2007年
Possible novel receptor for PGD(2) on human bronchial epithelial cells
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- 巻
- 143
- 号
- 開始ページ
- 23
- 終了ページ
- 27
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1159/000101400
- 出版者・発行元
- KARGER
Prostaglandin D-2 (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. Recent studies have shown that PGD(2) exerts its effects through two different G-protein-coupled receptors (GPCRs), the D-prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper type-2 cells (CRTH2), expressed in various human tissues. The PGD(2)/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of allergic inflammation. We have reported that normal human bronchial epithelial cells (NHBE) and epithelial cell lines (NCI-H-292) expressed CRTH2, and PGD(2) induces production of IL-8 and GM-CSF. This review discusses the role of CRTH2/DP on epithelial cells and mentions a possible novel receptor for PGD(2). Copyright (C) 2007 S. Karger AG, Basel.
- リンク情報
- ID情報
-
- DOI : 10.1159/000101400
- ISSN : 1018-2438
- Web of Science ID : WOS:000247527500004