論文

査読有り
2004年12月

Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies

BLOOD
  • S Takahashi
  • T Iseki
  • J Ooi
  • A Tomonari
  • K Takasugi
  • Y Shimohakamada
  • T Yamada
  • K Uchimaru
  • A Tojo
  • N Shirafuji
  • H Kodo
  • K Tani
  • T Takahashi
  • T Yamaguchi
  • S Asano
  • 全て表示

104
12
開始ページ
3813
終了ページ
3820
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1182/blood-2004-03-1001
出版者・発行元
AMER SOC HEMATOLOGY

Unrelated cord blood transplantation (CBT) has now become more common, but as yet there have been only a few reports on its outcome compared with bone marrow transplantation (BMT), especially for adults. We studied the clinical outcomes of 113 adult patients with hematologic malignancies who received unrelated BM transplants (n = 45) or unrelated CB transplants (n = 68). We analyzed the hematopoietic recovery, rates of graft-versus-host disease (GVHD), risks of trans plantation-related mortality (TRM) and relapse, and disease-free survival (DFS) using Cox proportional hazards models. The time from donor search to transplantation was significantly shorter among CB transplant recipients (median, 2 months) than BM transplant recipients (median, 11 months; P < .01). Multivariate analysis demonstrated slow neutrophil (P < .01) and platelet (P < .01) recoveries in CBT patients compared with BMT patients. Despite rapid tapering of immunosuppressants after transplantation and infrequent use of steroids to treat severe acute GVHD, there were no GVHD-related deaths among CB transplant recipients compared with 10 deaths of 24 among BM transplant recipients. Unrelated CBT showed better TRM and DFS results compared with BMT (P = .02 and P < .01, respectively), despite the higher human leukocyte antigen mismatching rate and lower number of infused cells. These data strongly suggest that CBT could be safely and effectively used for adult patients with hematologic malignancies.

リンク情報
DOI
https://doi.org/10.1182/blood-2004-03-1001
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15280199
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000225351600064&DestApp=WOS_CPL
ID情報
  • DOI : 10.1182/blood-2004-03-1001
  • ISSN : 0006-4971
  • PubMed ID : 15280199
  • Web of Science ID : WOS:000225351600064

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