2007年4月
Alteration of therapeutic efficacy of lipid microspheres incorporating prostaglandin E-1 by mixing with aqueous solution
Journal of Pharmaceutical Sciences
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- 巻
- 96
- 号
- 4
- 開始ページ
- 935
- 終了ページ
- 943
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/jps.20790
- 出版者・発行元
- JOHN WILEY & SONS INC
To clarify whether the therapeutic efficacy of lipid microspheres incorporating prostaglandin E-1 (lipo-PGE(1)) is altered when mixed and coinfused with clinical solutions, the original lipo-PGE(1) solution (20 mu g/mL) was mixed with three clinical infusion solutions: 0.9% sodium chloride solution, Hartmann's solution, and fat emulsion for parenteral nutrition. These diluted lipo-PGE(1) (2 mu g/mL) solutions were administered to rats, and their hemodynamic and antiplatelet effects were examined. Peripheral blood flow was increased by 76 +/- 4% from the control level when the lipo-PGE(1) solution diluted with the fat emulsion was administered, while it was increased by 43 +/- 6% and 36 +/- 17%, respectively, when the lipo-PGE(1) solutions diluted with 0.9% sodium chloride and Hartmann's solution were administered. As for the antiplatelet effects of the lipo-PGE(1) solutions, the progression of digit gangrene in thromboangiitis obliterans (TAO) rats was significantly suppressed by the administration of lipo-PGE(1) solution diluted with the fat emulsion, but it was not suppressed by lipo-PGE(1) solution diluted with 0.9% sodium chloride. These findings indicate that the therapeutic efficacy of lipo-PGE(1) is decreased when it is mixed with an aqueous solution such as 0.9% sodium chloride.
- リンク情報
- ID情報
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- DOI : 10.1002/jps.20790
- ISSN : 0022-3549
- Web of Science ID : WOS:000245426900019