1999年5月
Role of lentiviral lytic polypeptide I (LLP-I) in the selective cytotoxicity of gamma-glutamylcysteine ethyl ester against human immunodeficiency virus type 1-producing cells
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
- ,
- ,
- ,
- 巻
- 10
- 号
- 3
- 開始ページ
- 121
- 終了ページ
- 127
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- INT MEDICAL PRESS
Selective cytotoxic effects of gamma-glutamylcysteine ethyl ester (gamma-CCE) against human immunodeficiency virus type 1 (HIV-l)-infected H-9 T lymphocytic cells were demonstrated previously. However, the mechanism of those effects remained unclear. Here, we report on enhanced cytotoxicity of the lentiviral lytic peptide I (LLP-1) of gp41, the envelope transmembrane glycoprotein of HIV-I. in the presence of gamma-GCE. Without gamma-GCE, the cytotoxic effect of LLP-1 was transient, whereas with gamma-GCE, cell death induced by LLP-1 remained continuous until termination. Of note, such effects by gamma-GCE were also observed with another unrelated amphipathic peptide toxin, melittin. These results suggest that the synergistic cytotoxic effect of gamma-GCE and LLP-1 may play a central role in the molecular mechanism of the selective cytotoxicity of gamma-GCE in HIV-l-infected T lymphocytic cells.
- リンク情報
- ID情報
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- ISSN : 0956-3202
- Web of Science ID : WOS:000080785300003