Professor, Graduate School of Medical and Dental Sciences Life Science and Technology Life Science and Technology Immunology, Tokyo Medical and Dental University
Apr 2012
-
Dec 2014
Professor, Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Environmental Response Immunology, Tokyo Medical and Dental University
Apr 2010
-
Today
Professor, Medical Research Institute Pathophysiology Immunology, Tokyo Medical and Dental University
Apr 2003
-
Mar 2010
Director, Tokyo Medical and Dental University
Jul 1996
-
Mar 2003
Professor, Medical Research Institute Pathophysiology Immunology, Tokyo Medical and Dental University
Significant associations of human SIGLEC10 polymorphisms with susceptibility to Guillain-Barré syndrome, Best Presentation Award (Xuexin, Li), Japanese Society for Immunology
Winner: Xuexin, Li
Oct 2017
Eugen-und-Ilse-Seibold-Preis, Eugen and Ilse Seibold Prize, Deutsche Forschungsgemeinschaft
2005
Phillip Franz von Siebold Prize, President of Federal Republic of Germany
Winner: Takeshi Tsubata
This research award was donated by the President of the Federal Republic of Germany on the occasion of his state visit to Japan in 1978. It is awarded annually to a Japanese academic for outstanding services to enhancing mutual understanding of cu...
LAPTM5 promotes lysosomal degradation of intracellular CD3zeta but not of cell surface CD3ζ.
Kawai, Y., Ouchida, R., Yamasaki, S., Dragone, L., Tsubata, T. and Wang, J.-Y.
Immunol. Cell Biol. 92 527-534 Jul 2014
The lysosomal protein LAPTM5 has been shown to negatively regulate cell surface T cell receptor (TCR) expression and T-cell activation by promoting CD3zeta degradation in lysosomes, but the mechanism remains largely unknown. Here we show that LAPT...
Siglecs and B cell regulation. In: Taniguchi N., Endo T., Hart G., Seeberger P., Wong C. (Ed.) Glycoscience: Biology and Medicine
Tsubata, T.
SpringerReference (www.springerreference.com). Springer-Verlag Berlin Heidelberg. Apr 2014
Excess CD40L does not rescue anti-DNA B cells from clonal anergy.
Aslam, M., Kishi, Y. and Tsubata, T.
F1000Res 2 218-218 Jan 2014
CD40L, a member of the tumor necrosis factor (TNF) ligand family, is overexpressed in patients with systemic lupus erythematosus and in lupus mouse models. Previously, we demonstrated that B cells producing pathogenic anti-Sm/RNP antibodies are de...
Takeshi Tsubata, Naoyuki Taniguchi, Tamao Endo, Jun Hirabayashi, Shoko Nishihara, Kenji Kadomatsu, Kazunari Akiyoshi and Kiyoko F Aoki-Kinoshita (Part:Joint Work, Development of Siglec Regulators.)
Springer Sep 2019 ISBN:9811358559
Lectin Purification and Analysis: Methods and Protocols
Alborzian Deh Sheikh, A., Akatsu, C. and Tsubata, T. (Part:Joint Work, Identification of Siglec Cis-ligands by Proximity Labeling.)
Springer 2019
Siglec-2 is a key molecule for immune response. In “Experimental Glycoscience, Glycobiology”
Springer. 2008
Regulation of B cell antigen receptor signaling by CD72. In “Activating and Inhibitory Immunoglobulin-like Receptors”
Sprnger-Verlag Tokyo 2001
Molecular mechanisms for apoptosis induced by siganling through the B cell antigen receptor.
A mouse model for chronic inflammatory diseases spontaneously develops CD4/CD8 double-positive T cell leukemia/lymphoma.[Invited]
P. A. Koni., Ren, M., Tsubata, T., Khleif, S., Maverakis, E. and Shimoda, M.
The 54th Midwinter Conference of Immunologists at Asilomar. 24 Jan 2015
CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulan[Invited]
Matsubara, N., Ishida, H. and Tsubata, T.
Medical Research Institute 40th Anniversary, 13th Surugadai International Symposium & Joint Usage/Research Program of Medical Research Institute International Symposium. 28 Nov 2014
Role of CD22/Siglec2 and its ligand in B lymphocyte activation.[Invited]
Matsubara, N., Takematsu, H., Ishida, H., Tsubata, T.
Joint annual meeting of SFG &JSCR, Integrating Glycoscience from Biology and Chemistry to Medicine. 16 Nov 2014
Synthetic sialosides that regulate CD22/Siglec-2, a B lymphocyte membrane molecule activating SH2-containing phosphatases.[Invited]
Matsubara, N., Ishida, H. and Tsubata, T.
11th International Conference on Protein Phosphatase. 12 Nov 2014
Distinct tolerance mechanisms for anti-DNA and anti-Sm B cells.
Mohammad, A. and Tsubata, T.
Annual Meeting of the Japanese Society for Immunology 11 Dec 2013
The purpose of the present invention is to elucidate a relationship between deregulation of signaling by CD22 and a rapid response of B cells by IgG-BCR and the like, and to provide a method capable of inducing a rapid immune response and defendin...
mri.tmd.ac.jp