2016年3月1日
ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9
Genes Chromosomes and Cancer
- 巻
- 55
- 号
- 3
- 開始ページ
- 242
- 終了ページ
- 250
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/gcc.22327
© 2015 Wiley Periodicals, Inc. ETV6, which encodes an ETS family transcription factor, is frequently rearranged in human leukemias. We show here that a patient with acute myeloid leukemia with t(7;11)(p15;p15) gained, at the time of relapse, t(11;12)(q12.1;p13) with a split ETV6 FISH signal. Using 3′-RACE PCR analysis, we found that ETV6 was fused to LPXN at 11q12.1, which encodes leupaxin. ETV6-LPXN, an in-frame fusion between exon 4 of ETV6 and exon 2 of LPXN, did not transform the interleukin-3-dependent 32D myeloid cell line to cytokine independence; however, an enhanced proliferative response was observed when these cells were treated with G-CSF without inhibition of granulocytic differentiation. The 32D and human leukemia cell lines each transduced with ETV6-LPXN showed enhanced migration towards the chemokine CXCL12. We show here for the first time that LPXN is a fusion partner of ETV6 and present evidence indicating that ETV6-LPXN plays a crucial role in leukemia progression through enhancing the response to G-CSF and CXCL12.
- リンク情報
- ID情報
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- DOI : 10.1002/gcc.22327
- ISSN : 1045-2257
- eISSN : 1098-2264
- PubMed ID : 26542893
- SCOPUS ID : 84954202602