論文

査読有り 最終著者 責任著者
2007年3月

Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon

FEBS LETTERS
  • Akemi Hoshino
  • ,
  • Hodaka Fujii

581
5
開始ページ
975
終了ページ
980
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.febslet.2007.01.083
出版者・発行元
ELSEVIER SCIENCE BV

Cytokines control cell differentiation, proliferation, and function by regulating gene expression program. Physiological roles and induction mechanisms of cytokine-inducible genes are not fully understood. Here, we identified a novel immediate-early cytokine-responsive gene, cyclon (atokine-induced protein with coiled-coil domain), which is induced in a hematopoietic cell line by interleukin 3 (IL-3). cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino-terminus and a coiled-coil domain in the carboxyl-terminus. A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL-3-induced gene expression. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.febslet.2007.01.083
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000244941100031&DestApp=WOS_CPL
URL
http://orcid.org/0000-0003-1296-4256
ID情報
  • DOI : 10.1016/j.febslet.2007.01.083
  • ISSN : 0014-5793
  • ORCIDのPut Code : 12277115
  • Web of Science ID : WOS:000244941100031

エクスポート
BibTeX RIS