論文

査読有り
2017年

Low temperature nullifies the circadian clock in cyanobacteria through Hopf bifurcation

Proceedings of the National Academy of Sciences of the United States of America
  • Murayama, Y.
  • ,
  • Kori, H.
  • ,
  • Oshima, C.
  • ,
  • Kondo, T.
  • ,
  • Iwasaki, H.
  • ,
  • Ito, H.

114
22
開始ページ
5641
終了ページ
5646
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.1620378114
出版者・発行元
NATL ACAD SCIENCES

Cold temperatures lead to nullification of circadian rhythms in many organisms. Two typical scenarios explain the disappearance of rhythmicity: the first is oscillation death, which is the transition from self-sustained oscillation to damped oscillation that occurs at a critical temperature. The second scenario is oscillation arrest, in which oscillation terminates at a certain phase. In the field of nonlinear dynamics, these mechanisms are called the Hopf bifurcation and the saddle-node on an invariant circle bifurcation, respectively. Although these mechanisms lead to distinct dynamical properties near the critical temperature, it is unclear to which scenario the circadian clock belongs. Here we reduced the temperature to dampen the reconstituted circadian rhythm of phosphorylation of the recombinant cyanobacterial clock protein KaiC. The data led us to conclude that Hopf bifurcation occurred at similar to 19 degrees C. Below this critical temperature, the self-sustained rhythms of KaiC phosphorylation transformed to damped oscillations, which are predicted by the Hopf bifurcation theory. Moreover, we detected resonant oscillations below the critical temperature when temperature was periodically varied, which was reproduced by numerical simulations. Our findings suggest that the transition to a damped oscillation through Hopf bifurcation contributes to maintaining the circadian rhythm of cyanobacteria through resonance at cold temperatures.

リンク情報
DOI
https://doi.org/10.1073/pnas.1620378114
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28515313
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000402296700045&DestApp=WOS_CPL
Scopus Url
http://www.scopus.com/inward/record.url?eid=2-s2.0-85020014234&partnerID=MN8TOARS
ID情報
  • DOI : 10.1073/pnas.1620378114
  • ISSN : 0027-8424
  • ORCIDのPut Code : 45245372
  • PubMed ID : 28515313
  • SCOPUS ID : 85020014234
  • Web of Science ID : WOS:000402296700045

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