2007年3月
Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon
FEBS LETTERS
- ,
- 巻
- 581
- 号
- 5
- 開始ページ
- 975
- 終了ページ
- 980
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.febslet.2007.01.083
- 出版者・発行元
- ELSEVIER SCIENCE BV
Cytokines control cell differentiation, proliferation, and function by regulating gene expression program. Physiological roles and induction mechanisms of cytokine-inducible genes are not fully understood. Here, we identified a novel immediate-early cytokine-responsive gene, cyclon (atokine-induced protein with coiled-coil domain), which is induced in a hematopoietic cell line by interleukin 3 (IL-3). cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino-terminus and a coiled-coil domain in the carboxyl-terminus. A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL-3-induced gene expression. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.febslet.2007.01.083
- ISSN : 0014-5793
- ORCIDのPut Code : 12277115
- Web of Science ID : WOS:000244941100031