Squamous odontogenic tumor (SOT) is a rare lesion apparently of odontogenic origin.<BR>Although 40 cases of this tumor have been reported outside of Japan, only 3 cases have been reported domestically. Only 4 cases of SOT with multilocular radiolucency have been described to our knowledge.<BR>We report a case of maxillary SOT in a 29-year-old woman. Radiography revealed an illdemarcated multilocular radiolucency between the left maxillary lateral incisor and the premolar. The lesion was diagnosed as SOT on examination of a biopsy specimen. Partial maxillectomy was performed. The removed specimen measured 25mm×25mm×20mm. There has been no evidence of recurrence as of 6 years 5 months after the operation.