論文

査読有り 国際誌
2020年12月1日

Impact of remnant healthy pulp and apical tissue on outcomes after simulated regenerative endodontic procedure in rat molars.

Scientific reports
  • Naoki Edanami
  • ,
  • Kunihiko Yoshiba
  • ,
  • Mari Shirakashi
  • ,
  • Razi Saifullah Ibn Belal
  • ,
  • Nagako Yoshiba
  • ,
  • Naoto Ohkura
  • ,
  • Aiko Tohma
  • ,
  • Ryosuke Takeuchi
  • ,
  • Takashi Okiji
  • ,
  • Yuichiro Noiri

10
1
開始ページ
20967
終了ページ
20967
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-78022-w

When regenerative endodontic procedures (REPs) are performed on immature teeth diagnosed with pulp necrosis and apical periodontitis, various healing patterns occur. Furthermore, infected immature teeth with endodontic disorders often exhibit some remnant pulp and apical tissue. Therefore, this study investigated the impact of remnant healthy or fully functional pulp and apical tissue on healing patterns after REPs. Simulated REPs were performed on non-infected immature rat molars with different amounts of remnant pulp and apical tissue. Healing patterns in these teeth were assessed after 28 days. Teeth with 0.81-0.91 mm of remnant pulp healed with pulp-like tissue, dentin, and osteodentin-like dentin-associated mineralized tissue (OSD-DAMT); teeth with 0.60-0.63 mm of remnant pulp healed with pulp-like tissue and OSD-DAMT; teeth with 0.13-0.43 mm of remnant pulp healed with periodontal ligament (PDL)-like tissue, OSD-DAMT, and cementum-like dentin-associated mineralized tissue (CEM-DAMT); and teeth with disorganization of pulp and apical tissues at 0.15-0.38 mm beyond the root apex healed with PDL-like tissue, CEM-DAMT, and intracanal bone (IB). Loss of Hertwig's epithelial root sheath was observed with IB formation. These results showed that four distinct healing patterns occurred after REPs, depending on the preoperative amount of remnant healthy pulp and apical tissue.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-78022-w
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33262423
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708843
ID情報
  • DOI : 10.1038/s41598-020-78022-w
  • PubMed ID : 33262423
  • PubMed Central 記事ID : PMC7708843

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