1995年11月
ROLLING IN P-SELECTIN DEFICIENT MICE IS REDUCED BUT NOT ELIMINATED IN THE DORSAL SKIN
BLOOD
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- 巻
- 86
- 号
- 9
- 開始ページ
- 3487
- 終了ページ
- 3492
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- W B SAUNDERS CO
P-selectin-mediated rolling is believed to be important in the recruitment of leukocytes to tissue after ischemia-reperfusion injury. The dorsal skin chamber was used to examine differences in the rolling and stable adhesion of circulating leukocytes in subcutaneous (SC) vessels of P-selectin-deficient and age-matched wild-type mice, both under basal conditions and after ischemia-reperfusion. Rolling in the postcapillary venules in SC tissue of P-selectin-deficient mice was significantly lower than that in wild-type mice under the basal conditions and post-ischemia-reperfusion (P < .05), but was not eliminated by the deletion of the P-selectin gene. No significant difference between P-selectin-deficient and wild-type mice in shear rate or leukocyte-endothelial adhesion was observed up to 24 hours after ischemia-reperfusion. These results show that P-selectin-mediated rolling is not a prerequisite for ischemia-reperfusion-induced leukocyte-endothelial adhesion in the skin. (C) 1995 by The American Society of Hematology.
- リンク情報
- ID情報
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- ISSN : 0006-4971
- Web of Science ID : WOS:A1995TB16300027