2006年9月
Suppressive effect of Clostridium Perfringens-produced heat-stable substance(s) on proliferation of human colon adenocarcinoma HT29 cells in culture
CANCER LETTERS
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- 巻
- 241
- 号
- 2
- 開始ページ
- 228
- 終了ページ
- 234
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.canlet.2005.10.016
- 出版者・発行元
- ELSEVIER IRELAND LTD
Clostridium perfringens has been regarded as one of the intestinal bacteria increasing colon cancer risk. In previous studies, we have shown that the oral administration of C. perfringens culture medium can inhibit the mutagen-induced formation of pre-neoplastic lesions in rat colon, thus proposing the existence of factor(s) preventing colon tumorigenesis in this culture medium. However, the properties of effective factor(s) and the mechanism of this inhibitory action still remain to be investigated. Then, the effect of C. perfringens culture medium on human colon adenocarcinoma HT29 cells was examined. The exposure of HT29 cells to C. perfringens culture medium was found to suppress the proliferation of these cells probably through the reduction of immediate early gene egr-1 expression. These observations suggest that C. perfringens culture medium has a cytostatic action on colon tumor cells, which may be responsible for the prevention of pre-neoplastic formation in rat colon. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.canlet.2005.10.016
- ISSN : 0304-3835
- PubMed ID : 16300879
- Web of Science ID : WOS:000240908700008