論文

査読有り
2004年12月

Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats

FOOD AND CHEMICAL TOXICOLOGY
  • P Bunpo
  • ,
  • K Kataoka
  • ,
  • H Arimochi
  • ,
  • H Nakayama
  • ,
  • T Kuwahara
  • ,
  • Y Bando
  • ,
  • K Izumi
  • ,
  • U Vinitketkumnuen
  • ,
  • Y Ohnishi

42
12
開始ページ
1987
終了ページ
1997
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.fct.2004.06.022
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Effects of the water extract of Centella asiatica Linn. on formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF) and intestinal tumorigenesis in male F344 rats were investigated. Treatment with the extract significantly decreased the number of larger ACF (with four or more crypts per focus) in the large intestine in the early stage, while the number of methylated DNA adducts was not decreased compared with that in the AOM-treated group. In the post-initiation stage, the extract significantly decreased the total number of ACF and the number of larger ACF, accompanied by a decrease in the 5-bromo-2'-deoxyuridine-labeling index and an increase in the induction of apoptotic cells in the colonic mucosa. The incidences of neoplasms, the numbers of adenocarcinomas in the small intestines and entire intestines, and sizes of neoplasms in the entire intestines in rats fed C asiatica extract at a dose of 10 mg/kg were smaller than those in rats given AOM alone (p < 0.05). The extract at a dose of 100 mg/kg significantly reduced the multiplicity of neoplasms in the small intestine (p < 0.05). These results suggest that inhibition of the formation of AOM-induced ACF by C asiatica extract is associated with modification of cell proliferation and induction of apoptosis in colonic crypts and that the extract has a chemopreventive effect on colon tumorigenesis. (C) 2004 Elsevier Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.fct.2004.06.022
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000225252500008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.fct.2004.06.022
  • ISSN : 0278-6915
  • Web of Science ID : WOS:000225252500008

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