荘司 佳奈子

Abstract Introduction: Osteoprogenitors play an essential role in the regeneration process that leads to the successful integration of dental implants. However, it is unclear how systemic osteoporosis affects osteoprogenitors in oral bone. The present study was designed to determine the short-term effects of ovariectomy (OVX) on osteoprogenitors derived from the healing extraction socket of the mandibular incisor of the rat.Methods: Six-month-old rats were ovariectomized (n=8) and control rats were left intact (n=8). 2 weeks post-OVX, the right mandibular incisor was extracted. 4 weeks post-extraction, basal mandibular bone between the 1st and 3rd molar in the healing extraction socket was used to determine the number of fibroblastic progenitors (CFU-F), alkaline phosphatase-positive fibroblastic progenitors (AP-positive CFU-F), Dex-dependent osteoprogenitors (CFU-O Dex) and Prog-dependent osteoprogenitors (CFU-O Prog) using colony assay (n=5). Osteocalcin mRNA expression was evaluated using in situ hybridization (n=3). Data were statistically analyzed using two-way ANOVA or Studentユs t-test. Results: OVX did not affect the number of CFU-O and CFU-F in any of the treatment groups.

インプラントを高齢者に施す場合を想定し、骨粗鬆症が下顎の骨芽細胞の増殖・分化に与える影響について検討した。

閉経後の女性に対するインプラント治療を想定し、骨粗鬆症が骨芽細胞の分化・増殖に与える影響に関して検討した。

骨粗鬆症の下顎骨骨代謝に与える影響に関する基礎的研究