MISC

2007年

Possible novel receptor for PGD(2) on human bronchial epithelial cells

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
  • Takahito Chiba
  • Akira Kanda
  • Shigeharu Ueki
  • Wataru Ito
  • Kazutoshi Yamaguchi
  • Yumiko Kamada
  • Masahide Takeda
  • Tomomi Tanigai
  • Hajime Oyamada
  • Hiroyuki Kayaba
  • Junichi Chihara
  • 全て表示

143
開始ページ
23
終了ページ
27
記述言語
英語
掲載種別
DOI
10.1159/000101400
出版者・発行元
KARGER

Prostaglandin D-2 (PGD(2)), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. Recent studies have shown that PGD(2) exerts its effects through two different G-protein-coupled receptors (GPCRs), the D-prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper type-2 cells (CRTH2), expressed in various human tissues. The PGD(2)/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of allergic inflammation. We have reported that normal human bronchial epithelial cells (NHBE) and epithelial cell lines (NCI-H-292) expressed CRTH2, and PGD(2) induces production of IL-8 and GM-CSF. This review discusses the role of CRTH2/DP on epithelial cells and mentions a possible novel receptor for PGD(2). Copyright (C) 2007 S. Karger AG, Basel.

リンク情報
DOI
https://doi.org/10.1159/000101400
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000247527500004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1159/000101400
  • ISSN : 1018-2438
  • Web of Science ID : WOS:000247527500004

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