2008年11月
EG2 expressed by eosinophils as a clinically useful indicator of asthma
ALLERGY AND ASTHMA PROCEEDINGS
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- 巻
- 29
- 号
- 6
- 開始ページ
- 609
- 終了ページ
- 613
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.2500/aap.2008.29.3171
- 出版者・発行元
- OCEAN SIDE PUBLICATIONS INC
The monitoring of airway inflammation is mandatory for the improved control of bronchial asthma. We previously reported that intracellular EG2 levels of eosinophils, a marker of bronchial asthma increased in asthma patients. In this study, we hypothesized that eosinophil EG2(+) expression increases during airway inflammation in asthmatic individuals. Eosinophil EG2(+) and percentage eosinophil EG2(+) with whole blood flow cytometry counts, serum total IgE, serum eosinophil cationic protein, eosinophil-derived neurotoxin, and percent of forced expiratory volume in 1 second/force vital capacity (FEV(1)/FVC) were measured in 33 asthmatic patients and 22 healthy volunteers. The relationships between these markers were evaluated. Comparisons were made on EG2(+) expression between attack and asymptomatic periods in six asthmatic patients. EG2(+) expression was significantly greater in the asthmatic patients than it? healthy subjects. Furthermore, the EG2(+) expression showed a significant increase during attacks. EG2(+) expression inversely correlated with the FEV(1)/FVC. These results suggest that EG2(+) expression may be a useful clinical marker of airway inflammation in asthma.
- リンク情報
- ID情報
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- DOI : 10.2500/aap.2008.29.3171
- ISSN : 1088-5412
- Web of Science ID : WOS:000262026200008