東純一 (Jyunichi Azuma) - マイポータル

基本情報

所属: 兵庫医療大学教授

J-GLOBAL ID: 200901036220387600
researchmap会員ID: 1000245387

研究キーワード

研究分野

学歴

- 1971年

大阪大学, 医学部, 医学
- 1971年

大阪大学

委員歴

2000年

臨床薬理学会, 理事

受賞

1986年

上原記念生命科学財団研究奨励賞

MISC

224

Effect of 5-HT1A Gene Polymorphisms on Antidepressant Response in Major Depressive Disorder

Masaki Kato, Tsuyoshi Fukuda, Masataka Wakeno, Gaku Okugawa, Yoshiteru Takekita, Syunsuke Watanabe, Megumi Yamashita, Yuka Hosoi, Junichi Azuma, Toshihiko Kinoshita …

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 150B(1) 115-123 2009年1月
Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: Comparison with Korean, Chinese, and Caucasian populations

S. P. Myrand, K. Sekiguchi, M. Z. Man, X. Lin, R-Y Tzeng, C-H Teng, B. Hee, M. Garrett, H. Kikkawa, C-Y Lin …

CLINICAL PHARMACOLOGY & THERAPEUTICS 84(3) 347-361 2008年9月
Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes

Yasuhiro Yamamoto, Yuki Hoshino, Takashi Ito, Tetsuro Nariai, Tomomi Mohri, Masanori Obana, Nozomi Hayata, Yoriko Uozumi, Makiko Maeda, Yasushi Fujio …

CARDIOVASCULAR RESEARCH 79(1) 89-96 2008年7月
Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways

Xiao-Long Hou, Kyoko Takahashi, Ken Tanaka, Katsuhiko Tougou, Feng Qiu, Katsuko Komatsu, Koichi Takahashi, Junichi Azuma

INTERNATIONAL JOURNAL OF PHARMACEUTICS 358(1-2) 224-229 2008年6月
Antidepressant response and intolerance to SSRI is not influenced by G-protein beta 3 subunit gene C825T polymorphism in Japanese major depressive patients

Masaki Kato, Masataka Wakeno, Gaka Okugawa, Tsuyoshi Fukada, Yoshiteru Takekita, Yuka Hosoi, Junichi Azuma, Toshihiko Kinoshita, Alessandro Serretti

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 32(4) 1041-1044 2008年5月
Connective tissue growth factor induces cardiac hypertrophy through Akt signaling

Nozomi Hayata, Yasushi Fujio, Yasuhiro Yamamoto, Tomohiko Iwakura, Masanori Obana, Mika Takai, Tomomi Mohri, Shinpei Nonen, Makiko Maeda, Junichi Azuma

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 370(2) 274-278 2008年5月
Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy

Takashi Ito, Yasushi Kimura, Yoriko Uozumi, Mika Takai, Satoko Muraoka, Takahisa Matsuda, Kei Ueki, Minoru Yoshiyama, Masahito Ikawa, Masara Okabe …

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 44(5) 927-937 2008年5月
MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients

Makiko Maeda, Isamu Yamamoto, Masakatsu Fukuda, Takashi Motomura, Mari Nishida, Shinpei Nonen, Soji Kasayama, Yasushi Fujio, Junichi Azuma

JOURNAL OF DIABETES AND ITS COMPLICATIONS 22(2) 119-125 2008年3月
ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder.

Prog Neuropsychopharmacol Biol Psychiatry. 32(2):398-404. 2008年
Intraocular Pressure-Lowering Effects and Safety of Topical Administration of a Selective ROCK Inhibitor, SNJ-1656, in Healthy Volunteers.

Arch Ophthalmol. 126(3):309-315. 2008年
Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2

Ryuji Kubota, Masako Ohno, Tomoko Hasunuma, Hajime Iijima, Junichi Azuma

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 63(10) 927-933 2007年10月
Delirium associated with paroxetine in an elderly depressive patient: A case report

M. Wakeno, G. Okugawa, Y. Takekita, M. Kato, T. Fukuda, M. Yamashita, Y. Hosoi, J. Azuma, T. Kinoshita

PHARMACOPSYCHIATRY 40(5) 199-200 2007年9月
Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes

Takashi Ito, Koko Asakura, Katsuhiko Tougou, Tsuyoshi Fukuda, Ryuji Kubota, Shinpei Nonen, Yasushi Fujio, Junichi Azuma

MOLECULAR PHARMACOLOGY 72(1) 173-181 2007年7月
Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1 alpha,25 dihydroxyvitamin D-3 treated Caco-2 cells

Xiao-Long Hou, Kyoko Takahashi, Natsumi Kinoshita, Feng Qiu, Ken Tanaka, Katsuko Komatsu, Koichi Takahashi, Junichi Azuma

INTERNATIONAL JOURNAL OF PHARMACEUTICS 337(1-2) 169-177 2007年6月
Pharmacokinetics of Aripiprazole, a New Antipsychotic, following Oral Dosing in Healthy Adult Japanese Volunteers: Influence of CYP2D6 Polymorphism.

Drug Metab Pharmacokinet. 22(5):358-366. 2007年
Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males.

Biol Pharm Bull. 30(11):2154-2158. 2007年
Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes.

J Biol Chem. 282, 1152-1160 2007年
Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress.

Biochem. Biophys. Res. Commun. 353, 1023-1027 2007年
Polymorphisms of norepinephrine transporter and adrenergic receptor alpha(1D) are associated with the response to beta-blockers in dilated cardiomyopathy.

Pharmacogenomics J. 2007年
Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals.

Drug Metab. Pharmacokinet. 22(2): SNP18(125)-SNP21(128) 2007年

もっとみる

所属学協会

Works(作品等)

ゲノム情報を応用する臨床薬理学的研究

2000年
Clinical Pharmacogenomics

2000年
心不全の病態に関する研究

1995年
Research on Mechanism of Cardiac Failure

1995年

共同研究・競争的資金等の研究課題

臨床ゲノム薬理学

その他の研究制度
心不全の病態に関する研究

その他の研究制度
臨床薬理学

その他の研究制度
ゲノム薬理学に基づく個別化医療推進のための基盤研究

その他の研究制度
Clinical Pharmacogenomics

The Other Research Programs
Study on the moleculor mechanism of cardiac failure

The Other Research Programs
Clinical Pharmacology

The Other Research Programs