Masahito Ikawa

Profile Information

Affiliation: Professor, Research Institute for Microbial Diseases, Osaka University
: Program Appointed Professor, The Institute of Medical Science, The University of Tokyo

Degree: Ph.D(Osaka University)

Researcher number: 20304066
J-GLOBAL ID: 200901098959178753
researchmap Member ID: 1000245631

External link: http://www.dma.jim.osaka-u.ac.jp/view?l=en&u=867

Research Interests

Research Areas

Research History

Aug, 2016 - Present

The Institute of Medical Science, The University of Tokyo
Nov, 2012 - Present

Professor, Osaka University
Apr, 2004 - Oct, 2012

Associate Professor, Osaka University
Jul, 1998 - Mar, 2004

Assistant Professor, Osaka University
Sep, 2000 - Sep, 2002

Research Associate, Salk Institute
Apr, 1997 - Jun, 1998

Research Fellow, JSPS
Apr, 1994 - Mar, 1997

日本学術振興会特別研究員(DC)

Education

Apr, 1994 - Mar, 1997

Graduate School of Pharmaceutical Sciences, Osaka University
- Mar, 1992

Faculty of Pharmaceutical Science, Osaka University

Major Awards

May, 2021

令和3年度安東・田嶋賞, 日本実験動物学会

伊川正人
Jul, 2017

SSR Research Award, Society for the Study of Reproduction

IKAWA Masahito
Jul, 2014

総長顕彰研究部門, 大阪大学

伊川正人
Feb, 2013

JSPS PRIZE, Japan Society for the Promotion of Science

Masahito Ikawa
May, 1999

奨励賞, 日本実験動物学会

伊川正人
Jan, 1998

業績報告会・最優秀学術賞, 大阪大学・微生物病研究所

伊川正人

Major Papers

442

Human sperm TMEM95 binds eggs and facilitates membrane fusion.

Shaogeng Tang, Yonggang Lu, Will M Skinner, Mrinmoy Sanyal, Polina V Lishko, Masahito Ikawa, Peter S Kim

Proceedings of the National Academy of Sciences of the United States of America, 119(40) e2207805119, Oct 4, 2022 Peer-reviewed
RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization

Masashi Mori, Tatsuma Yao, Tappei Mishina, Hiromi Endoh, Masahito Tanaka, Nao Yonezawa, Yuta Shimamoto, Shigenobu Yonemura, Kazuo Yamagata, Tomoya S. Kitajima …

The Journal of cell biology, 220(10), Oct 4, 2021
The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization

Yoshitaka Fujihara, Sarah Herberg, Andreas Blaha, Karin Panser, Kiyonori Kobayashi, Tamara Larasati, Maria Novatchkova, Hans-Christian Theussl, Olga Olszanska, Masahito Ikawa …

Proceedings of the National Academy of Sciences of the United States of America, 118(39) e2108777118-e2108777118, Sep 28, 2021
SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice

Haruhiko Miyata, Seiya Oura, Akane Morohoshi, Keisuke Shimada, Daisuke Mashiko, Yuki Oyama, Yuki Kaneda, Takafumi Matsumura, Ferheen Abbasi, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America, 118(35), Aug 31, 2021
ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility

Keisuke Shimada, Soojin Park, Haruhiko Miyata, Zhifeng Yu, Akane Morohoshi, Seiya Oura, Martin M. Matzuk, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America, 118(6), Feb 9, 2021
Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility

Chunyu Liu, Haruhiko Miyata, Yang Gao, Yanwei Sha, Shuyan Tang, Zoulan Xu, Marjorie Whitfield, Catherine Patrat, Huan Wu, Emmanuel Dulioust …

American Journal of Human Genetics, 107(2) 330-341, Aug 6, 2020 Peer-reviewed
NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility

Daiji Kiyozumi, Taichi Noda, Ryo Yamaguchi, Tomohiro Tobita, Takafumi Matsumura, Kentaro Shimada, Mayo Kodani, Takashi Kohda, Yoshitaka Fujihara, Manabu Ozawa …

Science, 368(6495) 1132-1135, Jun 5, 2020 Peer-reviewed
Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice

Taichi Noda, Yonggang Lu, Yoshitaka Fujihara, Seiya Oura, Takayuki Koyano, Sumire Kobayashi, Martin M. Matzuk, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America, 117(21) 11493-11502, May 26, 2020 Peer-reviewed
Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice

Yoshitaka Fujihara, Yonggang Lu, Taichi Noda, Asami Oji, Tamara Larasati, Kanako Kojima-Kita, Zhifeng Yu, Ryan M. Matzuk, Martin M. Matzuk, Masahito Ikawa

Proceedings of the National Academy of Sciences of the United States of America, 117(17) 9393-9400, Apr, 2020 Peer-reviewed
Identification of multiple male reproductive tractspecific proteins that regulate sperm migration through the oviduct in mice

Yoshitaka Fujihara, Taichi Noda, Kiyonori Kobayashi, Asami Oji, Sumire Kobayashi, Takafumi Matsumura, Tamara Larasati, Seiya Oura, Kanako Kojima-Kita, Zhifeng Yu …

Proceedings of the National Academy of Sciences of the United States of America, 116(37) 18498-18506, Sep 10, 2019 Peer-reviewed
TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa

Julio M. Castaneda, Rong Hua, Haruhiko Miyata, Asami Oji, Yueshuai Guo, Yiwei Cheng, Tao Zhou, Xuejiang Guo, Yiqiang Cui, Bin Shen …

Proceedings of the National Academy of Sciences of the United States of America, 114(27) E5370-E5378, Jul 3, 2017 Peer-reviewed
Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice

Haruhiko Miyata, Julio M. Castaneda, Yoshitaka Fujihara, Zhifeng Yu, Denise R. Archambeault, Ayako Isotani, Daiji Kiyozumi, Maya L. Kriseman, Daisuke Mashiko, Takafumi Matsumura …

Proceedings of the National Academy of Sciences of the United States of America, 113(28) 7704-7710, Jul 12, 2016 Peer-reviewed
Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive

Haruhiko Miyata, Yuhkoh Satouh, Daisuke Mashiko, Masanaga Muto, Kaori Nozawa, Kogiku Shiba, Yoshitaka Fujihara, Ayako Isotani, Kazuo Inaba, Masahito Ikawa

Science, 350(6259) 442-445, Oct 23, 2015 Peer-reviewed
Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa

Yoshitaka Fujihara, Keizo Tokuhiro, Yuko Muro, Gen Kondoh, Yoshihiko Araki, Masahito Ikawa, Masaru Okabe

Proceedings of the National Academy of Sciences of the United States of America, 110(20) 8111-8116, May 14, 2013 Peer-reviewed
MiR-200b and miR-429 function in mouse ovulation and are essential for female fertility

Hidetoshi Hasuwa, Jun Ueda, Masahito Ikawa, Masaru Okabe

Science, 341(6141) 71-73, 2013 Peer-reviewed
Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility

Keizo Tokuhiro, Masahito Ikawa, Adam M. Benham, Masaru Okabe

Proceedings of the National Academy of Sciences of the United States of America, 109(10) 3850-3855, Mar 6, 2012 Peer-reviewed
Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

Keiichi Kumasawa, Masahito Ikawa, Hiroyasu Kidoya, Hidetoshi Hasuwa, Tomoko Saito-Fujita, Yuka Morioka, Nobuyuki Takakura, Tadashi Kimura, Masaru Okabe

Proceedings of the National Academy of Sciences of the United States of America, 108(4) 1451-1455, Jan, 2011 Peer-reviewedLead authorCorresponding author
Fertilization: A sperm's journey to and interaction with the oocyte

Masahito Ikawa, Naokazu Inoue, Adam M. Benham, Masaru Okabe

Journal of Clinical Investigation, 120(4) 984-994, Apr, 2010 Peer-reviewedInvited
Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer

Yuka Okada, Yuko Ueshin, Ayako Isotani, Tomoko Saito-Fujita, Hisako Nakashima, Kazushi Kimura, Akira Mizoguchi, Masatsugu Oh-Hora, Yoshiko Mori, Masato Ogata …

Nature Biotechnology, 25(2) 233-237, Feb, 2007 Peer-reviewed
Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells

Mito Kanatsu-Shinohara, Masahito Ikawa, Masanori Takehashi, Narumi Ogonuki, Hiromi Miki, Kimiko Inoue, Yasuhiro Kazuki, Jiyoung Lee, Shinya Toyokuni, Mitsuo Oshimura …

Proceedings of the National Academy of Sciences of the United States of America, 103(21) 8018-8023, May 23, 2006 Peer-reviewed
The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

Naokazu Inoue, Masahito Ikawa, Ayako Isotani, Masaru Okabe

Nature, 434(7030) 234-238, Mar 10, 2005 Peer-reviewed
A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA

Gustavo Tiscornia, Oded Singer, Masahito Ikawa, Inder M. Verma

Proceedings of the National Academy of Sciences of the United States of America, 100(4) 1844-1848, Feb 18, 2003 Peer-reviewed
Restoration of spermatogenesis by lentiviral gene transfer: Offspring from infertile mice

Masahito Ikawa, Vinay Tergaonkar, Atsuo Ogura, Narumi Ogonuki, Kimiko Inoue, Inder M. Verma

Proceedings of the National Academy of Sciences of the United States of America, 99(11) 7524-7529, May 28, 2002 Peer-reviewed
Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

Alexander Pfeifer, Masahito Ikawa, Yelena Dayn, Inder M. Verma

Proceedings of the National Academy of Sciences of the United States of America, 99(4) 2140-2145, Feb 19, 2002 Peer-reviewed
The putative chaperone calmegin is required for sperm fertility

Masahito Ikawa, Ikuo Wada, Katsuya Kominami, Daisuke Watanabe, Kiyotaka Toshimori, Yoshitake Nishimune, Masaru Okabe

Nature, 387(6633) 607-610, Jun 5, 1997 Peer-reviewed