Wettability control and bonding of fluoropolymers are important in the microfabrication of microfluidic devices. Here, we demonstrate a process that combines a unique plasma surface modification with surfactant. We employed a tetrafluoro-ethylene-hexafluoropropylene copolymer (PFA) plate dipped into a surfactant solution and briefly exposed to oxygen plasma. We discovered that the contact angle of water on a PFA plate depends on volatility of the surfactant. With this treatment, direct bonding between the PFA plates occurred under low temperature conditions. Finally, we demonstrated the micropatterning of the plate with a shadow mask.