1998年3月
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
GENES & DEVELOPMENT
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- 巻
- 12
- 号
- 6
- 開始ページ
- 770
- 終了ページ
- 775
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- COLD SPRING HARBOR LAB PRESS
Many cytokines transmit signals to the cell interior through activation of receptor-associated, Janus family protein tyrosine kinases (Jak PTKs). The interleukin-2 receptor (IL-2R) is associated with the Jak1 and Jak3 PTKs, and ligand-induced activation of these PTKs is essential for lymphocyte proliferation. Here, the nonreceptor PTK, Pyk2, was found to be activated following IL-2 stimulation in a Jak-dependent manner. Furthermore, physical association was detected between endogenous Pyk2 and Jak3, and a dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a newly identified component of the Jak-mediated IL-2 signaling pathway.
- リンク情報
- ID情報
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- ISSN : 0890-9369
- ORCIDのPut Code : 12277126
- Web of Science ID : WOS:000072770300002