1994年9月
EXPRESSION OF NEURONAL SRC MESSENGER-RNA AS A FAVORABLE MARKER AND INVERSE CORRELATION TO N-MYC GENE AMPLIFICATION IN HUMAN NEUROBLASTOMAS
INTERNATIONAL JOURNAL OF CANCER
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- 巻
- 58
- 号
- 6
- 開始ページ
- 793
- 終了ページ
- 798
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1002/ijc.2910580607
- 出版者・発行元
- WILEY-LISS
Neuron-specific src mRNA, which is expressed in human brain tissue by alternative splicing, is associated with neural differentiation. Neuronal c-srcNI expression may be associated with the ability of neuroblastomas to mature; furthermore, c-srcN2 mRNA is induced in chemically differentiated neuroblastoma cells in vitro. The prognosis of a patient with a neuroblastoma is strongly affected by the ability of the tumor to differentiate in vivo. In order to clarify the relationship between neuronal src mRNA expression and the clinical outcome of a neuroblastoma, we analyzed the expression of src mRNA in neuroblastoma tissues from 28 patients by SI-nuclease-protection assay. N-myc gene amplification was also examined by Southern blot hybridization. The clinical significance of neuronal src mRNA expression and its relevance to N-myc gene amplification was also investigated. A high ratio (more than 10%) of c-srcN2 mRNA expression was observed in all early-stage tumors and in advanced neuroblastomas with a favorable prognosis. In contrast, in advanced neuroblastomas with an aggressive clinical phenotype, c-srcN2 mRNA expression ws found at a low ratio (below 10%). Genome amplification of the N-myc gene and expression of c-srcN2 mRNAs were inversely correlated. When combined with other prognostic markers such as N-myc gene amplification, the expression of c-srcN2 mRNA may be a new biological marker to predict the prognosis of patients with neuroblastomas.
- リンク情報
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- DOI
- https://doi.org/10.1002/ijc.2910580607
- CiNii Articles
- http://ci.nii.ac.jp/naid/80007847812
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/7523310
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994PJ01300006&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1002/ijc.2910580607
- ISSN : 0020-7136
- CiNii Articles ID : 80007847812
- PubMed ID : 7523310
- Web of Science ID : WOS:A1994PJ01300006