2017年10月
Iron-Catalyzed anti-Selective Carbosilylation of Internal Alkynes
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- 巻
- 56
- 号
- 43
- 開始ページ
- 13298
- 終了ページ
- 13301
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/anie.201706333
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Reported is the anti-selective carbosilylation of internal alkynes with silylborane and alkyl halides using a FeBr2/DPPE catalyst system. The iron catalyst allows simultaneous introduction of a carbon electrophile and a silicon nucleophile to simple internal alkynes, including diaryl-, dialkyl-, and aryl/alkyl-substituted alkynes, in a highly stereoselective manner. Alkyl halides are applicable as the electrophiles, thereby enabling the synthesis of a variety of tetrasubstituted alkenylsilanes. In addition, syn-selective carbosilylation was achieved through stereoswitching, by using a silylborane having oxygen functionality on the silyl group. This novel iron-catalyzed carbosilylation is a useful tool for expedient synthesis of stereodefined multisubstituted olefins, a fundamental structural motif in organic chemistry.
- リンク情報
- ID情報
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- DOI : 10.1002/anie.201706333
- ISSN : 1433-7851
- eISSN : 1521-3773
- Web of Science ID : WOS:000412755200019