2001年9月
Expression of amphiphysin I in sertoli cells and its implication in spermatogenesis
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- ,
- ,
- ,
- ,
- ,
- 巻
- 287
- 号
- 3
- 開始ページ
- 739
- 終了ページ
- 745
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1006/bbrc.2001.5650
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Amphiphysin I is a protein concentrated in nerve terminals and involved in the endocytosis of synaptic vesicle membrane. We show here that amphiphysin I is expressed in the rat testis, localized exclusively in the Sertoli cells. In the postnatal testicular development, expression of amphiphysin I was not evident at birth, but became significant at postnatal day 15 (P15), coinciding with the onset of spermatogenesis. The expression level of amphiphysin I increased 10-fold between P15 and P25 to reach the adult level. In adult testes reversibly damaged by ethane dimethane sulphonate administration, expression of amphiphysin I did not change following the damage, whereas the protein was transiently converted into its phosphorylated form. The increase in levels of phosphorylated amphiphysin I was closely associated with the severe histological damage to germ cells. The present findings suggest that amphiphysin I in Sertoli cells is involved in spermatogenesis, probably through endocytic processes. (C) 2001 Academic Press.
- リンク情報
- ID情報
-
- DOI : 10.1006/bbrc.2001.5650
- ISSN : 0006-291X
- Web of Science ID : WOS:000171400200024