J-GLOBAL         Last updated: Jan 14, 2020 at 20:12
Former Institution / Organization Osaka University Graduate School of Pharmaceutical Sciences Applied Biopharmaceutical Sciences
Job title
Research assistant
(BLANK)(Osaka University)

Research Areas


Awards & Honors

Jul 2018
Chromium (VI)-induced transformation is enhanced by Zn deficiency in BALB/c 3T3 cells, Pfizer Awards, The Japanese Society of Toxicology
Jul 2018
LRI Award, The Japanese Society of Toxicology
Mar 2018
Advanced study for toxicity induced by hazards in the aquatic environment via signaling pathways of nuclear receptors, Award for Divisional Scientific Promotion, The Pharmaceutical Society of Japan
Jul 2012
Young Scientist Award, Japan Society for Biomedical Research on Trace Elements
Jul 2007
Young Scientist Award, The Japanese Society of Toxicology
Young Scientist Award, The Pharmaceutical Society of Japan, Division of Pharmaceutical Health Sciences and Environmental Toxicology
Young Scientist Award, The Pharmaceutical Society of Japan Kinki Branch
Young Scientist Award, The Academy of Pharmaceutical Science and Technology, Japan
Winner: NAKANISHI, Tsuyoshi

Published Papers

Elza S. S. Fonseca, Youhei Hiromori, Yoshifumi Kaite, Raquel Ruivo, João N. Franco, Tsuyoshi Nakanishi, Miguel M. Santos, L. Filipe C. Castro
Genes   10(12) 985   Dec 2019   [Refereed]
Signalling molecules and their cognate receptors are central components of the Metazoa endocrine system. Defining their presence or absence in extant animal lineages is critical to accurately devise evolutionary patterns, physiological shifts and ...
Ichiro Yoshida, Keishi Ishida, Hiroshi Yoshikawa, Sho Kitamura, Youhei Hiromori, Yasushi Nishioka, Akiko Ido, Tomoki Kimura, Jun-ichi Nishikawa, Jianying Hu, Hisamitsu Nagase, Tsuyoshi Nakanishi
Journal of Hazardous Materials   in press    Oct 2019   [Refereed]
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), commonly referred to simply as "dioxin", is a persistent environmental pollutant. Because of its high environmental persistence and biological accumulation, humans and animals are often exposed to TCDD. ...
Wenxin Hu, Yingting Jia, Qiyue Kang, Hui Peng, Haojia Ma, Shiyi Zhang, Youhei Hiromori, Tomoki Kimura, Tsuyoshi Nakanishi, Lemin Zheng, Yifu Qiu, Zhaobin Zhang, Yi Wan, Jianying Hu
Environmental Health Perspectives   127(11) 117003   Nov 2019   [Refereed]
Tomoki Kimura, Takuomi Hosaka, Tsuyoshi Nakanishi, Osamu Aozasa
The Journal of Toxicological Sciences   44(4) 309-316   Apr 2019   [Refereed]
Cadmium, a ubiquitous heavy metal, is a toxic industrial and environmental pollutant. The initial biological response to cadmium exposure is induction of metallothioneins (MTs), a family of cysteine-rich, low-molecular-weight proteins that bind pr...
Ana M.F. Capitao, Ana M.F. Capitao, Mónica S. Lopes-Marques, Yoichiro Ishii, Raquel Ruivo, Elza S.S. Fonseca, Elza S.S. Fonseca, Inês Páscoa, Rodolfo P. Jorge, Mélanie A.G. Barbosa, Mélanie A.G. Barbosa, Youhei Hiromori, Youhei Hiromori, Takayuki Miyagi, Tsuyoshi Nakanishi, Miguel M. Santos, Miguel M. Santos, L. Filipe C. Castro, L. Filipe C. Castro
Environmental Science and Technology   52(23) 13951-13959   Dec 2018   [Refereed]
© Copyright 2018 American Chemical Society. Globally persistent man-made chemicals display ever-growing ecosystemic consequences, a hallmark of the Anthropocene epoch. In this context, the assessment of how lineage-specific gene repertoires influe...
Kerstin Törner, Tsuyoshi Nakanishi, Tomoaki Matsuura, Yasuhiko Kato, Yasuhiko Kato, Hajime Watanabe
PLoS ONE   13 e0198023   Jun 2018   [Refereed]
© 2018 Törner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Yasushi Nishioka, Yasushi Nishioka, Kazuki Tamai, Masanari Onda, Youhei Hiromori, Youhei Hiromori, Tomoki Kimura, Jianying Hu, Hisamitsu Nagase, Tsuyoshi Nakanishi
Biological and Pharmaceutical Bulletin   41(2) 266-271   Jan 2018   [Refereed]
© 2018 The Pharmaceutical Society of Japan. Corn oil, sesame oil, and 10% ethanol in corn oil are commonly used as dosing vehicles in toxicology studies. Since these vegetable oils contain bioactive compounds, it is important for toxicology studie...
Erina Shiraishi, Akiko Ido, Youhei Hiromori, Kento Tanaka, Tomoki Kimura, Hisamitsu Nagase, Tsuyoshi Nakanishi
Fundamental Toxicological Sciences   4(3) 121-126   Jun 2017   [Refereed]
Wenxin Hu, Fumei Gao, Hong Zhang, Youhei Hiromori, Youhei Hiromori, Shuhei Arakawa, Hisamitsu Nagase, Tsuyoshi Nakanishi, Jianying Hu
Environmental Science and Technology   51(7) 4061-4068   Apr 2017   [Refereed]
© 2017 American Chemical Society. 2-Ethylhexyl diphenyl phosphate (EHDPP), an organophosphate flame retardant (OPFR), is frequently detected in human blood. In this study, the sensitive dual-luciferase reporter gene assay and molecular docking wer...
Akiko Ido, Youhei Hiromori, Youhei Hiromori, Liping Meng, Haruki Usuda, Hisamitsu Nagase, Min Yang, Jianying Hu, Tsuyoshi Nakanishi
Scientific Reports   7 45931   Apr 2017   [Refereed]
Fibrates, which are widely used lipidaemic-modulating drugs, are emerging environmental pollutants. However, fibrate concentrations in the environment have not been thoroughly surveyed. Here, we determined concentrations of the most commonly used ...
Zhaobin Zhang, Ying Hu, Ying Hu, Jilong Guo, Tong Yu, Libei Sun, Xuan Xiao, Desheng Zhu, Tsuyoshi Nakanishi, Youhei Hiromori, Youhei Hiromori, Junyu Li, Xiaolin Fan, Yi Wan, Siyu Cheng, Jun Li, Xuan Guo, Jianying Hu
Nature Communications   8 14585   Mar 2017   [Refereed]
© The Author(s) 2017. Bisphenol A (BPA) is used in the production of plastic but has oestrogenic activity. Therefore, BPA substitutes, such as fluorene-9-bisphenol (BHPF), have been introduced for the production of so-called 'BPA-free' plastics. H...
Al Sayed Al-Soudy, Tsuyoshi Nakanishi, Seiya Mizuno, Yoshikazu Hasegawa, Hossam H. Shawki, Megumi C. Katoh, Walaa A. Basha, Abdelaziz E. Ibrahim, Hany A. El-Shemy, Hiroyoshi Iseki, Atsushi Yoshiki, Youhei Hiromori, Hisamitsu Nagase, Satoru Takahashi, Hisashi Oishi, Fumihiro Sugiyama
Genesis   54(7) 389-397   Jul 2016   [Refereed]
© 2016 Wiley Periodicals, Inc. Spermatogenesis is a complex and highly regulated process by which spermatogonial stem cells differentiate into spermatozoa. To better understand the molecular mechanisms of the process, the Cre/loxP system has been ...
Akira Aoki, Kohei Fujitani, Kohei Takagi, Tomoki Kimura, Hisamitsu Nagase, Tsuyoshi Nakanishi
Biological and Pharmaceutical Bulletin   39(4) 587-592   Apr 2016   [Refereed]
© 2016 The Pharmaceutical Society of Japan. The steroid hormones synthesized by the male gonads play diverse roles in biological processes. An-drogens, the primary hormones produced by the male gonads, are key regulators of fat homeostasis, hence ...
Youhei Hiromori, Youhei Hiromori, Akiko Ido, Akira Aoki, Tomoki Kimura, Hisamitsu Nagase, Tsuyoshi Nakanishi
Biological and Pharmaceutical Bulletin   39(10) 1596-1603   Jan 2016   [Refereed]
© 2016 The Pharmaceutical Society of Japan. We investigated the ability of group 15 compounds with a triphenyl substituent to bind to and activate human retinoic X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) γ and their ab...
Youhei Hiromori, Youhei Hiromori, Hiroki Yui, Jun Ichi Nishikawa, Hisamitsu Nagase, Tsuyoshi Nakanishi
Journal of Steroid Biochemistry and Molecular Biology   155 190-198   Jan 2016   [Refereed]
© 2014 Elsevier Ltd. All rights reserved. Organotin compounds, such as tributyltin (TbT) and triphenyltin (TPT), are typical environmental contaminants and suspected endocrine-disrupting chemicals because they cause masculinization in female mollu...
Hong Zhang, Zhaobin Zhang, Tsuyoshi Nakanishi, Yi Wan, Youhei Hiromori, Hisamistu Nagase, Jianying Hu
Chemical Research in Toxicology   28(6) 1196-1204   Jun 2015   [Refereed]
© 2015 American Chemical Society. The present study investigated the human constitutive androstane receptor (CAR) binding activities of 23 phthalate esters and 10 phthalate monoesters using a fast and sensitive human CAR yeast two-hybrid assay. Of...
Akiko Ido, Miki Niikawa, Shinji Ishihara, Yoshinari Sawama, Tsuyoshi Nakanishi, Yasunari Monguchi, Hironao Sajiki, Hisamitsu Nagase
Journal of Environmental Health Science and Engineering   13 9   Feb 2015   [Refereed]
Youhei Hiromori, Youhei Hiromori, Akira Aoki, Jun ichi Nishikawa, Hisamitsu Nagase, Tsuyoshi Nakanishi
Metallomics   7 1180-1188   Jan 2015   [Refereed]
© The Royal Society of Chemistry. Organotins, such as tributyltin (TBT) and triphenyltin (TPT), may disrupt endocrine activity in mammals arising from their ability to act as ligands for the retinoid X receptor (RXR) and the peroxisome proliferato...
Tomoki Kimura, Akira Onodera, Akira Onodera, Fumika Okumura, Fumika Okumura, Tsuyoshi Nakanishi, Norio Itoh
Journal of Toxicological Sciences   40(3) 383-387   Jan 2015   [Refereed]
© 2015, Japanese Society of Toxicology. All rights reserved. Hexavalent chromium [Cr(VI)] is a carcinogenic heavy metal that is reduced to intermediate oxidation states, such as Cr(V) and Cr(IV), in the process of forming stable Cr(III) forms; it ...
Shusaku Harada, Youhei Hiromori, Youhei Hiromori, Shota Nakamura, Kazuki Kawahara, Shunsuke Fukakusa, Takahiro Maruno, Masanori Noda, Susumu Uchiyama, Kiichi Fukui, Jun Ichi Nishikawa, Hisamitsu Nagase, Yuji Kobayashi, Takuya Yoshida, Tadayasu Ohkubo, Tsuyoshi Nakanishi
Scientific Reports   5 8520   Jan 2015   [Refereed]
Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway. We recently found that TPT is a particularly strong agonist of PPA...


Tsuyoshi Nakanishi, Jun Ichi Nishikawa
Ecotoxicology of Antifouling Biocides   221-233   Dec 2009
The concept of endocrine disruption was introduced at the Work Session on Chemically Induced Alterations in Sexual Development: The Wildlife/Human Connection in 1991. At this session it was pointed out that a number of environmental chemicals affe...
Molecular targets of organotin compounds in endocrine disruption
Farumashia   42(7), 690-694    2006
Metallothionein modulates LPS-stimulated tumor necrosis factor expression in mouse peritoneal macrophages.
361, 363-369    2002
J. Clin. Endocrinol. & Metab., 87(6), 2830-2837   87(6), 2830-2837    2002
Metallothionein modulates LPS-stimulated tumor necrosis factor expression in mouse peritoneal macrophages.
361, 363-369/,    2002

Books etc

Ecotoxicology of Antifouling Biocides
Tsuyoshi Nakanishi, Jun-ichi Nishikawa (Part:Contributor, Genetic impacts of organotin compounds)
Springer, Tokyo   2009   ISBN:978-4-431-85709-9

Conference Activities & Talks

Tsuyoshi Nakanishi
15 Dec 2018   Japan Society of Endocrine Disrupters Research
Tsuyoshi Nakanishi
The 7th International Congress of Asian Society of Toxicology (ASIATOX2015)   24 Jun 2015   Asian Society of Toxicology
Tsuyoshi Nakanishi
The First Congress of the International Federation of Apitherapy and the VII-th.of the Romanian Apitherapy Society   27 Oct 2014   Romanian Apitherapy Society
Tsuyoshi Nakanishi
The INTERNATIONAL SOCIETY FOR TRACE ELEMENT RESEARCH IN HUMANS 2013   19 Nov 2013   International Society for Trace Element Research in Humans
Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor [Invited]
Tsuyoshi Nakanishi
The 5th International Conference on Metals and Genetics   6 Sep 2011   

Research Grants & Projects

High throughput identification technologies of toxic chemicals for protecting the safety of drinking water
Japan Science and Technology Agency: Strategic International Collaborative Research Program, Based on intergovernmental agreements on science and technology cooperation
Project Year: Aug 2016 - Mar 2019    Investigator(s): Tsuyoshi Nakanishi
Effects of excessive estrogen exposure during the prenatal period on sexual development in mice
Ministry of the Environment Government of Japan: ExTEND2005
Project Year: Apr 2006 - Mar 2010    Investigator(s): Tsuyoshi Nakanishi
Construction of new environmental risk assessment methods based on modified nuclear receptors
New Energy and Industrial Technology Development Organization: Industrial Technology Research Grant Program
Project Year: Sep 2007 - Aug 2009    Investigator(s): Tsuyoshi Nakanishi
Ministry of Health, Labour and Welfare: Health and Labor Sciences Research Grants
Project Year: Sep 2002 - Mar 2005    Investigator(s): Tsuyoshi Nakanishi
Establishment of the evaluation method of placental toxicity by endocrine disrupters
New Energy and Industrial Technology Development Organization: Industrial Technology Research Grant Program
Project Year: Sep 2001 - Mar 2003    Investigator(s): Tsuyoshi Nakanishi
Physio Logical role of endogenous.metallothionein in immune system.
Drug Delivery System for vaccines using liposomes.
Effects of endocrine disruptors on placental functions