2009年
A Leakage Current Microsensor for Detection of Interaction between an Electrolyte-Entrapping Liposome and Protein
2009 IEEE SENSORS, VOLS 1-3
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- 開始ページ
- 1883
- 終了ページ
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- 記述言語
- 英語
- 掲載種別
- 研究論文(国際会議プロシーディングス)
- DOI
- 10.1109/ICSENS.2009.5398390
- 出版者・発行元
- IEEE
We have newly made a specific biomolecule microsensor measuring leakage current and impedance with minute liposome solution that interacts with biomolecules such as protein. The microsensor was fabricated with a Si surface-bulk-micromachining process. K-4[Fe(CN)(6)] solution was entrapped inside of liposome of 1,2-dipalmitoyl-sn-glycero-3-phosphocholline (DPPC) and Carbonic Anhydrase from Bovine (CAB) was used as added protein for the interaction. A clear leakage in nA order was observed for the CAB, indicating the microsensor detects the CAB through the liposome-protein interaction. The detectivity increased by about 7 times and the volume of solution was decreased by about 10,000 from the previous result.
- リンク情報
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- DOI
- https://doi.org/10.1109/ICSENS.2009.5398390
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000279891700413&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77951095644&origin=inward
- ID情報
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- DOI : 10.1109/ICSENS.2009.5398390
- SCOPUS ID : 77951095644
- Web of Science ID : WOS:000279891700413