2012年7月
Relationship between structure and antiproliferative activity of 1-azaflavanones
Anticancer Research
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- 巻
- 32
- 号
- 7
- 開始ページ
- 2819
- 終了ページ
- 2825
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
The synthesis of 19 derivatives of 2-phenyl-3,4-dihydroquinolin-4(1H)-one, as aza analogs of flavanones, was carried out and these compounds were further screened for their antiproliferative activity toward HL60 promyelocytic leukemia cells. In comparison with flavanone the replacement of C-ring ether oxygen atom with a nitrogen atom potentiated activity by more than 100-fold. It was suggested that the aromaticity of the B-ring contributes greatly to the activity of 1-azaflavanones.
- リンク情報
- ID情報
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- ISSN : 0250-7005
- PubMed ID : 22753743
- SCOPUS ID : 84865685383