MISC

2003年4月

Immunocytochemical localization of prostaglandin F synthase II in the rat spinal cord

BRAIN RESEARCH
  • T Suzuki-Yamamoto
  • ,
  • K Toida
  • ,
  • K Watanabe
  • ,
  • K Ishimura

969
1-2
開始ページ
27
終了ページ
35
記述言語
英語
掲載種別
DOI
10.1016/S0006-8993(02)04244-0
出版者・発行元
ELSEVIER SCIENCE BV

Prostaglandin F synthase has at least two isozymes, i.e. prostaglandin F synthase I and II. Recently, we demonstrated immunocytochemically that prostaglandin F synthase I was localized in neuronal dendrites and somata, and in endothelial cells of blood vessels in the whole area of rat spinal cord. In the present study, we immunocytochemically localized prostaglandin F synthase 11 in ependymal cells and tanycytes surrounding the central canal and in endothelial cells of blood vessels, but not in any neuronal elements at all segmental levels of the rat spinal cord. Immunoelectron microscopy and confocal laser scanning microscopy confirmed these findings and further revealed that strong immunoreactivity was found in the basal processes of the tanycytes. Our present and recent studies using antibodies against the two isozymes of prostaglandin F synthase clearly indicated that they were localized differentially in ependymal (prostaglandin F synthase 11) and neuronal elements (prostaglandin F synthase 1), but were co-localized in blood vessels in the rat spinal cord. The distinct localization of the two isozymes suggests that prostaglandin F-2 has different transcellular biological actions via different cell groups. (C) 2003 Elsevier Science B.V. All rights reserved.

Web of Science ® 被引用回数 : 13

リンク情報
DOI
https://doi.org/10.1016/S0006-8993(02)04244-0
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000182790100003&DestApp=WOS_CPL

エクスポート
BibTeX RIS