MISC

2004年1月

Pathological change articular cartilage in of the mandibular head treated with immunosuppressant FK 506

HISTOLOGY AND HISTOPATHOLOGY
  • T Ueno
  • ,
  • T Kagawa
  • ,
  • M Kanou
  • ,
  • T Fujii
  • ,
  • J Fukunaga
  • ,
  • N Mizukawa
  • ,
  • T Sugahara
  • ,
  • T Yamamoto

19
1
開始ページ
15
終了ページ
21
記述言語
英語
掲載種別
出版者・発行元
F HERNANDEZ

While several reports have documented immunosuppressant-induced osteoporosis, the exact mechanism of the pathological change of the joint remains to be clarified. In the present study, we have demonstrated the pathological change of the articular cartilage in the mandibular head of five Sprague-Dawley rats administered with the immunosuppressant FK 506 for 28 days. Three-dimensional micro-computed tomography of the mandibular heads in treated rats showed a significant decrease in trabecular bone volume compared to control rats. Histological observation revealed atrophic change of the articular cartilage. Immunohistological observation using anti-proliferative cell nuclear antibody (PCNA), type I, II, and type X collagen antibodies showed significantly decreased proliferation and differentiation of chondrocytes in the articular cartilage compared with the control group (p<0.05). Tartrate-resistant acid phosphatase (TRAP.) staining revealed no significant difference in the numbers of osteoclasts at the chondro-osseous junction. Thus, FK 506 administration inhibited chondrogenic cell proliferation and differentiation and might cause osteoporotic change of subcartilage trabecular bone that subsequently forms in the mandibular head.

Web of Science ® 被引用回数 : 5

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000188355400003&DestApp=WOS_CPL
ID情報
  • ISSN : 0213-3911
  • Web of Science ID : WOS:000188355400003

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