SEKIGUCHI Kiyotoshi

J-GLOBAL         Last updated: Jun 25, 2019 at 15:41
 
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Name
SEKIGUCHI Kiyotoshi
Affiliation
Osaka University
Section
Institute for Protein Research
Job title
Professor
Degree
(BLANK)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2016
 - 
Today
Endowed Chair and Professor, Institute for Protein Research, Osaka University
 
Apr 1998
 - 
Mar 2016
Professor, Institute for Protein Research, Osaka University
 
Oct 2000
 - 
Mar 2006
Project Director, ERATO Sekiguchi Biomatrix Signaling Project
 
Apr 1992
 - 
Mar 1998
Director, Research Institute, Osaka Medical Center for Maternal and Child Health
 
Jul 1991
 - 
Mar 1998
Chief, Division of Pathobiology, Oaka Medical Center for Maternal and Child Health
 

Education

 
Apr 1973
 - 
Mar 1978
Biological Chemistry, Graduate School, Faculty of Science, Osaka University
 
Apr 1969
 - 
Mar 1973
Department of Chemistry, Faculty of Science, Tokyo Institute of Technology
 

Committee Memberships

 
1986
 - 
Today
The Japanese Biochemical Society  Councilor
 
1987
 - 
Today
Japan Society for Cell Biology  Councilor
 
1997
 - 
2007
Japanese Society for Tissue Engineering  Director
 
1998
 - 
Today
Japanese Society for Matrix Biology and Medicine  Councilor
 

Awards & Honors

 
Jun 2017
Distinguished Merit Award, Japanese Society for Matrix Biology and Medicine
Winner: Kiyotoshi Sekiguchi
 
Apr 2016
Award in Science and Technology, R&D Division, Distinguished Service Award from Minister of Edulation, Culture, Sports, Science and Technology, Ministry of Education, Culture, Sports, Science and Technology
Winner: Kiyotoshi Sekiguchi
 
Aug 2015
Award from Minister of Education, Culture, Sports, Science and Technology, Distinguished Service Awards for Industry-Academia-Government Collaboration, Cabinet Office
Winner: Kiyotoshi Sekiguchi
 
Jul 2014
President Award for Research, Osaka University
Winner: Kiyotoshi Sekiguchi
 
Aug 2013
President Award for Research, Osaka University
Winner: Kiyotoshi Sekiguchi
 

Published Papers

 
Sato, Y., Kiyozumi, D., Futaki, S.k, Nakano, I., Shimono, C., Kaneko, N., Ikawa, M., Okabe, M., Sawamoto, K., and Sekiguchi, K.
Mol. Biol. Cell   30(1) 568-68   Jan 2019   [Refereed]
Shibata, S., Hayashi, R., Okubo, T., Kudo, Y., Katayama, T., Ishikawa, Y., Toga, J., Yagi, E., Honma, Y., Quantock, A.J., Sekiguchi, K., and Nishida, K.
Cell Rep.   25(6) 1668-1679   Nov 2018   [Refereed]
Kiyozumi, D., Taniguchi, Y., Nakano, I., Toga, J., Yagi, E., Hasuwa, H., Ikawa, M., and Sekiguchi, K.
Life Science Alliance   1 e201800064   Sep 2018   [Refereed]
Shiokawa, M., Kodama, Y., Sekiguchi, K., Kuwada, T., Tomono, T., Kuriyama, K., Yamazaki, H., Morita, T., Marui, S., Sogabe, Y., Kakiuchi1, N., Matsumori, T., Mima, A., Nishikawa, Y., Ueda, T., Tsuda, M., Yamauchi, Y., Sakuma, Y., Maruno, T., Uza, N., Tsuruyama, T., Mimori, T., Seno, H., and Chiba, T.
Science Translational Medicine   10 eeq0997   Aug 2018   [Refereed]
Respective optimal calcium concentrations for proliferation on type I collagen fibrils in two keratinocyte line cells, HaCaT and FEPE1L-8.
Fujisaki, H., Futaki, S., Yamada, M., Sekiguchi, K., Hayashi, T., Ikejima, T., and Hattori, S.
Regenerative Therapy   8 73-79   Jun 2018   [Refereed]
Takayama, K., Hagihara, Y., Toba, Y., Sekiguchi, K., Sakurai, F. and Mizuguchi, H.
Biomaterials   161 24-32   Jan 2018
Ishii, K., Sakurai, H., Suzuki, N., Mabuchi, Y., Sekiya, I., Sekiguchi, K., and Akazawa, C.
Stem Cell Reports   10 568-582   Jan 2018   [Refereed]
Yoshida, S., Hasegawa, T., Suzuki, M., Sugeno, N., Kobayashi, J., Ueyama, M., Fukuda, M., Ido-Fujibayashi, A., Sekiguchi, K., Ezura, M., Kikuchi, A., Baba, T., Takeda, A., Mochizuki, H., Nagai, Y., Aoki, M.
Hum. Mol. Genet.,   27 823-836   Jan 2018   [Refereed]
Takizawa, M., Arimori, T., Taniguchi, Y., Kitago, Y., Yamashita, E., Takagi, J., and Sekiguchi, K.
Science Advances   3 e1701497   Jun 2017
Kurata, R., Futaki, S., Nakano, I., Fujita, F., Tanemura, A., Murota, H., Katayama, I., Okada, F., and Sekiguchi, K.
PLoS One   12 e0178709   Jun 2017   [Refereed]
Taniguchi, Y., Li, S., Takizawa, M., Oonishi, E., Toga, J., Yagi, E., and Sekiguchi, K.
Biochem. Biophys. Res. Commun.   487 525-531   Apr 2017   [Refereed]
Hayashi, R., Ishikawa, Y., Katori, R., Sasamoto, Y., Taniwaki, Y., Takayanagi, H., Tsujikawa, M., Sekiguchi, K., Quantock, AJ., and Nishida, K.
Nat Protoc.   4 683-696   Apr 2017   [Refereed]
Morooka, N., Futaki, S., Sato-Nishiuchi, R., Nishino, M., Totani, Y., Shimono, C., Nakano, I., Nakajima, H., Mochizuki, N., and Sekiguchi, K.
Circ.Res.   120 1276-1288   Feb 2017   [Refereed]
Karpanen, T., Padberg, Y., van de Pavert, SA., Dierkes, C., Morooka, N., Peterson-Maduro, J., van de Hoek, G., Adrian, M., Mochizuki, N., Sekiguchi, K., Kiefer, F., Schulte, D., and Schulte-Merker, S.
Circ.Res.   120 1263-1275   Feb 2017   [Refereed]
Fujioka, T., Kaneko, N., Ajioka, I., Nakaguchi, K., Omata, T., Ohba, H., Fassler, R., Garc?a-Verdugo, JM., Sekiguchi, K., Matsukawa, N., and Sawamoto, K.
EBioMedicine.   16 195-203   Jan 2017   [Refereed]
Qiao, Y., Tam, J. K., Tan, S. S., Tai, Y. K., Chin, C. Y., Stewart, A. G., Ashman, L., Sekiguchi, K., Langenbach, S. Y., Stelmack, G., Halayko, A. J., and Tran, T.
J. Allergy. Clin. Immunol.   139 82-92   Jan 2017   [Refereed]
Sweat gland stem cells in gland homeostasis and regeneration.
Kurata, R., and Sekiguchi, K.
Skin Care   11(6) 39-43   Dec 2016   [Refereed]
Ohta, R., Niwa, A., Taniguchi, Y., Suzuki, N. M., Toga, J., Yagi, E., Saiki, N., Nishinaka-Arai, Y., Okada, C., Watanabe, A., Nakahara, T., Sekiguchi, K., and Saito, M. K.
Sci. Rep.   6 35680   Nov 2016   [Refereed]
Takayama, K., Mitani, S., Nagamoto, Y., Sakurai, F., Tachibana, M., Taniguchi, Y., Sekiguchi, k., and Mizuguchi, H.
Biochem. Biophys. Res. Commun.,   474 91-96   Mar 2016   [Refereed]
Yamada, M., and Sekiguchi, K.
Current Topics in Membranes   76 197-299   Aug 2015   [Refereed]
Sasaki, K., Yokobayashi, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S., and Saitou, M.
Cell Stem Cell   17(2) 178-194   Jul 2015   [Refereed]
Nakamura, T., Yabuta, Y., Okamoto, I., Aramaki, S., Yokobayashi, S., Kurimoto, K., Sekiguchi, K., Nakagawa, M., Yamamoto, T., and Saitou, M.
Nucleic Acids Res.   43(9) e60   Feb 2015   [Refereed]
Li, X., Qian, H., Takizawa, M., Koga, H., Tsuchisaka, A., Ishii, N., Hayakawa, T., Ohara, K., Sitaru, C., Zillikens, D., Sekiguchi, K., Hirako, Y., and Hashimoto, T.
J. Dermatol. Sci.   77(2) 125-129   Jan 2015   [Refereed]
Kiyozumi D, Sato-Nishiuchi R, Sekiguchi K.
Curr Protoc Cell Biol.   65 10.19.1-10.19.17   Dec 2014   [Refereed]
Kurata, Y., Futaki, S., Nakano, I., Tanemura, A., Murota, H., Katayama, I., and Sekiguchi, K.
Cell Struct. Funct.   39 101-112   Oct 2014   [Refereed]
Yoshino, T., Saito, D., Uchiyama, C., Atsuta, R., Sekiguchi, K., and Takahashi, Y.
Proc. Natl. Acad. Sci. USA.   111 6660-6665   May 2014   [Refereed][Invited]
Doi, D., Samata, B., Katsukawa, M., Kikuchi, T., Morizane, A., Ono, Y., Sekiguchi, K., Nakagawa, M., Parmar, M., and Takahashi, J.
Stem Cell Rep.   2 337-350   Mar 2014   [Refereed]
Nakagawa, M., Taniguchi, Y., Senda, S., Takizawa, N., Ichisaka, T., Asano, K., Morizane, A., Doi, D., Takahashi, J., Nishizawa, M., Yoshida, Y., Toyoda, T., Osafune, K., Sekiguchi, K., and Yamanaka, S.
Sci. Rep.   4 3594   Jan 2014   [Refereed]
Yamada, M., and Sekiguchi, K.
Biochem Biophys Res Commun.   441(4) 988-993   Nov 2013   [Refereed]
Jeong, S., Luo, R., Singer, K., Kreidberg, J., Shimono, C., Kiyozumi, D., Sekiguchi, K. and Piao, X.
PLoS One   8(7) e68781   Jul 2013   [Refereed]
Yamada, M., Mugnai, G., Serada, S., Yagi, Y., Naka, T., and Sekiguchi, K.
Cell Adh. Migr.   7(3) 304-314   May 2013   [Refereed]
Sato, Y., Shimono, C., Li, S., Nakano, I., Norioka, N., Sugiura, N., Kimata, K., Yamada, M., and Sekiguchi, K.
Matrix Biol.   32 188-195   Apr 2013   [Refereed]
Sotiropoulou, P. A., Karambelas, A. E., Debaugnies, M., Candi, A., Bouwman, P., Moers, V., Revenco, T., Rocha, A. S., Sekiguchi, K., Jonkers, J. and Blanpain, C.
Genes Dev.   27(1) 39-51   Jan 2013   [Refereed]
Song, X., Sato, Y., Sekiguchi, K. Tanaka, H., and Ohta, K.
Dev. Dyn.   242(1) 23-29   Jan 2013   [Refereed]
Inagaki, F. F., Tanaka, M., Inagaki, N. F., Yagai, T., Sato, Y., Sekiguchi, K., Oyaizu, N., Kokudo, N., and Miyajima, A.
Biochem. Biophys. Res. Commun.   430 751-756   Jan 2013   [Refereed]
Nasu, M., Takata, N., Danjo, T., Sakaguchi, H., Kadoshima, T., Futaki, S., Sekiguchi, K., Eiraku, M., and Sasai, Y.
PLoS One   7(12) e53024   Dec 2012   [Refereed]
McKee, K. K., Yang, D. H., Patel, R., Chen, Z. L., Strickland, S., Takagi, J., Sekiguchi, K., and Yurchenco, P. D.
J. Cell Sci.   125 4609-4619   Oct 2012   [Refereed]
Song, X., Sato, Y., Felemban, A., Ito, A., Hossain, M., Ochiai, H., Yamamoto, T., Sekiguchi, K. Tanaka, H., and Ohta, K.
Dev. Biol.   368(1) 109-117   Aug 2012   [Refereed]
Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., and Sasai, Y.
Cell Stem Cell   10(6) 771-785   Jun 2012   [Refereed]
Kiyozumi, D., Takeichi, M., Nakano, I., Sato, Y., Fukuda, T., and Sekiguchi, K.
J. Cell Biol.   197(5) 677-689   May 2012   [Refereed]
Fujita, M., Ieguchi, K., Davari, P., Yamaji, S., Taniguchi, Y., Sekiguchi, K., Takada, Y. K., and Takada, Y.
J. Biol. Chem.   287(15) 12491-12500   Apr 2012   [Refereed]
Sengle, G., Tsutsui, K., Keene, D. R., Tufa, S. F., Carlson, E. J., Charbonneau, N. L., Ono, R. N., Sasaki, T., Wirtz, M. K., Samples, J. R., Fessler, L. I., Fessler. J. H., Sekiguchi, K., Hayflick, S. J., and Sakai, L. Y.
PLoS Genet.   8(1) e1002425   Jan 2012   [Refereed]
Fusaoka-Nishioka, E., Shimono, C., Taniguchi, Y., Togawa, A., Yamada, A., Inoue, E., Onodera, H., Sekiguchi, K., and Imai, T.
Neurosci. Res.   71(4) 421-426   Dec 2011   [Refereed]
Saito, M., Kurokawa, M., Oda, M., Oshima, M., Tsutsui, K., Kosaka, K., Nakao, K., Ogawa, M., Manabe, R., Suda, N., Ganjargal, G., Hada, Y., Noguchi, T., Teranaka, T., Sekiguchi, K., Yoneda, T., and Tsuji, T.
J. Biol. Chem.   286(44) 38602-38613   Nov 2011   [Refereed]
Vissers, L. E. L. M., Cox, T. C., Maga, M., Short, K., Wiradjaja, F., Janssen I. M., Jehee, F., Bertola, D., Liu, J., Yagnik, G., Sekiguchi, K., Kiyozumi, D., van Bokhoven H., Marcelis, C., Cunningham, M. L., Anderson, P. J., Boyadjiev, S., Passos-Bueno, M. R., Veltman, J. A., Smyth, I., Buckley, M. F., and Roscioli, T.
PLos Genet.   7(9) e1002278   Sep 2011   [Refereed]
Kiyozumi, D., Osada, A., Sugimoto N., Weber, C. N., Ono, Y., Imai, T., Okada, A., and Sekiguchi, K.
J. Dermatol.   38(7) 674-679   Jul 2011   [Refereed]
Kiyozumi, D., Nakano, I., Takahashi, K. L., Hojo, H., Aoyama, H., and Sekiguchi, K.
Biochem. Biophys. Res. Commun.   411(2) 440-444   Jul 2011   [Refereed]
Goyal, A., Pal, N., Concannon, M., Paul, M., Doran, M., Poluzzi, C., Sekiguchi, K., Whitelock, J. M., Neill, T., and Iozzo, R. V.
J. Biol. Chem.   286(29) 25947-25962   Jul 2011   [Refereed]
Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., and Sasai, Y.
Nature   472(7341) 51-56   Jul 2011   [Refereed]
Xhabija, B., Taylor, G. S., Fujibayashi, A., Sekiguchi, K., and Vacratsis, P. O.
FEBS Lett.   585(12) 1722-1728   Jun 2011   [Refereed]
Mori, T., Kariya, Y., Komiya, E., Higashi, S., Miyagi, Y., Sekiguchi, K., and Miyazaki, K.
Cancer Sci.   102(5) 1095-1100   May 2011   [Refereed]
Fujiwara, H., Ferreira, M., Donati, G., Marciano, D. K., Linton, J. M., Sato, Y., Hartner, A., Sekiguchi, K., and Watt, F. M.
Cell   144(4) 577-589   Feb 2011   [Refereed]
Li, S., Shimono, C., Norioka, N., Nakano, I., Okubo, T., Yagi, Y., Hayashi, M., Sato, Y., Fujisaki H., Hattori, S., Sugiura, N., Kimata, K., and Sekiguchi, K
J. Biol. Chem.   285(47) 36645-36655   Nov 2010   [Refereed]
Ieguchi, K., Fujita, M., Ma, Z., Davari, P., Taniguchi, Y., Sekiguchi, K., Wang, B., Takada, Y., and Takada, Y.
J. Biol. Chem.   285(41) 31388-31398   Oct 2010   [Refereed]
Uchiyama, Y., Sakaguchi, M., Terabayashi, T., Inenaga, T., Inoue, S., Kobayashi, C., Oshima, N., Kiyonari, H., Nakagata, N., Sato, Y., Sekiguchi, K., Miki, H., Fujimura, S., Tanaka, S., Nishinakamura, R.
Proc. Natl. Acad. Sci. USA.   107(20) 9240-9245   May 2010   [Refereed]
Shimono, C., Manabe, R., Yamada, T., Fukuda, S., Kawai, J., Furutani, Y., Tsutsui, K., Ikenaka, K., Hayashizaki, Y., and Sekiguchi, K.
J. Biochem.   147(4) 565-579   Apr 2010   [Refereed]
Miura, S.,Mitsui, K., Heishi, T., Shukunami, C., Sekiguchi, K., Kondo, J., Sato, Y., and Hiraki, Y.
Exp. Cell Res.   316(5) 775-788   Mar 2010   [Refereed]
Katayama, M., Ishizaka, A., Sakamoto, M., Fujishima, S., Sekiguchi, K., Asano, K., Betsuyaku, T., Kotani, T., Ware, L. B., Matthay, M. A., Hashimoto, S.
Intensive Care Med.   36(3) 479-486   Mar 2010   [Refereed]
Tsutsui, K., Manabe, R., Yamada, T., Nakano, I., Oguri, Y., Keene, D. R., Sengle G., Sakai, L. Y., and Sekiguchi, K.
J. Biol. Chem.   285(7) 4870-4882   Feb 2010   [Refereed]
Vuoristo, S., Virtanen, I., Takkunen, M., Palgi, J., Kikkawa, Y., Rousselle, P., Sekiguchi, K., Tuuri, T., Otonkoski, T.
J. Cell Mol. Med.   13(8B) 2622-2633   Aug 2009   [Refereed]
Sato, Y., Uemura, T., Morimitsu, K., Sato-Nishiuchi, R., Manabe, R., Takagi, J., Yamada, M., Sekiguchi, K.
J. Biol. Chem.   284(21) 14524-14536   May 2009   [Refereed]
Taniguchi, Y., Ido, H., Sanzen, N., Hayashi, M., Sato-Nishiuchi, R., Futaki, S., and Sekiguchi, K.
J. Biol. Chem.   284(12) 7820-7831   Mar 2009   [Refereed]
Dainichi, T., Kurono, S., Ohyama, B., Ishii, N., Sanzen, N., Hayashi, M., Shimono, C., Taniguchi, Y., Koga, H., Karashima, T., Yasumoto, S., Zillikens, D., Sekiguchi, K. and Hashimoto, T.
Proc. Natl. Acad. Sci. USA.,   106(8) 2800-2805   Feb 2009   [Refereed]
Yamada, M., Tamura Y., Sanzen, N., Sato-Nishiuchi, R., Hasegawa, H., Ashman, L. K., Rubinstein, E., Yanez-Mo, M., Sanchez-Madrid, F., and Sekiguchi, K.
Biochem. J.   415(3) 417-427   Nov 2008   [Refereed]
Kariya, Y., Kato, R., Itoh, S., Fukuda, T., Shibukawa, Y., Sanzen, N., Sekiguchi, K., Wada, Y., Kawasaki, N and Gu, J.
J. Biol. Chem.   283(48) 33036-33045   Nov 2008   [Refereed]
Ido, H., Ito, S., Taniguchi, Y., Hayashi, M., Nishiuchi, R., Sanzen, N., Hayashi, Y.,Futaki, S., and Sekiguchi, K.
J. Biol. Chem.,   283(42) 28149-28157   Oct 2008   [Refereed]
Miyazaki, T., Futaki, S., Hasegawa, K., Kawasaki, M., Sanzen, N., Hayashi, M., Kawase, E., Sekiguchi, K., Nakatsuji, N., and Suemori, H.
Biochem. biophys. Res. Commun.   375(1) 27-32   Oct 2008   [Refereed]
Manabe, R., Tsutsui, K., Fukuda, T., Yamada, T., Kimura, M., Shimono, C., Nakano, I., Oguri, Y., Shimamoto, K., Sanzen, N., Sato, Y., Kiyozumi, D., Sado, Y., Yamashina, S., Senno, H., Fukuda, S., Sugiura, N., Kawai, J., Kimata, K., Hayashizaki, Y., and Sekiguchi, K.
Proc. Natl. Acad. Sci. USA.   105(35) 12849-12854   Sep 2008   [Refereed]
Gao, J., DeRouen, M. C., Chen, C. H., Nguyen, M., Nguyen, N. T., Ido, H., Harada, K., Sekiguchi, K., Morgan, B. A., Miner, J. H., Oro, A. E., Marinkovich,M. P.
Genes Dev.   22(15) 2111-2124   Aug 2008   [Refereed]
Virtanen, I., Banerjee, M., Palgi, J., Korsgren, O., Lukinius, A., Thornell, L. E., Kikkawa, Y., Sekiguchi, K., Hukkanen, M., Konttinen, Y. T., and Otonkoski, T.
Diabetologia.   51(7) 1181-1191   Jul 2008   [Refereed]
Yamada, M., Sumida, Y., Fujibayashi, A., Fukaguchi, K., Sanzen, N., Sato-Nishiuchi, R., and Sekiguchi, K.
FEBS J.   275(13) 3335-3351   Jul 2008   [Refereed]
Torikai, K., Otsuka, Y., Nishimura, M., Sumida, M., Kawai, T., Sekiguchi, K., and Ueda, I.
Bioorg. Med. Chem.   16(10) 5441-5451   May 2008   [Refereed]
Takashima, S., Yasuo, M., Sanzen, N., Sekiguchi, K., Okabe, M., Yoshida, T., Toda, A., and Nikaido, T.
Tissue Cell   40(2) 75-81   Apr 2008   [Refereed]
Human RME-8 is involved membrane trafficking through early endosomes
Fujibayashi, A., Taguchi, T., Misaki, R., Ohtani, M., Dohmae, N, Takio, K., Yamada, M., Gu, J., Yamakami, M., Fukuda, M., Waguri, S, Uchiyama, Y., Yoshimori, T., Sekiguchi, K.
Cell Struct. Funct.   33 35-50   Jan 2008   [Refereed]
Fujiwara, H., Hayashi, Y., Sanzen, N., Weber, C. N., Emoto, T., Futaki, S., Niwa, H., Murray, P., Edgar, D., and Sekiguchi, K.
J. Biol. Chem.   282(40) 29701-29711   Oct 2007   [Refereed]
Willberg, J., Hormia, M., Takunen, M., Kikkawa, Y., Sekiguchi, K., and Virtanen, I.
J. Periodontol.   78(9) 1810-1818   Sep 2007   [Refereed]
Ido, H., Nakamura, A., Kobayashi, R., Ito, Shunsuke, Li, S., Futaki, S., Sekiguchi, K.
J. Biol. Chem.   282(15) 11144-11154   Apr 2007   [Refereed]
Namba, F., Kitajima, H., Tabata, A., Nakayama, M., Suehara, N., Matsunami, K., Yanagihara, K., Nishihara, M., Morita, A., Yamada, M., Kimoto, A., Hirano, S., Sekiguchi, K., Fujimura, M., Whitsett, J. A., and Yanagihara, I.
Pediatric Res.   60(6) 699-704   Dec 2006   [Refereed]
Niimi, T., Hayashi, Y., Sekiguchi, K., and Kitagawa, Y.
Biochim. Biophys. Acta.   1759 573-579   Nov 2006   [Refereed]
Irving-Rogers, H.F., Friden, B.E., Mason, H.D., Brannstrom, M., Sekiguchi, K., Sanzen, N., Sorokin, L.M., Sado, Y., Ninomiya, Y., and Rodgers, R.J.
Mol. Hum. Reprod.   12(9) 525-534   Sep 2006   [Refereed]
Kiyozumi, D., Sugimoto, N., and Sekiguchi, K.
Proc. Natl. Acad. Sci. USA.   103(32) 11981-11986   Aug 2006   [Refereed]
McDearmon, E. L., Combs, A. C., Sekiguchi, K., Fujiwara, H., and Ervasti, J.
FEBS lett.   580(14) 3381-3385   Jun 2006   [Refereed]
Nishiuchi, R., Takagi, J., Hayashi, M., Ido, H., Yagi, Y., Sanzen, N., Tsuji, T., Yamada, M., and Sekiguchi, K.
Matrix Biol.   25(3) 189-197   Apr 2006   [Refereed]
Ido, H., Harada, K., Yagi, Y., and Sekiguchi, K.
Matrix Biol.   25(2) 112-117   Mar 2006   [Refereed]
Kiyozumi, D., Osada, A., Sugimoto N., Weber, C. N., Ono, Y., Imai, T., Okada, A., and Sekiguchi, K.
Exp. Cell Res.   306(1) 9-23   May 2005   [Refereed]
Osada, A., Kiyozumi, D., Tsutsui, K., Ono, Y., Weber, C. N., Sugimoto N., Imai, T., Okada, A., and Sekiguchi K.
Exp. Cell Res.   303(1) 148-159   Feb 2005   [Refereed]
Nishiuchi, R., Sanzen, N., Nada, S., Sumida, Y., Wada, Y., Okada, M., Takagi, J., Hasegawa, H., and Sekiguchi, K.
Proc. Natl. Acad. Sci. U S A   102(6) 1939-1944   Feb 2005   [Refereed]
24, 326   24:326-332    2005
Futaki, S., Hayashi, Y., Emoto, T., Weber, C. N., Sekiguchi, K.
Mol. Cell. Biol.   24(23) 10492-10503   Dec 2004   [Refereed]
Astrof, S., Crowley, D., George, E. L., Fukuda, T., Sekiguchi, K., Hanahan, D., and Hynes., R.O.
Mol. Cell Biol.   24(19) 8662-8670   Oct 2004   [Refereed]
Association between laminin-8 and glial tumor grade, recurrence and patient survival.
Ljubimova, J. Y., Fugita, M., Khazenzon, N. M., Das, A., Pikul, B.B., Newman, D., Sekiguchi, K., Sorokin, L. M., Sasaki, T., and Black, K. L.
Cancer Sci.   101(3) 604-612   Aug 2004   [Refereed]
Laminin isoforms differentially regulate cell adhesion, spreading , proliferation and ERK activation of b1 integrin-null cells.
300,94-108   300,94-108/,    2004
Ido, H., Harada, K., Futaki, S., Hayashi, Y., Nishiuchi, R., Natsuka, Y., Li, S., Wada, Y., Combs, A.C., Ervasti, J. M., Sekiguchi, K.
J. Biol. Chem.   279(12) 10946-10954   Mar 2004   [Refereed]
J. Mol. Histol.   in press.    2004

Misc

 
Mechanistic basis for the laminin recognition by integrin
Mamoru Takizawa, Takao Arimori, Yukimasa Taniguchi , Junichi Takagi, Kiyotoshi Sekgiuchi
SEIBUTSU BUTSURI   59(2) 91-93   Apr 2019   [Refereed][Invited]
Extracellular marix as stem cell niche
Tsutsui, K., Futaki, S., Sekiguchi, K.
Regenerative Medicine   11(3) 220-238   Sep 2012   [Refereed]
Regulation of EMT by extracellular matrix
Fujiwara, H., Sekiguchi, K.
Cell Technology   27(4) 321-325   Apr 2008
Regulation of emt Regulation of EMT by extracellular matrix.
Saiboukougaku   27:321-325    2008
Customization of the basement membrane components and regulation of morphogenesis
Futaki, S., Sekiguchi, K.
Cell Technology   26(10) 1113-1117   Oct 2007
Regenerative Medicine
CORONA      2007
Customization of the basement membrane composition and regulation of morphogenesis.
Saiboukougaku   26:1113-1117    2007
Engineering of designer extracellular matrix with built-in growth factors
CORONA      2007
Molecular mechanisms of signaling events elicited by extracellular matrices and growth factors
CORONA      2007
Biology of basement membrane proteins.
Nihon-Igakukan      2007
Extracellular matrix as microenvironment for stem cells
Futaki, S., Sekiguchi, K.
BIOINDUSTRY   22(2) 52-55   Feb 2005
Extracellular matrix as a customied extracellular environment
Kiyozumi, D., Sekiguchi, K.
Experimental Medicine   23(1) 52-57   Jan 2005
Yoshitake HAYASHI, Noriko SANZEN, Kiyotoshi SEKIGUCHI
Kobunshi   53(3) 134-139   Mar 2004
Tailor-made extracellular microenvironments for tissue engineering and regenerative medicine
Manabe, R., Sekiguchi, K.
Regenerative medicine   3(2) 13-21   Jun 2004
Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro.
2,985/,    2003
Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro.
Mol. Cancer Ther.   2:985-994    2003
Diversity of Extracellular Matrix and Integrin Signaling, Supplemental Issue of Jikken Igaku on Proteomics and Protein Science
Yodosya      2002
cell recognition and adhesion, Handbook in Biophysics
Asakura Shoten      2002
"Cell-substrate adhesion and signal transduction",in Multicellularity and Cell Adhesion Systems
Kyoritsu Shuppan      2001
Fibronectin Type III Module, Phisiological Sciences
52:468-469    2001
RGD Cell-adhesive Motif, Phisiological Sciences
52:464-465    2001
Analysis of Integrin-mediated Signaling from Laminins, "Seikagaku"
73:1207-1214    2001
Integrin-linked kinase, "Phisiological Sciences"
51: 614-615    2000
fibronectin and disease, "Pathology and clinical Medicine"
病理と臨床   18 : 358-363    2000
Increased extra domain-A containing fibronectin and hepatic dysfunction during septic response: an in vivo and in vitro study.
SHOCK   13:492-496    2000
Cell-substrate adhesion: Overview, in Methos in Extracellular Matrix Research
Collagen Research Association      1999
Regulation of extracellular matrix-integrin interaction
23: 206-212    1997
fibronectin, in "Knockout Mouse Databook"
Nakayama Syoten Co. Ltd.      1997
fibronectin in "Bioscience Library: Cell Adhesion"
Yodosha      1996
integrin, in "Biocience Library: Signal Transduction"
Yodosha      1995
E. SAKASHITA, N. KOBAYASHI, K. MIYASHITA, K. HINO, R. UMEMOTO, M. YONEKAWA, A. KAWAMURA, H. HIRANO, K. SEKIGUCHI, T. KOMAI, M. MATSUDA
Jinko Zoki   23(2) 511-517   1994
Matrix assembly of fibronectin: Molecular mechanisms and its application to matrix engineering,Biomedical Perspectives
3(1) 58   1994
Structure and Functions of Adhesive Proteins: Fibronectin, vitronectin,thrombospondin, and Integrins, "Thrambosis, Hemostasis, and Fibrinolysis"
Chugai Igakusha      1994
Tumor metastasis and extracellular matrix
Akamatsu, H., and Sekiguchi, K.
Biotherapy   7(8) 1181-1188   Jul 1993   [Invited]
Cell-substrate Adhesion in Oncogenic transformation, in "Proteins, A New Frontier in Bioscience"
Kubapuro      1993
Engineering of artificial cell adhesive proteins by grafting oligopeptide motifs derived from fibronectin and laminin.
In New Functionality Materials, Vol. B: Design, Preparation and Control (Tsuruta,T., Seno,M. & Doyama,M., eds.), Elsevier Science Publishers      1993
Fibronectin matris assembly, in "Methos in Biochemistry", Vol.10, "Blood Vessels, Endothelium, and Smooth Muscle Ceels
Tokyo Kagakudojin      1993
Cell adhesion molecules: Integrin family proteins,
Irie, A., Sekiguchi, K.
Mebio   10(5) 18-25   May 1993   [Invited]
Diversities of adhesive signals: fibronectin and laminin as models, "Tissue Culture"
19(4) 117   1993
Frontiers in Glycoscience, Fibronectins and cellular recognition
4(3) 43   1993
Extracellular matrix as cell-regulating supramolecular assemblies, "Experimental Medicine"
11(2) 117   1993
Cellular fibronectin in plasma: Its implications in fibrinogen-associated cryoprecipitation and other related reactions.
Blood Coagulation and Fibrinolysis   4:127-131    1993
Fibronectin matrix assembly, "Experimental Medicine"
11(2) 119   1993
Fibronectins: structure and matrix assembly, "Metabdism"
29(10) 947   1992
Human fibroblast WI-38, "Handbook of Cultured Cells", SEITAI NO KAGAKU
Igaku Syoin      1992
Purification of Fibronectins, in Methods in Biochemistry, Vol.6 Biomembranes and Ion Trdusport
Tokyo Kagakudojin      1992
Artificial adhesion protein, "Polymer Sciences"
40(9) 638   1991
Malignancy-associated Changes in Extracellular Matrix Proteins, in Protein Engineering in Cancer Research
Kodansya Scientific      1991
Cancer Cells, in Human Molecular Genetics
Kodansya Scientific      1991
Artificial cell adhesive proteins engineered by grafting cell adhesive oligopeptide signals.
In Fundamental Investigations on the Creation of Biofunctional Materials (Okamura,S., et al,Ed.), Kagaku-Dojin, Kyoto      1991
Artificial cell adhesive proteins.
26,39   26,39    1991
Urinary fibronectin fragments (a potential tumor marker) measured by immunoenzymometric assay with domain-specific monoclonal antibodies.
Clin. Chem.   37:466-471    1991
Antibodies raised against oligopeptides of human dopamine-β-Hydroxylase.
Neurosci. lett.   120:141-145    1990
Fu\ibronectin and related proteins, "SEITAI NO KAGAKU", New Proteins
Igaku Syoten      1990
Cell adhesion molecules and cancer, "BYORI TO RINSHO"
8,186    1990
Artificial adhesive protins, "Pathophysiology"
9(7) 527   1990
Aberrdtion of Extracellular Matrix Proteins in Malignancy in Prognostic Factors in Human Cancer
Kyowa Kikaku Tsushin      1990
Specific induction of fibronectin gene in rat liver by thyroid hormone.
Mol. Endocrinol.   4:693-699    1990
Engineering of cell adhesive proteins by isertion of the Arg-Gly-Asp-Ser tetrapeptide.
In Protein Engineering: Protein Design in Basic Research, Medicine, and Industry (Ikehara, M., ed.), Japan Scientific Societies Press      1990
RGD-type cell adhesion molecules and platelet functions, "Blood and Vasculature"
20483    1989
Oncogenic modulation of alternative splicing of fibronectin pre-mRNA, "Seikagaku"
61(2) 89   1989
fibronectin: a prototype of cell adhesion molecules, "Cell Technology"
Sekiguchi, K.
Cell Technology   4(6) 485-497   Jun 1985
Fibronectin, laminin, and other extracellular matrix glycoproteins.
In Extra- cellular Matrix Biochemistry (Piez, K.A., & Reddi, A. H., eds.), Elsevier Science Publishing Co. Inc.      1984
Membrane biology of cancer cells, "Cell Recognition and Membranes"
Kagaku Dojin      1983
Fibronectins and Cancercells, in Cell Recognition and Animal Lectins
Kodansya Scientific      1982
Mechanisms of virus-induced cell fusion
Sekiguchi, K., Asano, A.
Metabolism   15(11) 29-37   Nov 1978

Books etc

 
New Functionality Materials: synthesis and Function Control of Biofunctionality Materials (Tsuruta, T., Toyama, M., Seno, M., and Imanishi, Y. ends)
SEKIGUCHI Kiyotoshi (Part:Contributor, Engineering of artificial cell adhesive proteins by grafting oligopeptide motifs derived from fibronectin and laminin (pp.321-326))
Elsevier   1993   

Conference Activities & Talks

 
Next-generation culture substrates for stem cells based on matrixome research [Invited]
SEKIGUCHI Kiyotoshi
The 26th annual Meeting of the Japanese Society for the Research of Hepatic Cells   24 May 2019   
Development of culture substrates for stem cells [Invited]
SEKIGUCHI Kiyotoshi
Advances in Cell Manufacturing Technologies for Regenerative Medicine   21 Dec 2018   
Next-generation culture substrates for stem cells based on matrixome research [Invited]
SEKIGUCHI Kiyotoshi
The 16th Annual Symposium of Japan Consortium for Glycobiology and Glycotechnology   27 Nov 2018   
Mechanistic basis for the laminin recognition by integrin [Invited]
SEKIGUCHI Kiyotoshi
Biennial Meeting of American Society for Matrix Biology   15 Oct 2018   
Designer culture substrates based on laminin E8 fragments for robust expansion and differentiation of human pluripotent stem cells [Invited]
SEKIGUCHI Kiyotoshi
5th TERMIS World Congress: 2018 Kyoto   26 Sep 2018   

Research Grants & Projects

 
Development of Manufacturing Systems for Human iPS Cell-derived Products for Regenerative Medicine
Japan Agency for Medical Research and Development: Project Focused on Developing Key Evaluation Technology: Manufacturing Technology for Industrialization in the Field of Regenerative Medicine
Project Year: May 2014 - Mar 2019    Investigator(s): Masahiro Kinooka
Development of culture substrates for stem cells
Japan Agency for Medical Research and Development: Research Center Network for Realization of Regenerative Medicine
Project Year: Aug 2013 - Mar 2018    Investigator(s): SEKIGUCHI Kiyotoshi
Biochemical Studies on Cell Adhesion Molecules
Design of Artificial Extracellular Environment

Patents

 
特願2015-142732 : Method for inducing vascular endothelial cells
Kiyotoshi Sekguchi
特許第6278324号 : Method for enhancing activity of laminin fragments as cell culture matrix
SEKIGUCHI Kiyotoshi
特許第6101351号 : Cell culture vessel coated with laminin fragment in dry state
SEKIGUCHI Kiyotoshi
特許第5858411号 : Modified laminin containing collagen binding molecule and use thereof
SEKIGUCHI Kiyotoshi
特許第6281979号 : Novel integrin α9β1 ligand and uses thereof
SEKIGUCHI Kiyotoshi

Social Contribution

 
Rational design of next-generation biomaterials based on comprehensive understanding of extracellular matrices
[Lecturer, Informant, Contribution]  Japan Science and Technology Agency  Workshop on Next-generation Biomaterials  3 Mar 2018