山下年晴 (Toshiharu YAMASHITA) - マイポータル

基本情報

所属: 筑波大学医学医療系助教

学位: 博士（理学）(2003年4月東北大学)

連絡先: t-yamamd.tsukuba.ac.jp
J-GLOBAL ID: 200901048974802296
researchmap会員ID: 1000248746

研究分野

ライフサイエンス / 分子生物学 /

経歴

2003年4月 - 2005年3月

科学技術振興機構, 研究員

学歴

- 2003年

東北大学大学院, 理学研究科, 化学専攻
- 1996年

東北大学, 理学部, 化学科

委員歴

2024年4月 - 現在

HBP入試委員
2017年2月 - 現在

研究管理指導員

論文

SARS-CoV-2 nucleocapsid protein induced non-small cell lung cancer malignancy via TLR4/HIF-1a signaling pathway

Lomanto, M, Y. Widjaja, Vuong, C-K., Yamashita, T., Ohneda, O.

ANNALS OF ONCOLOGY 36(SI) 2025年9月
Characterization and neurogenic responses of primary and immortalized M$00FCller glia

Tran, Thi-Hang, Lukmanto, Donny, Chen, Mei, Strauss, Olaf, Yamashita, Toshiharu, Ohneda, Osamu, Fukuda, Shinichi

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 13 2025年5月査読有り
Mesenchymal stem cell-derived extracellular vesicles reduce inflammatory responses to SARS-CoV-2 and Influenza viral proteins via miR-146a/NF-κB pathway

Anggraeni, Neni, Vuong, Cat-Khanh, Silvia, Precella, Fukushige, Mizuho, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Ohneda, Osamu

SCIENTIFIC REPORTS 14(1) 2024年11月査読有り
Extracellular Vesicles Derived from Type 2 Diabetic Mesenchymal Stem Cells Induce Endothelial Mesenchymal Transition under High Glucose Conditions Through the TGFβ/Smad3 Signaling Pathway

Vuong, Cat-Khanh, Fukushige, Mizuho, Ngo, Nhat-Hoang, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo, Tsukada, Toru, Hiramatsu, Yuji, Ohneda, Osamu

Stem cells and development 33(11-12) 262-275 2024年6月
SARS-CoV-2 M-protein promotes malignancy of breast cancer cells and alters interaction in breast tumor microenvironment

Nguyen, T. H. N., Usuda, M., Park, S., Vuong, C. K., Yamashita, T., Ohneda, O.

EUROPEAN JOURNAL OF CANCER 200(1) 92-93 2024年3月
Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression

Nguyen, Hoai-Nga Thi, Vuong, Cat-Khanh, Fukushige, Mizuho, Usuda, Momoko, Takagi, Liora Kaho, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo …

FRONTIERS IN ONCOLOGY 14 2024年3月査読有り
Impairment of HIF-2α Expression Induced the Compensatory Overexpression of the HIF-1α/SDF-1 Axis to Promote Wound Healing

Yamashita, Toshiharu, Vuong, Cat-Khanh, Ngo, Nhat-Hoang, Osaka, Motoo, Hiramatsu, Yuji, Ohneda, Osamu

STEM CELLS AND DEVELOPMENT 32(19-20) 592-605 2023年10月査読有り
Transformed extracellular vesicles with high angiogenic ability as therapeutics of distal ischemic tissues

Vuong Cat, Khanh, Ngo, Nhat-Hoang, Chang, Yun-Hsuan, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo, Hiramatsu, Yuji, Ohneda, Osamu

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10 2022年8月査読有り責任著者
Extracellular vesicles derived from Wharton's Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway

Chang, Yun-Hsuan, Vuong, Cat-Khanh, Ngo, Nhat-Hoang, Yamashita, Toshiharu, Ye, Xiucai, Futamura, Yasunori, Fukushige, Mizuho, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo …

Scientific reports 12(1) 13550-13550 2022年8月
Type 2 Diabetes Mellitus Promotes the Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells into Cancer-Associated Fibroblasts, Induced by Breast Cancer Cells

Chang, Yun-Hsuan, Ngo, Nhat-Hoang, Khanh, Vuong Ca, Yamashita, Toshiharu, Osaka, Motoo, Hiramatsu, Yuji, Ohneda, Osamu

STEM CELLS AND DEVELOPMENT 31(21-22) 659-671 2022年7月査読有り
Label-free metabolic imaging of non-alcoholic-fatty-liver-disease (NAFLD) liver by volumetric dynamic optical coherence tomography

Mukherjee, Pradipta, Fukuda, Shinichi, Lukmanto, Donny, Yamashita, Toshiharu, Okada, Kosuke, Makita, Shuichi, Abd El-Sadek, Ibrahim, Miyazawa, Arata, Zhu, Lida, Morishita, Rion …

BIOMEDICAL OPTICS EXPRESS 13(7) 4071-4086 2022年7月査読有り
SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells.

Nguyen, Hoai-Nga Thi, Kawahara, Marie, Khanh, Vuong Ca, Fukushige, Mizuho, Yamashita, Toshiharu, Ohneda, Osamu

FRONTIERS IN ONCOLOGY 12 2022年6月査読有り
Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy.

P, Mukherjee, S, Fukuda, D, Lukmanto, T, Yamashita, K, Okada, S, Makita, IA, El-Sadek, A, Miyazawa, Zhu L, Oshika T …

Proc SPIE 11972 2022年3月査読有り
Multi-functional optical coherence microscopy for in-vitro and ex-vivo tissue investigation

Yasuno, Yoshiaki, Abd El-Sadek, Ibrahim, Miyazawa, Arata, Shen, Larina Tzu-Wei, Seesan, Thitiya, Zhu, Lida, Oida, Daisuke, Oikawa, Kensuke, Makita, Shuichi …

Proceedings Volume 11924, Optical Coherence Imaging Techniques and Imaging in Scattering Media IV 2021年12月査読有り
Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography

Okada, Kosuke, Mukherjee, Pradipta, Miyazawa, Arata, Fukuda, Shinichi, Yamashita, Toshiharu, Lukmanto, Donny, Okada, Kosuke, El‐Sadek, Ibrahim Abd, Zhu, Lida …

Sci Rep. 11(1) 20054-20054 2021年10月査読有り
Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin Conditions

Khanh, Vuong Ca, Fukushige, Mizuho, Chang, Yun-Hsuan, Hoang, Ngo Nha, Yamashita, Toshiharu, Obata-Yasuoka, Mana, Hamada, Hiromi, Osaka, Motoo, Hiramatsu, Yuji, Ohneda, Osamu

Stem Cells and Development 30(15) 758-772 2021年8月査読有り
Volumetric multi-contrast dynamics imaging for ex vivo liver microvasculature activity visualization using Jones matrix optical coherence tomography

Mukherjee, P, Miyazawa, A, Shen, L. T. W, Fukuda, S, Yamashita, T, Oka, Y, El-Sadek, I. G. Ab, Makita, S, Matsusaka, S …

Proc. SPIE 2021年3月査読有り
Optical coherence tomography- based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids

Abd El-Sadek, Ibrahim, Miyazawa, Arata, Shen, Larina Tzu-Wei, Makita, Shuichi, Fukuda, Shinichi, Yamashita, Toshiharu, Oka, Yuki, Mukherjee, Pradipta, Matsusaka, Satoshi …

BIOMEDICAL OPTICS EXPRESS 11(11) 6231-6248 2020年11月査読有り
Type 2 diabetes mellitus induced paracrine effects on breast cancer metastasis via extracellular vesicles derived from human mesenchymal stem cells

Khanh, Vuong Ca, Fukushige, Mizuho, Moriguchi, Kana, Yamashita, Toshiharu, Osaka, Motoo, Hiramatsu, Yuji, Ohneda, Osamu

Stem Cells and Development 29(21) 1382-1394 2020年9月査読有り
Quantification of Ex Vivo Tissue Activity by Short and Long Time-Course Analysis of Multifunctional OCT Signals

Ibrahim, Abd El-Sadek, Arata, Miyazawa, Larina, Shen, Fukuda, Shinichi, Yamashita, Toshiharu, Oka, Yuki, Pradipta, Mukherjee, Makita, Shuichi, Matsusaka, Satoshi …

Proc. SPIE 11228 112282C 2020年2月

もっとみる

書籍等出版物

HIFのin vivoモデルによる機能解析

山下年晴, 大根田修 (担当:監修)

実験医学羊土社 2007年9月
環境応答系転写因子の分子機構の解明

山下年晴, 山本, 雅之 (担当:監修)

化学工業 2003年1月

講演・口頭発表等

Extracellular Vesicles Derived from Wharton’s Jelly Mesenchymal Stem Cells Inhibit the Tumor Environment

Ariani, Patricia Rika, Chang, Yun-Hsuan, Vuong, oshiharu, Yamashita, Ohneda

The International Conference on Biomedical Science VNUK 2024
Protective effects of young sources mesenchymal stem cell-derived extracellular vesicles on ultra-violet-exposed skin cells

Ngo, Nhat Hoang, Vuong, Yamashita, Toshiharu, Ohneda

International Society for Stem Cell Research Annual Conference 2024
Renal tubular structure and metabolism revealed by dynamic optical coherence tomography and OCT angiography

Mukherjee, Pradipta, Fukuda, Shinichi, Lukmanto, Donny, Yamashita, Toshiharu, Okada, Kosuke, Makita, Shuichi, El-Sadek, Ibrahim G. Abd, Lim, Yiheng, Yasuno, Yoshiaki

Dynamics and Fluctuations in Biomedical Photonics XX, Photonics West BiOS SPIE
Revealing renal tubular structural metabolism without labeling by functional optical coherence tomography

Mukherjee, Pradipta, Fukuda, Shinichi, Lukmanto, Donny, Yamashita, Toshiharu, Okada, Kosuke, Makita, Shuichi, El-Sadek, Ibrahim Abd, Lim, Yiheng, Yasuno, Yoshiaki

Optics & Photonics Japan 2022 日本光学会
Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1α signaling pathway

Yun-Hsuan, Chang, Vuong, Cat Khanh, Toshiharu, Yamashita, Osamu, Ohneda

Tsukuba Global Science Week 2022 2022年9月30日
Nicotine and SARS-CoV-2 Protein Induce the Malignancy of Lung Cancer Cell. International Student Presentations of Medical and Life Sciences Session.

Lomanto, Markus Yovian Widjaja, Nguyen, Hoai-Nga Thi, Khanh, Vuong Ca, Yamashita, Toshiharu, Ohneda, Osamu

Tsukuba Global Science Week 2022 2022年9月29日
SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells

Nguyen, Hoai-Nga Thi, Khanh, Vuong Ca, Yamashita, Toshiharu, Ohneda, Osamu

Tsukuba Global Science Week 2022 2022年9月29日
Transformed Extracellular Vesicles with High Angiogenic Ability as Therapeutics of Distal Ischemic Tissues

Ngo, Nhat-Hoang, Khanh, Vuong Ca, Yamashita, Toshiharu, Ohneda, Osamu

Tsukuba Global Science Week 2022 2022年9月29日
Assessment of renal functional changes in obstructed nephropathy using optical coherence tomography

Mukherjee, Pradipta, Fukuda, Shinichi, Lukmanto, Donny, Yamashita, Toshiharu, Okada, Kosuke, Abd El-Sadek, Ibrahim, Miyazawa, Arata, Zhu, Lida, Makita, Shuichi, Oshika, Tetsuro, Yasuno, Yoshiaki

Optics and Photonics Japan
Multi-functional optical coherence microscopy for in-vitro and ex-vivo tissue investigation

Yasuno, Yoshiaki, El-Sadek, Ibrahim Abd, Miyazawa, Arata, Shen, Larina Tzu-Wei, Seesan, Thitiya, Zhu, Lida, Oida, Daisuke, Oikawa, Kensuke, Makita, Shuichi, Fukuda, Shinichi, Yamashita, Toshiharu, Mukherjee, Pradipta, Oshika, Tetsuro, Branasiri, Prathan, Matsusaka, Satoshi

European Conference on Biomedical Optics
Three-dimensional imaging of mouse liver dynamics by polarization-sensitive optical coherence tomography

Mukherjee, Pradipta, Miyazawa, Arata, Fukuda, Shinichi, Yamashita, Toshiharu, El-Sadek, Ibrahim Abd, Makita, Shuichi, Oshika, Tetsuro, Yasuno, Yoshiaki

Label-free Biomedical Imaging and Sensing (LBIS) 2021, Photonics West BiOS SPIE
Volumetric multi-contrast dynamics imaging for ex vivo liver microvasculature activity visualization using Jones matrix optical coherence tomography

Mukherjee, Pradipta, Miyazawa, Arata, Shen, L. T. W, Fukuda, S, Yamashita, T, Oka, Yuki, El-Sadek, I. G. Abd, Makita, Shuichi, Matsusaka, S, Oshika, T, Kano, Hideaki, Yasuno, Yoshiaki

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, Photonics West BiOS SPIE
3D label-free dynamics imaging of liver microvasculature by optical coherence microscopy

Mukherjee, Pradipta, Miyazawa, Arata, Fukuda, Shinichi, Yamashita, Toshiharu, El-Sadek, brahim Abd, Makita, Shuichi, Oshika, Tetsuro, Yasuno, Yoshiaki

Optics & Photonics Japan 2020 日本光学会
Quantification of ex-vivo tissue activity by polarization dynamics imaging using Jones matrix optical coherence tomography

Mukherjee, Pradipta, Miyazawa, Arata, Shen, Larina, Fukuda, Shinichi, Yamashita, Toshiharu, Oka, Yuki, Abd El-Sadek, Ibrahim, Makita, Shuichi, Matsusaka, Satoshi, Oshika, Tetsuro, Kano, Hideaki, Yasuno, Yoshiaki

Biomedical Imaging and Sensing Conference 2020 2020年8月24日
Effect of soy protein intake on weak bones by the food restriction in young female rats

Y, Aikawa, T, Narukawa, K, Kioka, T, Yamashita, N, Sasai, M, Ohtsuki, 麻見, 直美

Human High Performance International Forum 2020 2020年2月17日 ARIHHPセンター
Quantification of ex vivo tissue activity by short and long time-course analysis of multifunctional OCT signals

El-Sadek, Ibrahim Abd, Miyazawa, Arata, Shen, Larina, Fukuda, Shinichi, Yamashita,Toshiharu, Oka, Yuki, Mukherjee, Pradipta, Makita, Shuichi, Matsusaka, Satoshi, Oshika, Tetsuro, Kano, Hideaki, Yasuno, Yoshiaki

SPIE Photonics West/ BiOS 2020
Quantification of ex vivo tissue activity by short and long timecourse analysis of multifunctional OCT signals

El-Sadek, Ibrahim Abd, Miyazawa, Arata, Shen, Larina, Fukuda, Shinichi, Yamashita,Toshiharu, Oka, Yuki, Mukherjee, Pradipta, Makita, Shuichi, Matsusaka, Satoshi, Oshika, Tetsuro, Kano, Hideaki, Yasuno, Yoshiaki

SPIE Photonics West/ BiOS 2020 2020年2月1日
Virtual multi-directional optical coherence tomography

El-Sadek, Ibrahim Abd, Miyazawa, Arata, Shen, Larina, Fukuda, Shinichi, Yamashita,Toshiharu, Oka, Yuki, Mukherjee, Pradipta, Makita, Shuichi, Matsusaka, Satoshi, Oshika, Tetsuro, Kano, Hideaki, Yasuno, Yoshiaki

SPIE Photonics West/ BiOS 2020 SPIE
Impairment of Sirt1 plays the key role in the dysfunction of mesenchymal stem cells in beige adipogenesis

Vuong Cat, Khanh, Yamashita, Toshiharu, Ohneda, Osamu

The Joint Young Research Meeting in Biomedical Science 2020年1月10日
Study the effects of type 2 diabetes mellitus on functions of Wharton jelly's Mesenchymal stem cells for the treatment of diabetic foot ulcer

Sipayung, Shinta Masyta, Khanh, Vuong Ca, Yamashita, Toshiharu, Ohneda, Osamu

The Joint Young Research Meeting in Biomedical Science 2020年1月10日

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

膠芽腫の血管co-option・mimicry・低酸素領域の分子機構と標的治療

日本学術振興会基盤研究(B) 基盤研究(C) 2018年 - 2020年

高野晋吾
新規bHLH/PAS因子の低酸素応答

（選択しない） 2005年 - 2007年

山下年晴