論文

査読有り
2017年9月

Population Structure and Local Adaptation of MAC Lung Disease Agent Mycobacterium avium subsp hominissuis

GENOME BIOLOGY AND EVOLUTION
  • Hirokazu Yano
  • Tomotada Lwamoto
  • Yukiko Nishiuchi
  • Chie Nakajima
  • Daria A. Starkova
  • Igor Mokrousov
  • Olga Narvskaya
  • Shiomi Yoshida
  • Kentaro Arikawa
  • Noriko Nakanishi
  • Ken Osaki
  • Ichiro Nakagawa
  • Manabu Ato
  • Yasuhiko Suzuki
  • Fumito Maruyama
  • 全て表示

9
9
開始ページ
2403
終了ページ
2417
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/gbe/evx183
出版者・発行元
OXFORD UNIV PRESS

Mycobacterium avium subsp. hominissuis (MAH) is one of the most common nontuberculous mycobacterial species responsible for chronic lung disease in humans. Despite increasing worldwide incidence, little is known about the genetic mechanisms behind the population evolution of MAH. To elucidate the local adaptation mechanisms of MAH, we assessed genetic population structure, the mutual homologous recombination, and gene content for 36 global MAH isolates, including 12 Japanese isolates sequenced in the present study. We identified five major MAH lineages and found that extensive mutual homologous recombination occurs among them. Two lineages (MahEastAsia1 and MahEastAsia2) were predominant in the Japanese isolates. We identified alleles unique to these two East Asian lineages in the loci responsible for trehalose biosynthesis (treS and mak) and in one mammalian cell entry operon, which presumably originated from as yet undiscovered mycobacterial lineages. Several genes and alleles unique to East Asian strains were located in the fragments introduced via recombination between East Asian lineages, suggesting implication of recombination in local adaptation. These patterns of MAH genomes are consistent with the signature of distribution conjugative transfer, a mode of sexual reproduction reported for other mycobacterial species.

リンク情報
DOI
https://doi.org/10.1093/gbe/evx183
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28957464
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000412147400019&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/gbe/evx183
  • ISSN : 1759-6653
  • PubMed ID : 28957464
  • Web of Science ID : WOS:000412147400019

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