Feb, 2008
Phase I trial of escalating-dose cisplatin with 5-fluorouracil and concurrent radiotherapy in Chinese patients with esophageal cancer
ACTA MEDICA OKAYAMA
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- Volume
- 62
- Number
- 1
- First page
- 37
- Last page
- 44
- Language
- English
- Publishing type
- DOI
- 10.18926/AMO/30984
- Publisher
- OKAYAMA UNIV MED SCHOOL
We defined the maximum-tolerated dose (MTD) of chemoradiotherapy (cisplatin (CDDP) with 5-fluorouracil (5-FU) and concurrent chemoradiotherapy) for Chinese patients with esophageal cancer. Twenty-one previously untreated patients with primary esophageal cancer were entered into this study. Escalating doses of CDDP with 5-FU were administered in a modified Fibonacci sequence, with concurrent conventional fractionation radiotherapy (CFR) of 60 Gy or 50 Gy. The starting doses were CDDP 37.5 mg/m(2) on day 1, and 5-FU 500 mg/m(2) on days 1-5, respectively. The regimen was repeated 4 times every 28 days. If no dose-limiting toxicity (DLT) was observed, the next dose level was applied. The procedures were repeated until DLT appeared. The MTD was declared to be 1 dose level below the level at which DLT appeared. DLT was grade 3 radiation-induced esophagitis at a dose level of CDDP 60 mg/m(2) with 5-FU 700 mg/m(2) and concurrent 60 Gy CFR. MTD was defined as CDDP 52.5 mg/m(2) with 5-FU 700 mg/m(2) and concurrent 50 Gy CFR. The MTD of CDDP with 5-FU and in concurrent chemoradiotherapy for Chinese patients with esophageal cancer is CDDP 52.5 mg/m(2) on day 1 and 5FU 700 mg/m(2) on days 1-5, repeated 4 times every 28 days, and concurrent 50 Gy CFR. Further evaluation of this regimen in a prospective phase II trial is ongoing.
- Link information
- ID information
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- DOI : 10.18926/AMO/30984
- ISSN : 0386-300X
- Web of Science ID : WOS:000253549500006