Takahito Nishiyama

Profile Information

Affiliation: Assistant Professor, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Degree: (BLANK)

Researcher number: 80307686
J-GLOBAL ID: 200901049518933563
researchmap Member ID: 1000254596

Research Interests

Research Areas

Research History

Apr, 2021 - Present

Tokyo University of Pharmacy and Life Sciences
Sep, 2007 - Present

Tokyo University of Pharmacy and Life Sciences
Jul, 1998 - Aug, 2007

Tokyo University of Pharmacy and Life Sciences
Apr, 1996 - Jun, 1998

Taiho Pharmaceutical Co., Ltd.

Education

Apr, 1993 - Mar, 1996

Graduate School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Papers

Magnoliae Cortex extract protects PC12 cells from cytotoxicity induced by hydrogen peroxide or 6-hydroxydopamine through enzyme induction

Takahito Nishiyama

6(3) 107-112, Apr, 2019 Peer-reviewedLead author
4-(Hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide has the potential to form 2’-deoxyguanosine and N-acetylcysteine adducts

Takahito Nishiyama, Nahoko Hayashi, Hiromi Yanagita, Tomokazu Ohnuma, Kenichiro Ogura, Akira Hiratsuka

The Journal of Toxicological Sciences, 44(10) 693-699, 2019 Peer-reviewedLead author
Magnolol protects PC12 cells from hydrogen peroxide or 6-hydroxydopamine induced cytotoxicity

Takahito Nishiyama, Yasuhiro Masuda, Tadashi Izawa, Tomokazu Ohnuma, Kenichiro Ogura, Akira Hiratsuka

The Journal of Toxicological Sciences, 44(11) 753-758, 2019 Peer-reviewedLead author
Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells

Tomokazu Ohnuma, Kazuya Sakamoto, Asumi Shinoda, Chiaki Takagi, Shoko Ohno, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 635 66-73, Dec, 2017 Peer-reviewed
Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract

Tomokazu Ohnuma, Eri Anzai, Yohei Suzuki, Mai Shimoda, Shin Saito, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 585 17-24, Nov, 2015 Peer-reviewed
Formation and stability of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in mice

Takahito Nishiyama, Nahoko Hayashi, Naoki Kakurai, Hiromi Yanagita, Ai Kuriyama, Chika Miyamoto, Yumi Ishihara, Kenichiro Ogura, Tomokazu Ohnuma, Akira Hiratsuka

JOURNAL OF TOXICOLOGICAL SCIENCES, 39(4) 515-521, Aug, 2014 Peer-reviewedLead author
Tissue distributions of 4-(hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide, a stable form of reactive intermediate produced from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in the rat

Takahito Nishiyama, Kenichiro Ogura, Tomokazu Ohnuma, Akira Hiratsuka

JOURNAL OF TOXICOLOGICAL SCIENCES, 39(2) 263-267, Apr, 2014 Peer-reviewedLead author
Involvement of Different Human Glutathione Transferase Isoforms in the Glutathione Conjugation of Reactive Metabolites of Troglitazone

Ran Okada, Kazuya Maeda, Takahito Nishiyama, Shinsuke Aoyama, Zenzaburo Tozuka, Akira Hiratsuka, Toshihiko Ikeda, Hiroyuki Kusuhara, Yuichi Sugiyama

DRUG METABOLISM AND DISPOSITION, 39(12) 2290-2297, Dec, 2011 Peer-reviewed
Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract

Tomokazu Ohnuma, Takashi Matsumoto, Ayano Itoi, Ayako Kawana, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 413(4) 623-629, Oct, 2011 Peer-reviewed
Dietary Diacetylene Falcarindiol Induces Phase 2 Drug-Metabolizing Enzymes and Blocks Carbon Tetrachloride-Induced Hepatotoxicity in Mice through Suppression of Lipid Peroxidation

Tomokazu Ohnuma, Eisaburo Anan, Rika Hoashi, Yuika Takeda, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 34(3) 371-378, Mar, 2011 Peer-reviewed
STABLE ISOTOPE DILUTION MASS SPECTROMETRIC ASSAY FOR PRPP USING ENZYMATIC PROCEDURES

Y. Shinohara, Y. Suzuki, H. Hasegawa, M. Nakamura, T. Nishiyama, A. Hiratsuka, K. Ichida

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 30(12) 1140-1146, 2011 Peer-reviewed
Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound

Tomokazu Ohnuma, Shinji Nakayama, Eisaburo Anan, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

TOXICOLOGY AND APPLIED PHARMACOLOGY, 244(1) 27-36, Apr, 2010 Peer-reviewed
Cooperation of NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferases reduces menadione cytotoxicity in HEK293 cells

Takahito Nishiyama, Tadashi Izawa, Mami Usami, Tomokazu Ohnuma, Kenichiro Ogura, Akira Hiratsuka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 394(3) 459-463, Apr, 2010 Peer-reviewedLead author
Role of phase 2 drug-metabolizing enzymes modulated by extracts from 78 herbal medicines in detoxification of electrophiles and lung cancer chemotherapy

Tomokazu Ohnuma, Takashi Matsumoto, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka, Takao Komatsu, Hiroshi Iwata

Journal of Traditional Medicines, 27(3) 122-133, 2010 Peer-reviewed
Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress

Tomokazu Ohnuma, Takao Komatsu, Shinji Nakayama, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 488(1) 34-41, Aug, 2009 Peer-reviewed
Amino acid positions 69-132 of UGT1A9 are involved in the C-glucuronidation of phenylbutazone

Takahito Nishiyama, Miki Fujishima, Yasuhiro Masuda, Tadashi Izawa, Tomokazu Ohnuma, Kenichiro Ogura, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 478(1) 75-80, Oct, 2008 Peer-reviewedLead author
UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation

Takahito Nishiyama, Tornokazu Ohnuma, Yuu Inoue, Takehiko Kishi, Kenichiro Ogura, Akira Hiratsuka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 371(2) 247-250, Jun, 2008 Peer-reviewedLead author
Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells

Keiko Taguchi, Megumi Shimada, Sayako Fujii, Daigo Sumi, Xiaoqing Pan, Shigeru Yamano, Takahito Nishiyama, Akira Hiratsuka, Masayuki Yamamoto, Arthur K. Cho …

FREE RADICAL BIOLOGY AND MEDICINE, 44(8) 1645-1655, Apr, 2008 Peer-reviewed
Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone

Takahito Nishiyama, Tomihiro Kobori, Kouji Arai, Kenichiro Ogura, Tomokazu Ohnuma, Kazuo Ishii, Kenichiro Hayashi, Akira Hiratsuka

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 454(1) 72-79, Oct, 2006 Peer-reviewedLead author
Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4

K Ogura, Y Ishikawa, T Kaku, T Nishiyama, T Ohnuma, K Muro, A Hiratsuka

BIOCHEMICAL PHARMACOLOGY, 71(9) 1358-1369, Apr, 2006 Peer-reviewed

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Research Projects

タンパク質相互作用が関与する多価不飽和脂肪酸ヒドロペルオキシドの消去機構

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2003 - 2004

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