1995年1月
DIRECT ANTITUMOR EFFECT OF CEPHARANTHIN AND COMBINED EFFECT WITH ADRIAMYCIN AGAINST EHRLICH ASCITES TUMOR IN MICE
ANTICANCER RESEARCH
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- 巻
- 15
- 号
- 1
- 開始ページ
- 67
- 終了ページ
- 70
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- INT INST ANTICANCER RESEARCH
Direct antitumor effect of cepharanthin (CEP) and the combined effect with adriamycin (ADR), as well as the effect of CEP against body weight loss caused by treatment of ADR were evaluated using ICR mice bearing Ehrlich ascites tumor. Single administration of CEP reduced tumor growth compared to that of the untreated control but not significantly. However, multiple administration of CEP reduced the tumor growth significantly compared to that of the untreated control (p <0.001). Simultaneous administration of intratumoral al CEP and intravenous ADR reduced the tumor growth significantly compared to that of ADR alone (p <0.05). Further, CEP restored body weight loss caused by the treatment of ADR (p <0.01). These findings indicate that the combined administration of CEP and ADR may be effective in cancer treatment.
- リンク情報
- ID情報
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- ISSN : 0250-7005
- Web of Science ID : WOS:A1995QW47200011