2007年
Anti- and proinflammatory effects of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) on human eosinophil functions
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
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- 巻
- 143
- 号
- 開始ページ
- 15
- 終了ページ
- 22
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1159/000101399
- 出版者・発行元
- KARGER
The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is recognized as a potent lipid mediator that is derived from PGD(2), which is produced abundantly in allergic inflammatory sites. It is now established that 15d-PGJ(2) negatively regulates cellular functions through its intracellular targets such as peroxisome proliferator-activated receptor-gamma (PPAR gamma). However, recent studies revealed that 15d-PGJ(2) appears to possess not only anti-inflammatory activities but also a proinflammatory potential depending on its concentration and the activation state of the target cell. For instance, at low concentrations, 15d-PGJ(2) enhances eotaxin-induced chemotaxis, shape change, and actin reorganization in eosinophils through its ligation with PPAR gamma. Moreover, 15d-PGJ(2) itself is a potent chemoattractant, and it induces calcium mobilization, and up-regulates CD11b expression through its membrane receptor - chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). Conversely, at high concentrations, 15d-PGJ(2) inhibits eosinophil survival by inducing apoptosis in a PPAR gamma-independent manner. Here, we discuss the pathophysiological roles of 15d-PGJ(2) that could act as a paracrine, autocrine, and intracrine substance to regulate eosinophil functions. Copyright (C) 2007 S. Karger AG, Basel.
- リンク情報
- ID情報
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- DOI : 10.1159/000101399
- ISSN : 1018-2438
- Web of Science ID : WOS:000247527500003