Tanaka, Ikuko Kakizaki, Kanji Tanaka, Tomoe Kodama, Asami Ito-Fukuyama, Shinichiro Suto, Ryoki Takahashi, Yoshihito Yokoyama
Journal of Hypertension Research in Pregnancy   in press    2019   [Refereed]
Kobayashi T, Kakizaki I, Nakamura T
Analytical biochemistry   568 51-52   Jan 2019   [Refereed]
Yoshida E, Kudo D, Nagase H, Suto A, Shimoda H, Suto S, Kakizaki I, Endo M, Hakamada K
Anticancer research   38(10) 5799-5804   Oct 2018   [Refereed]
Sutoh Yoneyama M, Tobisawa Y, Hatakeyama S, Sato M, Tone K, Tatara Y, Kakizaki I, Funyu T, Fukuda M, Hoshi S, Ohyama C, Tsuboi S
Journal of biochemistry   161(6) 479-492   Jun 2017   [Refereed]
Kobayashi T, Kakizaki I, Nozaka H, Nakamura T
Biochemistry and biophysics reports   9 72-78   Mar 2017   [Refereed]
Nagase H, Kudo D, Suto A, Yoshida E, Suto S, Negishi M, Kakizaki I, Hakamada K
Pancreas   46(2) 190-197   Feb 2017   [Refereed]
Kakizaki Ikuko, Miura Ayako, Mineta Takashi, Hong Jinseo, Kato Yoji
Journal of Applied Glycoscience   64(4) 83-90   2017   [Refereed]
Chanmee T, Ontong P, Izumikawa T, Higashide M, Mochizuki N, Chokchaitaweesuk C, Khansai M, Nakajima K, Kakizaki I, Kongtawelert P, Taniguchi N, Itano N
The Journal of biological chemistry   291(46) 24105-24120   Nov 2016   [Refereed]
Yoshida E, Kudo D, Nagase H, Shimoda H, Suto S, Negishi M, Kakizaki I, Endo M, Hakamada K
Oncology letters   12(4) 2337-2344   Oct 2016   [Refereed]
Uenoyama A, Kakizaki I, Shiomi A, Saito N, Hara Y, Saito T, Ohnuki H, Kato H, Takagi R, Maeda T, Izumi K
Bioscience, biotechnology, and biochemistry   80(7) 1344-1355   Jul 2016   [Refereed]
後藤昌史, 末川裕, 花田友香子, 柿崎育子, 山本和司, 加藤陽治
応用糖質科学   6(2) 138-146   May 2016   [Refereed]
SAWADA Naoya, MIKAMI Kenichiro, IGARASHI Go, ENDO Tetsu, SATO Ken, KAKIZAKI Ikuko, FUKUDA Shinsaku
Hirosaki Medical Journal   66(2/4) 143-151   Mar 2016   [Refereed]
Kakizaki I, Takahashi R, Yanagisawa M, Yoshida F, Takagaki K
Carbohydrate research   413 129-134   Sep 2015   [Refereed]
Tatara Y, Kakizaki I, Suto S, Ishioka H, Negishi M, Endo M
Glycobiology   25(5) 557-569   May 2015   [Refereed]
Kakizaki I, Koizumi H, Chen F, Endo M
Carbohydrate polymers   121 362-371   May 2015   [Refereed]
KAKIZAKI Ikuko, MIURA Ayako, ITO Seiko, MINETA Takashi, JIN SEO Hong, KATO Yoji
J Appl Glycosci   62(3) 115-120 (J-STAGE)   2015   [Refereed]
Suto S, Kakizaki I, Nakamura T, Endo M
Biopolymers   101(3) 189-196   Mar 2014   [Refereed]
Kakizaki I, Mineta T, Sasaki M, Tatara Y, Makino E, Kato Y
Carbohydrate polymers   103 538-549   Mar 2014   [Refereed]
Ontong P, Hatada Y, Taniguchi S, Kakizaki I, Itano N
Biochemical and biophysical research communications   443(2) 666-671   Jan 2014   [Refereed]
Tatara Y, Kakizaki I, Kuroda Y, Suto S, Ishioka H, Endo M
Glycobiology   23(8) 993-1003   Aug 2013   [Refereed]
Wasonga G, Tatara Y, Kakizaki I, Huang X
Journal of carbohydrate chemistry   32(5-6) 392-409   2013   [Refereed]
Time-dependent gene expression and immunohistochemical analysis of the injured anterior cruciate ligament.
Naraoka, T., Ishibashi, Y., Tsuda, E., Yamamoto, Y., Kusumi, T.
Bone Joint Res.   1(10) 238-244   Oct 2012   [Refereed]
Asano K, Kakizaki I, Nakane A
Biochimie   94(6) 1291-1299   Jun 2012   [Refereed]
Kakizaki I, Suto S, Tatara Y, Nakamura T, Endo M
Biochemical and biophysical research communications   423(2) 344-349   Jun 2012   [Refereed]
Fukuyama A, Tanaka K, Kakizaki I, Kasai K, Chiba M, Nakamura T, Mizunuma H
Life sciences   90(13-14) 484-488   Apr 2012   [Refereed]
Endo M, Kakizaki I
Proceedings of the Japan Academy. Series B, Physical and biological sciences   88(7) 327-344   2012   [Refereed]
Kakizaki I, Nukatsuka I, Takagaki K, Majima M, Iwafune M, Suto S, Endo M
Biochemical and biophysical research communications   406(2) 239-244   Mar 2011   [Refereed]
Kakizaki I, Tatara Y, Majima M, Kato Y, Endo M
Archives of biochemistry and biophysics   506(1) 58-65   Feb 2011   [Refereed]
Analysis of functional sugar chains of proteoglycan in the urine from woman with osteoporosis.
Abe, K., Higuchi, T., Mizunuma, H., Kakizaki, I., Endo, M., and Suto, S.
Hirosaki Med. J   61(2–4) 97-103   2011   [Refereed]
Kakizaki, I., Ibori, N., Kojima, K., Yamaguchi, M., and Endo M.
FEBS J.   277(7) 1776-1786   Apr 2010   [Refereed]
Yamaguchi, M., Takagaki, K., Kojima, K., Hayashi, N., Chen, F., Kakizaki, I., Kon, A., and Endo, M.
Glycoconj .J.   27(1) 189–198-198   Jan 2010   [Refereed]
Novel glycosaminoglycan glycotechnology: Method for hybrid synthesis of glycosaminoglycan chains Utilizing Chemo-enzymatic Procedures.
Yamaguchi, M., Kakizaki, I., and Endo, M.
J. Carbohyd. Chem.   29 315-331   2010   [Refereed]
Chen, F., Kakizaki, I., Yamaguchi, M., Kojima, K., Takagaki, K., and Endo, M.
Glycoconj. J.   26(5) 559-566   Jul 2009   [Refereed]
Funahashi, M., Nakamura, T., Kakizaki, I., Mizunuma, H., and Endo, M.
Connect Tissue Res.   50(3) 194-202   2009   [Refereed]
Achur, R. N., Kakizaki, I., Goel, S., Kojima, K., Madhunapantula, S. V., Ohta, M., Kumar, S., Takagaki, K., and Gowda, D. C.
Biochemistry   471(1) 12635-12643   Nov 2008   [Refereed]
Kakizaki, I., Itano, N., Kimata, K., Hanada, K., Kon, A., Yamaguchi, M., Takahashi, T., and Takagaki, K.
Arch. Biochem. Biophys.   471(1) 85-93   Mar 2008   [Refereed]
Morohashi, H., Yoshihara, S., Nakai, M., Yamaguchi, M., Kakizaki, I., Kon, A., Sasaki, M., and Takagaki, K.
International journal of cancer   120(12) 2704-2709   Jun 2007   [Refereed]
Kakizaki, I., Takahashi, R., Ibori, N., Kojima, K., Takahashi, T., Yamaguchi, M., Kon, A., and Takagaki, K.
Biochim. Biophys. Acta.   1770(2) 171– 177-177   Feb 2007   [Refereed]
Morohashi, H., Kon, A., Nakai, M., Yamaguchi, M., Kakizaki, I., Yoshihara S., and Sasaki, M., and Takagaki, K.
Biochem. Biophys. Res. Commun.   345(4) 1454-1459   Jul 2006   [Refereed]
The effects of glycosaminoglycans on thrombopoietin-induced megakaryocytopoiesis.
Kashiwakura, I., Teramachi, T., Kakizaki, I., Takagi, Y., Takahashi, T. A., and Takagaki, K.
Haematologica.   91(4) 445–451-451   Apr 2006   [Refereed]
4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells. 共著
Nakazawa H1, Yoshihara S, Kudo D, Morohashi H, Kakizaki I, Kon A, Takagaki K, Sasaki M.
Cancer Chemother. Pharmacol.   57(2) 165-170   2006   [Refereed]
Yamaguchi, M., Kojima, K., Hayashi, N., Kakizaki, I., Kon A., and Takagaki, K.
Tetrahedron Lett.   47(42) 7455-7458   2006   [Refereed]
Mayer, D.C., Jiang, L., Achur, R.N., Kakizaki, I., Gowda, D.C., and Miller, L.H.
Proc. Natl. Acad. Sci. U. S. A.   103(7) 2358-2362   2006   [Refereed]
Yoshihara S., Kon A., Kudo D., Nakazawa H., Kakizaki I., Sasaki M., Endo M., and Takagaki K.
FEBS Lett.   579(12) 2722-2726   2005   [Refereed]
Kudo, D., Kon, A., Yoshihara, S., Kakizaki, I., Sasaki, M., Endo, M., and Takagaki, K.
Biochem. Biophys. Res. Commun.   321(4) 783-787   2004   [Refereed]
Kakizaki, I., Kojima, K., Takagaki, K., Endo, M., Kannagi, R., Ito, M., Maruo, Y., Sato, H., Yasuda, T., Mita, S., Kimata, K., and Itano, N.
J. Biol. Chem.   279(32) 33281-33289   2004   [Refereed]
Muthusamy, A., Achur, R. N., Valiyaveettil, M., Madhunapantula, S. V., Kakizaki, I., Bhavanandan, V. P., and Gowda, C. D.
Glycobiology   14(7) 635-645   2004   [Refereed]
Takahata, T., Kumano, T., Ookawa, K., Hayakari, M., Kakizaki, I., and Tsuchida, S.
Biochem Pharmacol.   67(9) 1167-1675   2004   [Refereed]
Iwafune, M., Kakizaki, I., Nakazawa, H., Nukatsuka, I., Endo, M.
Anal. Biochem.   325(1) 35-40   2004   [Refereed]
Sasaki, H., Kon, A., Takeda, H., Sawamura, D., Kakizaki, I., Takagaki, K., Hashimoto, I., and Hanada, K.
J Dermatol Sci.   32(3) 239-242   2003   [Refereed]
KAKIZAKI I, TAKAGAKI K, ENDO Y, KUDO D, IKEYA H, MIYOSHI T, BAGGENSTOSS B A, NAKANE A, ENDO M
Eur. J. Biochem.   269(20) 5066-5075   2002   [Refereed]
Iwafune, M., Kakizaki, I., Yukawa, M., Kudo, D., Ota, S., Endo, M., and Takagaki, K.
Biochem. Biophys. Res., Commun.   297(5) 1167-1170   2002   [Refereed]
Ikeda, H., Serria, M. S., Kakizaki, .I, Hatayama, I., Satoh, K., Tsuchida, S., Muramatsu, M., Nishi, S., and Sakai, M.
Biochem. J.   364(2) 563-570   2002   [Refereed]
Takagaki, K., Iwafune, M., Kakizaki, I., Ishido, K., Kato, Y.
J. Biol. Chem.   277(21) 18397-18403   2002   [Refereed]
Takagaki, K., Munakata, H., Kakizaki, I., Iwafne, M., Itabashi, T.
J Biol Chem.   277(11) 8882-8889   2002   [Refereed]
TAKAGAKI K, ISHIDO K, KAKIZAKI I, IWAFUNE M, ENDO M
Biochem. Biophys. Res., Commun. 293(1), 220-4.   293(1) 220-224   2002   [Refereed]
Kukidome, J., Kakizaki, I., Takagaki, K., Matsuki, A., Munakata, A., and Endo, M.
Tohoku J. Exp. Med.   194(1) 23-34   2001   [Refereed]
Studies on sugar chain elongation in cultured human colon adenocarcinoma cells using 4-methylumbeliferyl glycoside derivatives and p-nitrophenyl glycoside derivatives as artificial primers.(共著)
Kukidome, J., Kakizaki, I., Takagaki, K., and Endo, M.: Studies on sugar chain elongation in cultured human colon adenocarcinoma cells using 4-methylumbelliferyl glycoside derivatives and p-nitrophenyl glycoside derivatives as artificial primers.
Hirosaki Med. J.   52 59-65   2001   [Refereed]
Kakizaki, I., Ookawa, K., Ishikawa, T., Hayakari, M., Aoyagi, T., and Tsuchida, S.
Jpn. Cancer Res.   91(11) 1161-1168   2000   [Refereed]
TAKAGAKI K, MUNAKATA H, KAKIZAKI I, MAJIMA M, ENDO M
Biochem. Biophys. Res. Commun.   270(2) 588-593   2000   [Refereed]
Chimeric Glycosaminoglycan Oligosaccharides Synthesized by Enzymatic Reconstruction and Their Use in Substrate Specificity Determination of Streptococcus Hyaluronidase 共著
Takagaki K, Munakata H, Majima M, Kakizaki I, Endo M.
J. Biochem. (Tokyo)   127(4) 695-702   2000   [Refereed]
Identification of Glutathione S-Transferase p-1 as the Class Pi Form Dominantly Expressed in Mouse Hepatic Adenomas 共著
Ookawa K, Nakano H, Kakizaki I, Hatayama I, Kajihara-Kano H, Kimura J, Hayakari M, Takahata T, Satoh K, Tsuchida S.
Jpn. Cancer Res.   89(6) 641-648   1998   [Refereed]
Epitope mapping of a monoclonal antibody to human glutathione transferase P1-1 the binding of which is inhibited by glutathione 共著
Takahata T, Tsuchida S, Oomura M, Matsumoto T, Azumi J, Hatayama I, Hayakari M, Kimura J, Kakizaki I, Kano H, Satoh K, Sato K.
Biochemical Journal   321(2) 531-536   1997   [Refereed]
NISHIMURA H, KAKIZAKI I, MUTA T, SASAKI N, PU P X, YAMASHITA T, NAGASAWA S
FEBS Lett.   357(2) 207-211   1995   [Refereed]
Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene. 共著
Negishi Y, Nishita Y, Saëgusa Y, Kakizaki I, Galli I, Kihara F, Tamai K, Miyajima N, Iguchi-Ariga SM, Ariga H.
Oncogene   9(4) 1133-1143   1994   [Refereed]
Cell cycle-dependent activation of c-myc enhancer.共著
Kakizaki I, Imamura Y, Galli I, Kihara F, Ariga H, Iguchiariga S.
J. Oncol.   2(4) 657-661   1993   [Refereed]

Misc

 
後藤昌史, 加藤陽治, 柿崎育子
Bio Ind   32(11) 45-50   Nov 2015
Development of an enzymatic synthesis method for chimeric glycosaminoglycans.
Takagaki, K., Kakizaki, I., and Endo, M.
Development of an enzymatic synthesis method for chimeric glycosaminoglycans.   51(Suppl.) S49-S53   1999   [Refereed]
Lentinan Enhances Sensitivity of Mouse Colon26 Tumor to cis-Diamminedichloroplatinum(II) and Decreases Glutathione Transferase Expression 共著
Jpn. Cancer Res.   87(11) 1171-1178   1996
Development of an enzymatic synthesis method for chimeric glycosaminoglycans 共著
Hirosaki Med J "Challenging to be A Frantier in the Medical Science of the 21st Century"   51(Suppl.) S49-S53   1999

Books etc

 
Food Hydrocolloids II: Development and Applications
Yoji Kato, Ikuko Kakizaki, Masashi Goto (Part:Contributor)
CMC   Jan 2015   ISBN:978-4-7813-1051-0
Trends in Marine Biotechnology
Yoji Kato, Ikuko Kakizaki (Part:Contributor)
CMC   Nov 2011   ISBN:4781304532
Experimental Glycoscience – Glycochemistry
Kakizaki, I., and Takagaki, K. (Part:Contributor, Endoglycosidases (Glycosaminoglycans))
Springer, Berlin, Germany   2008   
Comprehensive Glycoscience - from Chemistry to Systems Biology
Takagaki, K., and Kakizaki, I. (Part:Contributor, Degradation of glycosaminoglycans)
Elsevier Science B. V., Amsterdam, the Netherlands   2007   
A possible cardiolipin-dependent inhibition mechanism of hyaluronan synthesis by 4-methylumbelliferone in streptococcus equi FM100共著
Hyaluronan 2003 Conference Proceedings” Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications”, edited by Balazs, E., A. and Hascall, V. C., Matrix Biology Institute   2005   
Hyaluronan 2003 Conference Proceedings "Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications"
Kakizaki, I., Baggenstoss, B. A., Tlapak-Simmons, V. L., Nakane, A., Weigel, P. H., Endo, M., and Takagaki, K. (Part:Contributor, A possible cardiolipin-dependent inhibition mechanism of hyaluronan synthesis by 4-methylumbelliferone in streptococcus equi FM100 (p159–163))
Matrix Biology Institute   2005   
New Developments in Glycomedicine
Endo, Y., Funahashi, M., Kakizaki, I., Takagaki, K., Endo, M., and Yokoyama, M. (Part:Contributor, Hyaluronan knockdown extracellular matrix of cultured human skin fibroblasts by use of 4-methylumbelliferone.)
Elsevier Science B. V., Amsterdam, the Netherlands   2001   
Hyaluronan knockdown extracellular matrix of cultured human skin fibroblasts by use of 4-methylumbelliferone. 共著
New Developments in Glycomedicine,Elsevier Science B. V., Amsterdam, the Netherlands.   2001   
Effect of 4-methylumbelliferone on hyaluronan synthesis of Streptococcus equi FM100. 共著
New Developments in Glycomedicine,Elsevier Science B. V., Amsterdam, the Netherlands   2001   
Enzymatic reconstruction of glycosaminoglycan oligosaccharides in New Developments in Glycomedicine
Elsevier Science B. V., Amsterdam, the Netherlands   2001   
Enzymatic reconstruction of glycosaminoglycan oligosaccharides
Takagaki, K., Kakizaki, I., Iwafune, M., Ishido, K. and Endo, M.
Elsevier Science B. V., Amsterdam, the Netherlands   2001   
Formation of hyaluronic acid-knock-down extracellular matrix using 4-methylumbelliferone.
Endo, Y., Takagaki, K., Takahashi, G., Kakizaki, I., Funahashi, M., and Yokoyama, M.
Elsevier Science B. V., Amsterdam, the Netherlands   2000   
Formation of hyaluronic acid-knock-down extracellular matrix using 4-methylumbelliferone.(共著)
Elsevier Science B.V.   2000   
Pi-class glutathione transferase expression and function in mouse neoplasia 共著
"Molecular Medicine : Novel Findings of Gene Diagnosis, Regulation of Gene Expression, and Gene Therapy", edited by Hashimoto et al. (Elsevire)   1999   
New Targets for Cancer Prevention and Therapy
Kakizaki, I., Itano, N., Kimata, K., Kon, A., Yamaguchi, M., Yoshihara, S., Sasaki, M., and Takagaki, K. (Part:Joint Work, An inhibition mechanism of hyaluronan synthesis by 4-methylumbelliferon)
An inhibition mechanism of hyaluronan synthesis by 4-methylumbelliferon, in New Targets for Cancer Prevention and Therapy
Hirosaki University Press, Hirosaki, Japan,   
in press
Degradation of glycosaminoglycan, in Comprehensive Glycoscience - from Chemistry to Systems Biology
Elsevier Science B. V., Amsterdam, the Netherlands   
in press
Endoglycosidases (Glycosaminoglycans) in Glycoscience Lab Manual
Springer, Berlin, Germany   
in press

Conference Activities & Talks

 
Applied research on inhibitor of hyaluronan synthesis
TAKAGAKI Keiichi, 〇KAKIZAKI Ikuko
International Symposium on Extracellular Glycomatrix in Health and Disease   17 Jun 2006   
Control of synthesis and functional analysis of pericellular hyaluronan matrix [Invited]
KAKIZAKI Ikuko
28 Mar 2006   
Enzymatic Reconstruction of Glycosaminoglycans
TAKAGAKI Keiichi, 〇KAKIZAKI Ikuko, KON Atsushi
Joint Meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research   17 Nov 2004   

Research Grants & Projects

 
Inhibition Mechanism of Hyaluronan Synthesis by 4-Methylumbeliferone
Cooperative Research
Project Year: 2001 - 2004