Misc.

Oct, 2009

A new phantom using polyethylene glycol as an apparent diffusion coefficient standard for MR imaging

INTERNATIONAL JOURNAL OF ONCOLOGY
  • Ryohei Matsuya
  • Masahiro Kuroda
  • Yoshitsugu Matsumoto
  • Hirokazu Kato
  • Hidenobu Matsuzaki
  • Junichi Asaumi
  • Jun Murakami
  • Kazunori Katashima
  • Masakazu Ashida
  • Takanori Sasaki
  • Tetsuro Sei
  • Kengo Himei
  • Kuniaki Katsui
  • Norihisa Katayama
  • Mitsuhiro Takemoto
  • Susumu Kanazawa
  • Seiichi Mimura
  • Seiichiro Oono
  • Takuichi Kitayama
  • Seiji Tahara
  • Keiji Inamura
  • Display all

Volume
35
Number
4
First page
893
Last page
900
Language
English
Publishing type
DOI
10.3892/ijo_00000404
Publisher
SPANDIDOS PUBL LTD

In recent years, magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has seen wide clinical use, such as for early detection of cerebrovascular diseases and whole body screening for tumors. The apparent diffusion coefficient (ADC) standard phantom, which mimics the ADC values of several lesions in the body, is indispensable for the development of new pulse sequences for DWI, such as diffusion-weighted whole-body imaging with background body-signal suppression (DWIBS). However, information on the ADC values of the previously reported ADC standard phantoms is limited, because these phantoms were made using only a few different materials at a limited range of concentrations, and the ADC values were measured only at certain temperatures. It has been considered difficult, if not impossible, to create a phantom that provides arbitrary ADC values, because it is difficult to calculate the concentrations of the materials and the temperature at ADC measurement. In this study, we used polyethylene glycol (PEG) as a phantom material, and developed an empirical formula to calculate the PEG concentration at any measurement temperature to obtain arbitrary ADC values of the phantom. DWI images of phantoms made using seven different PEG concentrations were taken under heating from 17 to 46 degrees C at 1 degrees C intervals. Using ADC values calculated from these DWI images, we developed two empirical formulas: i) an empirical formula to calculate the ADC values of phantoms made using any PEG concentration at any measurement temperature; and ii) an empirical formula to calculate PEG concentrations to obtain arbitrary ADC values at any measurement temperature. We inspected the accuracy of these empirical formulas by newly made PEG phantoms. A comparison between the ADC values calculated with the empirical formulas and the measured ADC values confirmed the high accuracy of these formulas. PEG phantoms are safe, inexpensive and easy to make, compared with the previously reported ADC standard phantoms. Our empirical formulas enable us to calculate PEG concentrations that provide arbitrary ADC values at any measurement temperature. The empirical formulas could be used within a range of ADC values from 0.37x10(-3) to 3.67x10(-3) mm(2)/s, PEG concentrations from 0 to 120 mM, and measurement temperatures from IS to 45 degrees C. Using these formulas, it would be possible to make standard phantoms that mimic the ADC values of any clinical lesions. The PEG phantom might thus be an excellent new ADC standard phantom for MRI with DWI.

Link information
DOI
https://doi.org/10.3892/ijo_00000404
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000269780600027&DestApp=WOS_CPL
ID information
  • DOI : 10.3892/ijo_00000404
  • ISSN : 1019-6439
  • eISSN : 1791-2423
  • Web of Science ID : WOS:000269780600027

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