MISC

1995年11月

Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: Augmentation by erythrocytes

BIOPHYSICAL JOURNAL
  • RJ Melder
  • ,
  • LL Munn
  • ,
  • S Yamada
  • ,
  • C Ohkubo
  • ,
  • RK Jain

69
5
開始ページ
2131
終了ページ
2138
記述言語
英語
掲載種別
出版者・発行元
BIOPHYSICAL SOCIETY

The adhesive and hemodynamic forces that lead to lymphocyte rolling and arrest on activated endothelium and the biophysical role of various adhesion molecules and blood elements in this process are poorly understood. By quantifying their behavior both in vivo and in vitro, we show here that erythrocytes facilitate selectin- and integrin-mediated rolling and binding of T-lymphocytes on tumor necrosis factor alpha-activated endothelium. The relative contribution of selectins and integrins to this process can be distinguished by using a simple mathematical expression of lymphocyte capture within the range of physiological shear stress. The need for selectin participation in lymphocyte capture increases with shear stress (>1 dyn/cm(2)), and both beta 1 and beta 2 integrins act in synergy to produce adhesive drag on captured cells. These findings are potentially useful in developing strategies for intervening with T-cells in a variety of normal and pathological responses as well as for the delivery of genetically modified T-cells to their targets in vivo.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1995TV01700051&DestApp=WOS_CPL
ID情報
  • ISSN : 0006-3495
  • Web of Science ID : WOS:A1995TV01700051

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