Background: Smoking and obesity are leading global causes of death. The aim of the present study was to develop a test to detect early lung abnormalities caused by smoking and/or obesity- and to elucidate the underlying mechanisms and major contributors,, factors.
Methods: One hundred twenty-nine healthy, adults, 20 to 40 years of age, with normal spirometry findings, were divided into the following five groups: 38 healthy, subjects (15 female subjects); 46 smokers (5 female smokers);.18 overweight nonsmokers (2 female nonsmokers; normal body mass index [BMI], >= 25 kg/m(2); ran e, 25.0 to 37.2 kg/m(2)); 19 overweight smokers (I female smoker; BMI range, 25.2 to 33.5 kg/m(2),); and 8 ex-smokers (BMI range, 20.8 to 24.1 kg/m(2)). A modified pulse oximeter was employed for measuring the fall in pulse oximetric saturation caused by 20-s breath-holding (dSpo(2)). at resting end expiration in the sitting posture Results: In healthy subjects, dSpo(2) had no significant correlation with age (p = 0.66). In smokers, dSpo(2) correlated with both the number of pack-years W = 0.590; 13 < 0.001) and closing volume (CV)/,vital capacity (VC) ratio (r(2) = 0.573; p < 0.001). In overweight nonsmokers, dSp(2), increased significantly with BMI alone (r(2) = 0.667; p < 0.001). In overweight smokers, the largest increase in the mean dSpo(2) was observed. Multiple linear regression analysis Suggested that BMI and CV/VC are the two major contributing factors determining dSpo(2) during breath-holding. In young former smokers, no significant increase in the mean dSpo(2) was observed (p = 0.77) a mean (+/- SD) duration of 5.2 +/- 2.9 years after the cessation of smoking. No significant difference in dSpo(2) was observed between men and women.
Conclusions: A new test that measures oxygen saturation during breath-holding reveals early lung abnormalities in subjects who other smoke or are overweight, especially if these factors are combined. Peripheral airway, abnormalaties ties and/or lung volume reduction may play roles in the greater desaturation. (CHEST 2009; 136:545-553)