論文

1999年5月

Role of lentiviral lytic polypeptide I (LLP-I) in the selective cytotoxicity of gamma-glutamylcysteine ethyl ester against human immunodeficiency virus type 1-producing cells

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
  • S Kubota
  • ,
  • H Zhang
  • ,
  • S Kitahara
  • ,
  • RJ Pomerantz

10
3
開始ページ
121
終了ページ
127
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
INT MEDICAL PRESS

Selective cytotoxic effects of gamma-glutamylcysteine ethyl ester (gamma-CCE) against human immunodeficiency virus type 1 (HIV-l)-infected H-9 T lymphocytic cells were demonstrated previously. However, the mechanism of those effects remained unclear. Here, we report on enhanced cytotoxicity of the lentiviral lytic peptide I (LLP-1) of gp41, the envelope transmembrane glycoprotein of HIV-I. in the presence of gamma-GCE. Without gamma-GCE, the cytotoxic effect of LLP-1 was transient, whereas with gamma-GCE, cell death induced by LLP-1 remained continuous until termination. Of note, such effects by gamma-GCE were also observed with another unrelated amphipathic peptide toxin, melittin. These results suggest that the synergistic cytotoxic effect of gamma-GCE and LLP-1 may play a central role in the molecular mechanism of the selective cytotoxicity of gamma-GCE in HIV-l-infected T lymphocytic cells.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000080785300003&DestApp=WOS_CPL
ID情報
  • ISSN : 0956-3202
  • Web of Science ID : WOS:000080785300003

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